Reference No. R Position Title: Computational Scientist (Machine Learning) - Protein Language Models & Antibody-Antigen Interaction Department: Data Strategy Program Management Location: Cambridge, MA About Sanofi: We are an innovative global healthcare company, driven by one purpose: chasing the miracles of science to improve people's lives. Our team, across some 100 countries, is dedicated to transforming the practice of medicine by working to turn the impossible into the possible. We provide potentially life-changing treatment options and life-saving vaccine protection to millions of people globally, while putting sustainability and social responsibility at the center of our ambitions. Sanofi has recently embarked on a vast and ambitious digital transformation program. A cornerstone of this roadmap is the acceleration of its data transformation and of the adoption of artificial intelligence (AI) and machine learning (ML) solutions to accelerate R&D, manufacturing and commercial performance, and bring better drugs and vaccines to patients faster, to improve health and save lives. In alignment to our digital transformation, we have launched a new major strategic initiative in 2023: the Biologics x AI Transformation. This is positioned to be a unique data-driven team, with expertise in AI platforms, data engineering, ML operations, data science, computational biology, strategy, and beyond. We are working as one to identify, design, and scale state-of-the-art AI capabilities targeted to truly transform how we research biologics. Who You Are: You are a dynamic Computational Scientist who will work with other scientists to apply cutting-edge computation, Machine Learning/Deep Learning approaches to revolutionize our large molecule computational tools by contributing to accelerating and improving the process of design and engineering of novel biologics drug candidates. Job Highlights: Apply and develop artificial intelligence and machine learning (AI/ML) approaches (e.g. classification, clustering, machine learning, deep learning) on pharma research data sets (e.g. activity, function, ADME properties, physico-chemical properties, etc.) Building models from internal and external data sources, algorithms, simulations, and performance evaluation by writing code and using state-of-the art machine learning technologies. Close interactions with other Computational scientists, data engineers, software engineers, UX designers, as well as research scientists in core scientific platforms focusing on protein therapeutics, in an international context (US, Europe, China) Update and report relevant results to interdisciplinary project teams and stakeholders Maintain a keen awareness of recent developments in data science and bioinformatics and state-of-the-art of AI/ML/DL algorithms and research results Active engagement in evaluation and coordination of both academic and startup collaborations as well as outsourcing partners. Key Functional Requirements & Qualifications: Advanced degree (PhD) in a field related to AI/ML or Data Analytics such as: Computer Science, Mathematics, Statistics, Physics, Biophysics, Computational Biology or Engineering Sciences. Experience with a track record of applying ML/Deep Learning (DL) approaches to solve molecule-related problems. Strong familiarity with protein structure or sequence featurization/embeddings. Strong familiarity with advanced statistics, ML/DL techniques including various network architectures (CNNs, GANs, RNNs, Auto-Encoders, Transformers, PLM etc.), regularization, embeddings, loss-functions, optimization strategies, or reinforcement learning techniques. Proficiency in Python and deep learning libraries such as PyTorch, TensorFlow, Keras, Scikit-learn, Numpy, Matpilotlib. Strong familiarity with data visualization and dimensionality reduction algorithms Ability to develop, benchmark and apply predictive algorithms to generate hypotheses Comfortable working in cloud and high-performance computational environments (e.g. AWS) Excellent written and verbal communication, strong tropism for teamwork Strong understanding of pharma R&D process is a plus. A change agent with a combination of business, science & technology, and diplomatic skills At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all. Sanofi is committed to welcoming and integrating people with disabilities. Only those candidates selected for interviews will be contacted. Sanofi is an equal opportunity employer committed to diversity and inclusion. Our goal is to attract, develop and retain highly talented employees from diverse backgrounds, allowing us to benefit from a wide variety of experiences and perspectives. We welcome and encourage applications from all qualified applicants. Accommodations for persons with disabilities required during the recruitment process are available upon request. Thank you in advance for your interest. As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. This position will require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. Pursue Progress Discover Extraordinary Better is out there. Better medications, better outcomes, better science. But progress doesn't happen without people - people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let's be those people. Pursue progress , discover extraordinary Better is out there. Better medications, better outcomes, better science. But progress doesn't happen without people - people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let's be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at !
04/25/2024
Full time
Reference No. R Position Title: Computational Scientist (Machine Learning) - Protein Language Models & Antibody-Antigen Interaction Department: Data Strategy Program Management Location: Cambridge, MA About Sanofi: We are an innovative global healthcare company, driven by one purpose: chasing the miracles of science to improve people's lives. Our team, across some 100 countries, is dedicated to transforming the practice of medicine by working to turn the impossible into the possible. We provide potentially life-changing treatment options and life-saving vaccine protection to millions of people globally, while putting sustainability and social responsibility at the center of our ambitions. Sanofi has recently embarked on a vast and ambitious digital transformation program. A cornerstone of this roadmap is the acceleration of its data transformation and of the adoption of artificial intelligence (AI) and machine learning (ML) solutions to accelerate R&D, manufacturing and commercial performance, and bring better drugs and vaccines to patients faster, to improve health and save lives. In alignment to our digital transformation, we have launched a new major strategic initiative in 2023: the Biologics x AI Transformation. This is positioned to be a unique data-driven team, with expertise in AI platforms, data engineering, ML operations, data science, computational biology, strategy, and beyond. We are working as one to identify, design, and scale state-of-the-art AI capabilities targeted to truly transform how we research biologics. Who You Are: You are a dynamic Computational Scientist who will work with other scientists to apply cutting-edge computation, Machine Learning/Deep Learning approaches to revolutionize our large molecule computational tools by contributing to accelerating and improving the process of design and engineering of novel biologics drug candidates. Job Highlights: Apply and develop artificial intelligence and machine learning (AI/ML) approaches (e.g. classification, clustering, machine learning, deep learning) on pharma research data sets (e.g. activity, function, ADME properties, physico-chemical properties, etc.) Building models from internal and external data sources, algorithms, simulations, and performance evaluation by writing code and using state-of-the art machine learning technologies. Close interactions with other Computational scientists, data engineers, software engineers, UX designers, as well as research scientists in core scientific platforms focusing on protein therapeutics, in an international context (US, Europe, China) Update and report relevant results to interdisciplinary project teams and stakeholders Maintain a keen awareness of recent developments in data science and bioinformatics and state-of-the-art of AI/ML/DL algorithms and research results Active engagement in evaluation and coordination of both academic and startup collaborations as well as outsourcing partners. Key Functional Requirements & Qualifications: Advanced degree (PhD) in a field related to AI/ML or Data Analytics such as: Computer Science, Mathematics, Statistics, Physics, Biophysics, Computational Biology or Engineering Sciences. Experience with a track record of applying ML/Deep Learning (DL) approaches to solve molecule-related problems. Strong familiarity with protein structure or sequence featurization/embeddings. Strong familiarity with advanced statistics, ML/DL techniques including various network architectures (CNNs, GANs, RNNs, Auto-Encoders, Transformers, PLM etc.), regularization, embeddings, loss-functions, optimization strategies, or reinforcement learning techniques. Proficiency in Python and deep learning libraries such as PyTorch, TensorFlow, Keras, Scikit-learn, Numpy, Matpilotlib. Strong familiarity with data visualization and dimensionality reduction algorithms Ability to develop, benchmark and apply predictive algorithms to generate hypotheses Comfortable working in cloud and high-performance computational environments (e.g. AWS) Excellent written and verbal communication, strong tropism for teamwork Strong understanding of pharma R&D process is a plus. A change agent with a combination of business, science & technology, and diplomatic skills At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all. Sanofi is committed to welcoming and integrating people with disabilities. Only those candidates selected for interviews will be contacted. Sanofi is an equal opportunity employer committed to diversity and inclusion. Our goal is to attract, develop and retain highly talented employees from diverse backgrounds, allowing us to benefit from a wide variety of experiences and perspectives. We welcome and encourage applications from all qualified applicants. Accommodations for persons with disabilities required during the recruitment process are available upon request. Thank you in advance for your interest. As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. This position will require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. Pursue Progress Discover Extraordinary Better is out there. Better medications, better outcomes, better science. But progress doesn't happen without people - people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let's be those people. Pursue progress , discover extraordinary Better is out there. Better medications, better outcomes, better science. But progress doesn't happen without people - people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let's be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at !
Pay Range: $45 to $51 Per Hour Job Description: Job Title: Assistant/Associate Scientist Location: Seattle, WA ONSITE TOP SKILLS - The candidate must have demonstrated verbal, written, and communication skills including ability to present complex information clearly and concisely, with a successful proven history of working with technical teams. - Experience should include management of lab activities, technical support of a cGMP manufacturing facility, including strong knowledge and engineering leadership for viral vector manufacturing and processing equipment, and process characterization. - Prefer experience with leading experiments and designing DOEs - Prior experience in/knowledge of cell culture, viral vector manufacturing, recovery and/or purification of viral vector product in a manufacturing environment preferred POSITION SUMMARY: The Assistant/Associate Scientist/Engineer to join our Vector and Gene Delivery MS&T group in GDPAD . The successful candidate will design and execute experiments related to supporting commercial vector manufacturing processes. This person will collaborate across all CMC functional areas to insure project advancement, rapid and best in class execution, and communication of challenges/opportunities. Duties/Responsibilities: - Oversee lab activities and schedule - Design studies to support commercial manufacturing deviation investigations. - Support the the execution of process characterization studies. - Collaborate with commercial vector team to identify opportunities for process improvements, make formal recommendations. - Lead identification and implementation of new technologies and procedures from Development into Manufacturing - Lead efforts focusing on alignment and harmonization of manufacturing process across multiple sites - Support the hands-on training of commercial process unit operations to Vector MS&T - Identify, design and manage small capital engineering projects
04/24/2024
Full time
Pay Range: $45 to $51 Per Hour Job Description: Job Title: Assistant/Associate Scientist Location: Seattle, WA ONSITE TOP SKILLS - The candidate must have demonstrated verbal, written, and communication skills including ability to present complex information clearly and concisely, with a successful proven history of working with technical teams. - Experience should include management of lab activities, technical support of a cGMP manufacturing facility, including strong knowledge and engineering leadership for viral vector manufacturing and processing equipment, and process characterization. - Prefer experience with leading experiments and designing DOEs - Prior experience in/knowledge of cell culture, viral vector manufacturing, recovery and/or purification of viral vector product in a manufacturing environment preferred POSITION SUMMARY: The Assistant/Associate Scientist/Engineer to join our Vector and Gene Delivery MS&T group in GDPAD . The successful candidate will design and execute experiments related to supporting commercial vector manufacturing processes. This person will collaborate across all CMC functional areas to insure project advancement, rapid and best in class execution, and communication of challenges/opportunities. Duties/Responsibilities: - Oversee lab activities and schedule - Design studies to support commercial manufacturing deviation investigations. - Support the the execution of process characterization studies. - Collaborate with commercial vector team to identify opportunities for process improvements, make formal recommendations. - Lead identification and implementation of new technologies and procedures from Development into Manufacturing - Lead efforts focusing on alignment and harmonization of manufacturing process across multiple sites - Support the hands-on training of commercial process unit operations to Vector MS&T - Identify, design and manage small capital engineering projects
Overview Weatherford is a leading global energy services company. Our world-class experts partner with customers to optimize their resources and realize the full potential of their assets. Across our operating locations, including manufacturing, research and development, service, and training facilities, operators choose us for strategic solutions that add efficiency, flexibility, and responsibility to any energy operation. We are focused on technology development, digital solutions, and defining our footprint in the new energy space. Our ability to provide integrated solutions across our segments will be critical to growth in our core operations and the energy transition. Energy producers face unique challenges every day, so it is our job to create solutions that enhance safety, streamline operations, and sustain uptime to meet or exceed their targets. We operate across the global energy landscape employing some of the best diverse talent in the industry. At Weatherford, we understand the value each individual brings to the table. We celebrate diversity in all its forms and are immensely proud of our workforce. We invite you to join our passionate, talented, word-class team. When you join Weatherford, you instantly feel connected to something bigger - a community that is grounded by our core values and driven to create innovative solutions for our customers. We celebrate each other's successes, grow together, and learn from each other constantly. Individually, we are impressive. Together, we are unstoppable. We are One Weatherford. Weatherford offers competitive compensation, a comprehensive benefits program and provides you a challenging and enriching career path, with a healthy balance of structure and flexibility to chart your own course. Weatherford is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, religion, national or ethnic origin, sex, sexual orientation, gender identity or expression, age, disability, protected veteran status or other characteristics protected by law . Responsibilities Weatherford is hiring a Technical Writer for our Spencer Road Research & Devolopment facility in Houston, TX. Job Purpose The Wireline Technical Writer is responsible for leading the effort to maintain the existing manufacturing, field facing and client facing documentation specific to the Wireline (WL) Products and Wireline Services activities. The Tech Writer is the internal subject matter expert (SME) for utilizing the principles of Simplified Technical English (STE) in order to ensure that documents created or updated are suitable for English as a Second Language (ESL) readers or for translation. The Tech Writer is the interface between the engineering and scientific staff that creates the original content, modification content and the outside world. Roles & Responsibilities DOCUMENT CREATION & MAINTENANCE Receives original content from RD&E technicians, engineers & scientists, and places the content in proper formatting into existing templates. Tech Writer is responsible for language simplification and clarity without altering technical aspects of the content. Sits with RD&E technicians, engineers & scientists to capture original content directly during hands-on process & procedures, converting that information into first drafts of technical content for review by RD&E SMEs. Modifies documentation in Windchill as changes are requested by RD&E SMEs, Operations, Manufacturing or external clients. Leads the effort to get documents completed in a timely fashion, which means managing the workflow between the various staff and stakeholders required to finalize content. Perform annual audits on technical documentation to ensure that the items in repositories outside Windchill are in sync with Windchill, and correct any discrepancies. Maintains documentation in Windchill (WFRD PDM system) SAFETY, SECURITY & COMPLIANCE Maintains the highest standards of corporate governance, ensuring that all activities are carried out ethically and in compliance with Company's Security, Compliance & HSE policies, Management System, relevant laws, regulations, standards and industry practices and complies with the Company's Rules to Live By Places Quality, Health & Safety, Security and protection of the Environment as core values while never intentionally placing employees, our processes, customers or the communities in which we live and work at risk Seeks continual improvement in Health, Safety, Security & protection of the Environment, taking into account responsible care, process vulnerabilities, public, customer and employee inputs, knowledge and technology and best business practices to exceed customer expectations QUALITY Responsible for being familar with the Company's Quality policies and takes an active role in the compliance and improvement of Weatherford's Management System Maintains service quality as immediate priorities when working across all areas of the business and continually seeks areas for improvement Demonstrated ability to lead in process and guidelines improvement OPERATIONS Works with the Wireline (WL) Products Team to create the field operations and repair & maintenance manuals needed to support the business. Works with the WL Products customer support staff to update documents, improve readability, make corrections, etc. Works with the WL Services WISE Team to update documents as requested by field operations. Works with the WISE and RDE Teams to create missing documents needed to support operations. Serve as an SME for general writing and Word support to field staff creating document markups or creating original content. Keep current with WISE Queries which they monitor to provide timely feedback for operations on document related tasking. COMMUNICATION Maintains effective communications with all key stakeholders both internal and, where appropriate, external Can communicate with others effectively in speaking and in writing. Uses vocabulary required to successfully express thoughts, ideas and explanations. Demonstrated ability to clearly present ideas to an audience of colleagues and audience outside of product line. FINANCIAL All employees have an accountability to the organisation to be financially responsible whether they are in charge of a function budget or simply their own expenses Costs incurred should be within approved budget, processed within agreed time frames & following the relevant financial policy and procedure PEOPLE & DEVELOPMENT Employees have a responsibility for developing their own careers within the Company including completing all necessary function, compliance & business standards training to enhance their knowledge, skills and experience Employees should engage on a regular basis with their line manager to discuss their personal performance, objectives and opportunities to enhance their skills and experience to support their career potential Is committed to continuous personal development and sharing knowledge VISION & LEADERSHIP Demontrates leadership, ethical behaviour and adherence to Weatherford standards at all times Provides mentoring and training to others Builds reciprocal relationship with team members and shares experiences, new ideas, and learnings with team members Has regular interactions with cross functional members of the project team (product owners, stakeholders, SMEs, and when necessary clients/customers) Leads and contributes to technical reviews and works well with a team of peers Drives improvements by adopting emerging technologies where possible Qualifications Experience & Education REQUIRED Bachelor's degree in English or communication related field 2 - 5 years experience technical writing PREFERRED 2 - 5 years experience technical writing in oil and gas industry Knowledge, Skills & Abilities REQUIRED Strong command of English language and grammar Excellent communication skills, both oral and written Ability to work independently or in groups Ability to capture data at bench with RDE staff Knowledge of engineering or engineering technology Knowledge of Standard Technical English (STE) Advanced skills in Microsoft Office Suite and Adobe Acrobat Template creation Organized and detail-oriented Experience working with ArborText Editor Desktop publishing Knowledge of various types of documentation (Procedures, Work Instructions, Test Sheets, etc.) Editing and formatting skills Ability to work well with all levels of personnel. PREFERRED Proficient working with FrameMaker Proficient in the use of STE (Simplified Technical English) Experience working with Windchill Advanced skills with ArborText Editor (template creation, profiling, etc.) Travel Requirement: This role may require domestic and potentially international travel: <10%
04/24/2024
Full time
Overview Weatherford is a leading global energy services company. Our world-class experts partner with customers to optimize their resources and realize the full potential of their assets. Across our operating locations, including manufacturing, research and development, service, and training facilities, operators choose us for strategic solutions that add efficiency, flexibility, and responsibility to any energy operation. We are focused on technology development, digital solutions, and defining our footprint in the new energy space. Our ability to provide integrated solutions across our segments will be critical to growth in our core operations and the energy transition. Energy producers face unique challenges every day, so it is our job to create solutions that enhance safety, streamline operations, and sustain uptime to meet or exceed their targets. We operate across the global energy landscape employing some of the best diverse talent in the industry. At Weatherford, we understand the value each individual brings to the table. We celebrate diversity in all its forms and are immensely proud of our workforce. We invite you to join our passionate, talented, word-class team. When you join Weatherford, you instantly feel connected to something bigger - a community that is grounded by our core values and driven to create innovative solutions for our customers. We celebrate each other's successes, grow together, and learn from each other constantly. Individually, we are impressive. Together, we are unstoppable. We are One Weatherford. Weatherford offers competitive compensation, a comprehensive benefits program and provides you a challenging and enriching career path, with a healthy balance of structure and flexibility to chart your own course. Weatherford is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, religion, national or ethnic origin, sex, sexual orientation, gender identity or expression, age, disability, protected veteran status or other characteristics protected by law . Responsibilities Weatherford is hiring a Technical Writer for our Spencer Road Research & Devolopment facility in Houston, TX. Job Purpose The Wireline Technical Writer is responsible for leading the effort to maintain the existing manufacturing, field facing and client facing documentation specific to the Wireline (WL) Products and Wireline Services activities. The Tech Writer is the internal subject matter expert (SME) for utilizing the principles of Simplified Technical English (STE) in order to ensure that documents created or updated are suitable for English as a Second Language (ESL) readers or for translation. The Tech Writer is the interface between the engineering and scientific staff that creates the original content, modification content and the outside world. Roles & Responsibilities DOCUMENT CREATION & MAINTENANCE Receives original content from RD&E technicians, engineers & scientists, and places the content in proper formatting into existing templates. Tech Writer is responsible for language simplification and clarity without altering technical aspects of the content. Sits with RD&E technicians, engineers & scientists to capture original content directly during hands-on process & procedures, converting that information into first drafts of technical content for review by RD&E SMEs. Modifies documentation in Windchill as changes are requested by RD&E SMEs, Operations, Manufacturing or external clients. Leads the effort to get documents completed in a timely fashion, which means managing the workflow between the various staff and stakeholders required to finalize content. Perform annual audits on technical documentation to ensure that the items in repositories outside Windchill are in sync with Windchill, and correct any discrepancies. Maintains documentation in Windchill (WFRD PDM system) SAFETY, SECURITY & COMPLIANCE Maintains the highest standards of corporate governance, ensuring that all activities are carried out ethically and in compliance with Company's Security, Compliance & HSE policies, Management System, relevant laws, regulations, standards and industry practices and complies with the Company's Rules to Live By Places Quality, Health & Safety, Security and protection of the Environment as core values while never intentionally placing employees, our processes, customers or the communities in which we live and work at risk Seeks continual improvement in Health, Safety, Security & protection of the Environment, taking into account responsible care, process vulnerabilities, public, customer and employee inputs, knowledge and technology and best business practices to exceed customer expectations QUALITY Responsible for being familar with the Company's Quality policies and takes an active role in the compliance and improvement of Weatherford's Management System Maintains service quality as immediate priorities when working across all areas of the business and continually seeks areas for improvement Demonstrated ability to lead in process and guidelines improvement OPERATIONS Works with the Wireline (WL) Products Team to create the field operations and repair & maintenance manuals needed to support the business. Works with the WL Products customer support staff to update documents, improve readability, make corrections, etc. Works with the WL Services WISE Team to update documents as requested by field operations. Works with the WISE and RDE Teams to create missing documents needed to support operations. Serve as an SME for general writing and Word support to field staff creating document markups or creating original content. Keep current with WISE Queries which they monitor to provide timely feedback for operations on document related tasking. COMMUNICATION Maintains effective communications with all key stakeholders both internal and, where appropriate, external Can communicate with others effectively in speaking and in writing. Uses vocabulary required to successfully express thoughts, ideas and explanations. Demonstrated ability to clearly present ideas to an audience of colleagues and audience outside of product line. FINANCIAL All employees have an accountability to the organisation to be financially responsible whether they are in charge of a function budget or simply their own expenses Costs incurred should be within approved budget, processed within agreed time frames & following the relevant financial policy and procedure PEOPLE & DEVELOPMENT Employees have a responsibility for developing their own careers within the Company including completing all necessary function, compliance & business standards training to enhance their knowledge, skills and experience Employees should engage on a regular basis with their line manager to discuss their personal performance, objectives and opportunities to enhance their skills and experience to support their career potential Is committed to continuous personal development and sharing knowledge VISION & LEADERSHIP Demontrates leadership, ethical behaviour and adherence to Weatherford standards at all times Provides mentoring and training to others Builds reciprocal relationship with team members and shares experiences, new ideas, and learnings with team members Has regular interactions with cross functional members of the project team (product owners, stakeholders, SMEs, and when necessary clients/customers) Leads and contributes to technical reviews and works well with a team of peers Drives improvements by adopting emerging technologies where possible Qualifications Experience & Education REQUIRED Bachelor's degree in English or communication related field 2 - 5 years experience technical writing PREFERRED 2 - 5 years experience technical writing in oil and gas industry Knowledge, Skills & Abilities REQUIRED Strong command of English language and grammar Excellent communication skills, both oral and written Ability to work independently or in groups Ability to capture data at bench with RDE staff Knowledge of engineering or engineering technology Knowledge of Standard Technical English (STE) Advanced skills in Microsoft Office Suite and Adobe Acrobat Template creation Organized and detail-oriented Experience working with ArborText Editor Desktop publishing Knowledge of various types of documentation (Procedures, Work Instructions, Test Sheets, etc.) Editing and formatting skills Ability to work well with all levels of personnel. PREFERRED Proficient working with FrameMaker Proficient in the use of STE (Simplified Technical English) Experience working with Windchill Advanced skills with ArborText Editor (template creation, profiling, etc.) Travel Requirement: This role may require domestic and potentially international travel: <10%
Pay Ranges: $45 $54 Job Description: - PhD with 2+ years of industry experience in molecular assay development, or MS/MA in Molecular Biology or similar with 5+ years of related experience, or BS/BA with 10+ years of related experience. - Design, develop, and qualify molecular-based analytical methods, including multiplex PCR-based assays using qPCR , RT-qPCR , ddPCR , to support pipeline cell therapies. - Experience designing and executing experiments to demonstrate assay comparability and to determine assay performance, including the assessment of specificity, accuracy, precision, linearity, and robustness. - Prepare complex technical documents, including SOPs, test methods, study protocols, and reports. Position Summary Cell Therapy is one of the most groundbreaking new forms of cancer treatments being studied today. With therapies only in their infancy and Client's continued investment in our Cell Therapy capabilities, the growth potential of this science, your career, and the ability to help patients are incredible. The Molecular Assay Development team is seeking an accomplished (Senior) Scientist to join our team within the Cellular Therapy Analytical Development (CTAD) organization. The (Senior) Scientist will act as a mentor and leader within a team of scientists who are collectively responsible for molecular biology-based QC and characterization methods supporting autologous and allogeneic cell therapies. These methods will be used to further the understanding of cell therapies, support development of the manufacturing processes, and QC release of the drug product. This position is responsible for the technology platform screening, development, qualification, and transfer of molecular biology-based analytical methods; as well as the life-cycle management of these methods. The (Senior) Scientist will have extensive hands-on experience in assay development; possess excellent communication skills; and be able to work with cross-functional teams in order to effectively transfer analytical methods, as wells as maintain and troubleshoot existing methods.
04/21/2024
Full time
Pay Ranges: $45 $54 Job Description: - PhD with 2+ years of industry experience in molecular assay development, or MS/MA in Molecular Biology or similar with 5+ years of related experience, or BS/BA with 10+ years of related experience. - Design, develop, and qualify molecular-based analytical methods, including multiplex PCR-based assays using qPCR , RT-qPCR , ddPCR , to support pipeline cell therapies. - Experience designing and executing experiments to demonstrate assay comparability and to determine assay performance, including the assessment of specificity, accuracy, precision, linearity, and robustness. - Prepare complex technical documents, including SOPs, test methods, study protocols, and reports. Position Summary Cell Therapy is one of the most groundbreaking new forms of cancer treatments being studied today. With therapies only in their infancy and Client's continued investment in our Cell Therapy capabilities, the growth potential of this science, your career, and the ability to help patients are incredible. The Molecular Assay Development team is seeking an accomplished (Senior) Scientist to join our team within the Cellular Therapy Analytical Development (CTAD) organization. The (Senior) Scientist will act as a mentor and leader within a team of scientists who are collectively responsible for molecular biology-based QC and characterization methods supporting autologous and allogeneic cell therapies. These methods will be used to further the understanding of cell therapies, support development of the manufacturing processes, and QC release of the drug product. This position is responsible for the technology platform screening, development, qualification, and transfer of molecular biology-based analytical methods; as well as the life-cycle management of these methods. The (Senior) Scientist will have extensive hands-on experience in assay development; possess excellent communication skills; and be able to work with cross-functional teams in order to effectively transfer analytical methods, as wells as maintain and troubleshoot existing methods.
Director of Non-Clinical San Francisco, CA Company Overview: Our client is a cutting-edge biotech startup revolutionizing the field of genetic medicine with our proprietary Lipid Nanoparticle (LNP) technology. Our patented delivery mechanism offers superior efficacy and safety compared to traditional RNA or DNA delivery methods. Founded by a visionary PhD graduate from Stanford University, we are driven by a passion for innovation and a commitment to transforming healthcare through advanced biotechnology. Position Overview: Were seeking a highly skilled and motivated Director of Non-Clinical to lead our preclinical research efforts. The successful candidate will be pivotal in advancing our LNP platform through rigorous experimentation and data-driven decision-making. This individual will build a talented team of scientists and researchers, design the strategy, research plan, and operation plan, set up the lab, and design the experiments, in close collaboration with other functional areas to drive the development of novel therapeutics. Key Responsibilities: Lead and manage the Non-Clinical team to design, plan, and execute preclinical studies evaluating the efficacy, safety, and pharmacokinetics of LNP-based therapeutics. Develop and implement comprehensive research strategies to optimize LNP formulations and delivery systems, leveraging a deep understanding of lipid nanoparticle technology and its applications. Establish and maintain strong relationships with external partners, including contract research organizations (CROs) and academic collaborators, to support preclinical studies and ensure timely project execution, including technology transfer and QC. Drive the generation of high-quality scientific data to support regulatory submissions, including IND filing, and advance product development milestones. Collaborate cross-functionally with colleagues in research, clinical development, regulatory affairs, and manufacturing to integrate non-clinical findings into overall product development strategies. Stay abreast of the latest advancements in lipid nanoparticle technology, RNA/DNA therapeutics, and relevant scientific literature to inform decision-making and maintain a competitive edge. Contribute to scientific publications, presentations, and patent applications to communicate research findings and protect intellectual property. Foster a culture of scientific excellence, innovation, and collaboration within the Non-Clinical team and across the organization. Additional Information: Experience with filing Investigational New Drug (IND) applications and navigating regulatory processes for drug development, including interactions with regulatory agencies such as the FDA. Familiarity with protein engineering techniques and their applications in therapeutic development, particularly in the context of lipid nanoparticle-based delivery systems. Leadership role in overseeing non-clinical activities post-IND, including toxicology studies, pharmacology assessments, and IND-enabling studies. Onsite presence required in San Francisco, facilitating collaboration and communication with cross-functional teams. Lead researcher responsible for coordinating activities with contract research organizations (CROs), including technology transfer, quality control (QC), and oversight of studies conducted externally. Direct involvement in the design and development of experiments and protocols sent to CROs, ensuring alignment with project goals and objectives. Experience working with laboratory facilities such as Bakar and NBC, leveraging their expertise and resources for research and development activities. We Offer Competitive salary in the range of $200,000 to $250,000, commensurate with experience and qualifications. Opportunity for a 20% performance-based bonus, reflecting the company's commitment to rewarding exceptional contributions. Equity participation in the range of 3-5%, providing a stake in the company's success and alignment with long-term growth objectives. Join us and be part of a dynamic team driving innovation at the intersection of biotechnology and medicine. Together, we are pioneering new treatments and improving the lives of patients worldwide. Apply now to make a difference!
04/21/2024
Director of Non-Clinical San Francisco, CA Company Overview: Our client is a cutting-edge biotech startup revolutionizing the field of genetic medicine with our proprietary Lipid Nanoparticle (LNP) technology. Our patented delivery mechanism offers superior efficacy and safety compared to traditional RNA or DNA delivery methods. Founded by a visionary PhD graduate from Stanford University, we are driven by a passion for innovation and a commitment to transforming healthcare through advanced biotechnology. Position Overview: Were seeking a highly skilled and motivated Director of Non-Clinical to lead our preclinical research efforts. The successful candidate will be pivotal in advancing our LNP platform through rigorous experimentation and data-driven decision-making. This individual will build a talented team of scientists and researchers, design the strategy, research plan, and operation plan, set up the lab, and design the experiments, in close collaboration with other functional areas to drive the development of novel therapeutics. Key Responsibilities: Lead and manage the Non-Clinical team to design, plan, and execute preclinical studies evaluating the efficacy, safety, and pharmacokinetics of LNP-based therapeutics. Develop and implement comprehensive research strategies to optimize LNP formulations and delivery systems, leveraging a deep understanding of lipid nanoparticle technology and its applications. Establish and maintain strong relationships with external partners, including contract research organizations (CROs) and academic collaborators, to support preclinical studies and ensure timely project execution, including technology transfer and QC. Drive the generation of high-quality scientific data to support regulatory submissions, including IND filing, and advance product development milestones. Collaborate cross-functionally with colleagues in research, clinical development, regulatory affairs, and manufacturing to integrate non-clinical findings into overall product development strategies. Stay abreast of the latest advancements in lipid nanoparticle technology, RNA/DNA therapeutics, and relevant scientific literature to inform decision-making and maintain a competitive edge. Contribute to scientific publications, presentations, and patent applications to communicate research findings and protect intellectual property. Foster a culture of scientific excellence, innovation, and collaboration within the Non-Clinical team and across the organization. Additional Information: Experience with filing Investigational New Drug (IND) applications and navigating regulatory processes for drug development, including interactions with regulatory agencies such as the FDA. Familiarity with protein engineering techniques and their applications in therapeutic development, particularly in the context of lipid nanoparticle-based delivery systems. Leadership role in overseeing non-clinical activities post-IND, including toxicology studies, pharmacology assessments, and IND-enabling studies. Onsite presence required in San Francisco, facilitating collaboration and communication with cross-functional teams. Lead researcher responsible for coordinating activities with contract research organizations (CROs), including technology transfer, quality control (QC), and oversight of studies conducted externally. Direct involvement in the design and development of experiments and protocols sent to CROs, ensuring alignment with project goals and objectives. Experience working with laboratory facilities such as Bakar and NBC, leveraging their expertise and resources for research and development activities. We Offer Competitive salary in the range of $200,000 to $250,000, commensurate with experience and qualifications. Opportunity for a 20% performance-based bonus, reflecting the company's commitment to rewarding exceptional contributions. Equity participation in the range of 3-5%, providing a stake in the company's success and alignment with long-term growth objectives. Join us and be part of a dynamic team driving innovation at the intersection of biotechnology and medicine. Together, we are pioneering new treatments and improving the lives of patients worldwide. Apply now to make a difference!
Mission The Data Scientist is responsible for conducting undirected research and tackle open-ended data problems and questions. Drawing on an advanced degree in a quantitative field such as computer science, physics, statistics or applied mathematics, the Data Scientist demonstrates the knowledge to invent new algorithms to solve data problems. Responsibilities Research and assess next-generation technologies for machinery diagnostics and prognostics and data-driven modeling and optimization of complex systems. Demonstrate advanced working knowledge and experience with machine learning algorithms and population-based meta-heuristic optimization methods. Generate innovative ideas, establish new research directions, and shape and execute on technical projects. Maintain state-of-the-art knowledge and contribute to technical discussions and reviews as an expert in related areas of responsibility. Apply theoretical knowledge to solve industrial problems. Apply engineering knowledge in developing data-driven algorithms for anomaly detection, failure prediction and optimization. Collaborate with field and product engineers to identify key health monitoring parameters of a system. Process large multivariate data sets collected from equipment operations, manufacturing tests and diagnostic routines. Communicate ideas, plans and results effectively via oral and written reports. Experience & Exposures: Data Science and Analytics Algorithmic Development PhD PhD
04/18/2024
Full time
Mission The Data Scientist is responsible for conducting undirected research and tackle open-ended data problems and questions. Drawing on an advanced degree in a quantitative field such as computer science, physics, statistics or applied mathematics, the Data Scientist demonstrates the knowledge to invent new algorithms to solve data problems. Responsibilities Research and assess next-generation technologies for machinery diagnostics and prognostics and data-driven modeling and optimization of complex systems. Demonstrate advanced working knowledge and experience with machine learning algorithms and population-based meta-heuristic optimization methods. Generate innovative ideas, establish new research directions, and shape and execute on technical projects. Maintain state-of-the-art knowledge and contribute to technical discussions and reviews as an expert in related areas of responsibility. Apply theoretical knowledge to solve industrial problems. Apply engineering knowledge in developing data-driven algorithms for anomaly detection, failure prediction and optimization. Collaborate with field and product engineers to identify key health monitoring parameters of a system. Process large multivariate data sets collected from equipment operations, manufacturing tests and diagnostic routines. Communicate ideas, plans and results effectively via oral and written reports. Experience & Exposures: Data Science and Analytics Algorithmic Development PhD PhD
My client, a fast-paced research and technology development start-up, is currently seeking an Ion Exchange Chemical Engineer or Chemist to join their Seattle, Washington team. My client aims to radically reduce the cost of carbon capture, hasten the transition to a net zero carbon economy, and slow the effects of global warming. To meet this challenge, they are developing a process to extract CO2 from seawater using light-activated chemicals that is projected to require a fraction of the energy inputs compared to competing carbon capture methods. They are transitioning from prototypes in the lab towards a larger scale pilot and first-of-kind commercial facility. They have secured a carbon removal pre-purchase contract with Frontier, closed an oversubscribed financing round, and are supported by a stellar team of investors. Summary: My client is seeking a highly motivated and creative chemist or chemical engineer to help develop and optimize their carbon capture process. The individual must be passionate about applying fundamental chemical and engineering principles to develop scalable industrial processes. The focus of this position will be developing and evaluating methods for transferring ions between solutions in the absence of applied electric fields. Candidates may have a background in separation processes, analytical chemistry, and/or process engineering. The ideal candidate will have extensive experience in the theory, testing, prototyping, and scaling of ion exchange processes, for example using ion exchange resins. The successful candidate will work collaboratively with a small team of scientists and engineers to advance our carbon capture technology from concept to deployment. Position Type: This is an in-person regular full-time position located in Seattle, WA. Desired Start Date: As soon as possible. Location: Located within CoMotion Labs on the beautiful campus of the University of Washington. This setting unites the fast paced and exciting environment of a startup with the thriving intellectual community and advanced instrumentation of a major research university. A light rail station, recreational sports facilities, the Burke-Gilman bike trail, and the Lake Washington Waterfront are all within a half mile of the company's office and lab space. A transit pass with unlimited rides and membership at the university's recreational sports facility are included in current company benefits. This is an in-person position located in Seattle, WA. Seattle is a thriving and dynamic city situated between the snowcapped Cascade Mountains and the waters of Puget Sound. Benefits: My client is proud to offer employees a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Current benefits include: 401(k) with 6% employer match Stock options Medical, vision, and dental coverage through a QSEHRA health benefits plan 15 days of paid time off per year in addition to paid sick time 13 additional paid holidays annually, including 11 federal and state holidays and 2 floating holidays to recognize cultural, religious, or personally significant events. Relocation assistance (negotiable) Transit pass that includes unlimited light rail and bus trips Holistic employee assistance program Recreational sports facility membership reimbursement Duties/Responsibilities: â Use theory and modeling approaches to conceptualize, develop, and optimize ion exchange and chemical processes. â Design, prototype, and scale processes to efficiently transfer ions between aqueous solutions at an industrial scale. â Evaluate designs with respect to energy efficiency, manufacturability, longevity, and financial metrics (OPEX and CAPEX). â Identify risks and introduce innovative strategies that can overcome these risks to effectively enhance process performance. â Clearly document the design, evaluation, and development process in written laboratory books and electronic documents following best engineering practices. â Conduct work with a commitment to the highest levels of safety and integrity. This includes understanding and adhering to EH&S standards, policies, and procedures, to promote safe work habits. â Contribute to regular updates of the company's technoeconomic assessment. â Provide technical insight and effectively communicate and collaborate with a team of scientists and engineers to advance our carbon capture technology. â Review technical bids, contribute to purchasing decisions, carry out technical checks of performance data for major equipment and contribute to subsequent assembly and troubleshooting. â Collaborate with business staff to support technical business development, develop supply chain relationships, and to refine process components to best fit market needs. â Ensure that projects are completed on time. â Mentor and manage technical staff for performance and professional growth. â Find, apply, and communicate relevant advances from technical and scientific literature. â Perform other related duties as required. Experience & Qualifications: â PhD or MS in Chemical Engineering, Chemistry, Environmental Engineering, or related field with relevant post-degree work experience. BS degrees will be considered with extensive work experience. â Ideal candidates will have industry experience in water treatment, oil and gas, chemical manufacturing and processing, or related fields. â Extensive wet chemistry lab experience. â Ideal candidates will have experience with industrial-scale ion exchange proceses. â Excellent verbal and written communication skills. â Familiar with statistical data analysis and design of experiment methodologies. â Strong sense of project ownership with hands-on and can-do attitude. â Creative self-starter that is interested in solving problems without a pre-defined answer. â Excellent understanding of lab and field safety and ethical research processes. â Strong communication skills - able to disseminate information at internal and external technical forums. â Good interpersonal skills, including working with cross-functional teams. â Current authorization to work in the US and ability to relocate to the Seattle, WA USA area is required. Travel: • 10-20% travel may be required Physical Requirements: â Will sit, stand, or walk short distances for up to the entire duration of a shift. â Will climb stairs on an occasional basis. â Will lift, push, or pull up to 27 pounds on an occasional basis. â Required to use hands to grasp, lift, handle, carry or feel objects on a frequent basis. â Must be able to comply with all safety standards and procedures. â Ability to work at a computer for extended periods of time, which includes typing, viewing data, and manipulating documents and data. â May reach above shoulder heights and below the waist on a frequent basis. â May stoop, kneel, or bend, on an occasional basis. â Ability to wear personal protective equipment is required (including (including but not limited to: nitrile gloves, lab coat, safety glasses, hearing protection, hard hat, safety footwear). With over 90 years' combined experience, NES Fircroft (NES) is proud to be the world's leading engineering staffing provider spanning the Oil & Gas, Power & Renewables, Chemicals, Construction & Infrastructure, Life Sciences, Mining and Manufacturing sectors worldwide. With more than 80 offices in 45 countries, we are able to provide our clients with the engineering and technical expertise they need, wherever and whenever it is needed. We offer contractors far more than a traditional recruitment service, supporting with everything from securing visas and work permits, to providing market-leading benefits packages and accommodation, ensuring they are safely and compliantly able to support our clients.
04/17/2024
Full time
My client, a fast-paced research and technology development start-up, is currently seeking an Ion Exchange Chemical Engineer or Chemist to join their Seattle, Washington team. My client aims to radically reduce the cost of carbon capture, hasten the transition to a net zero carbon economy, and slow the effects of global warming. To meet this challenge, they are developing a process to extract CO2 from seawater using light-activated chemicals that is projected to require a fraction of the energy inputs compared to competing carbon capture methods. They are transitioning from prototypes in the lab towards a larger scale pilot and first-of-kind commercial facility. They have secured a carbon removal pre-purchase contract with Frontier, closed an oversubscribed financing round, and are supported by a stellar team of investors. Summary: My client is seeking a highly motivated and creative chemist or chemical engineer to help develop and optimize their carbon capture process. The individual must be passionate about applying fundamental chemical and engineering principles to develop scalable industrial processes. The focus of this position will be developing and evaluating methods for transferring ions between solutions in the absence of applied electric fields. Candidates may have a background in separation processes, analytical chemistry, and/or process engineering. The ideal candidate will have extensive experience in the theory, testing, prototyping, and scaling of ion exchange processes, for example using ion exchange resins. The successful candidate will work collaboratively with a small team of scientists and engineers to advance our carbon capture technology from concept to deployment. Position Type: This is an in-person regular full-time position located in Seattle, WA. Desired Start Date: As soon as possible. Location: Located within CoMotion Labs on the beautiful campus of the University of Washington. This setting unites the fast paced and exciting environment of a startup with the thriving intellectual community and advanced instrumentation of a major research university. A light rail station, recreational sports facilities, the Burke-Gilman bike trail, and the Lake Washington Waterfront are all within a half mile of the company's office and lab space. A transit pass with unlimited rides and membership at the university's recreational sports facility are included in current company benefits. This is an in-person position located in Seattle, WA. Seattle is a thriving and dynamic city situated between the snowcapped Cascade Mountains and the waters of Puget Sound. Benefits: My client is proud to offer employees a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Current benefits include: 401(k) with 6% employer match Stock options Medical, vision, and dental coverage through a QSEHRA health benefits plan 15 days of paid time off per year in addition to paid sick time 13 additional paid holidays annually, including 11 federal and state holidays and 2 floating holidays to recognize cultural, religious, or personally significant events. Relocation assistance (negotiable) Transit pass that includes unlimited light rail and bus trips Holistic employee assistance program Recreational sports facility membership reimbursement Duties/Responsibilities: â Use theory and modeling approaches to conceptualize, develop, and optimize ion exchange and chemical processes. â Design, prototype, and scale processes to efficiently transfer ions between aqueous solutions at an industrial scale. â Evaluate designs with respect to energy efficiency, manufacturability, longevity, and financial metrics (OPEX and CAPEX). â Identify risks and introduce innovative strategies that can overcome these risks to effectively enhance process performance. â Clearly document the design, evaluation, and development process in written laboratory books and electronic documents following best engineering practices. â Conduct work with a commitment to the highest levels of safety and integrity. This includes understanding and adhering to EH&S standards, policies, and procedures, to promote safe work habits. â Contribute to regular updates of the company's technoeconomic assessment. â Provide technical insight and effectively communicate and collaborate with a team of scientists and engineers to advance our carbon capture technology. â Review technical bids, contribute to purchasing decisions, carry out technical checks of performance data for major equipment and contribute to subsequent assembly and troubleshooting. â Collaborate with business staff to support technical business development, develop supply chain relationships, and to refine process components to best fit market needs. â Ensure that projects are completed on time. â Mentor and manage technical staff for performance and professional growth. â Find, apply, and communicate relevant advances from technical and scientific literature. â Perform other related duties as required. Experience & Qualifications: â PhD or MS in Chemical Engineering, Chemistry, Environmental Engineering, or related field with relevant post-degree work experience. BS degrees will be considered with extensive work experience. â Ideal candidates will have industry experience in water treatment, oil and gas, chemical manufacturing and processing, or related fields. â Extensive wet chemistry lab experience. â Ideal candidates will have experience with industrial-scale ion exchange proceses. â Excellent verbal and written communication skills. â Familiar with statistical data analysis and design of experiment methodologies. â Strong sense of project ownership with hands-on and can-do attitude. â Creative self-starter that is interested in solving problems without a pre-defined answer. â Excellent understanding of lab and field safety and ethical research processes. â Strong communication skills - able to disseminate information at internal and external technical forums. â Good interpersonal skills, including working with cross-functional teams. â Current authorization to work in the US and ability to relocate to the Seattle, WA USA area is required. Travel: • 10-20% travel may be required Physical Requirements: â Will sit, stand, or walk short distances for up to the entire duration of a shift. â Will climb stairs on an occasional basis. â Will lift, push, or pull up to 27 pounds on an occasional basis. â Required to use hands to grasp, lift, handle, carry or feel objects on a frequent basis. â Must be able to comply with all safety standards and procedures. â Ability to work at a computer for extended periods of time, which includes typing, viewing data, and manipulating documents and data. â May reach above shoulder heights and below the waist on a frequent basis. â May stoop, kneel, or bend, on an occasional basis. â Ability to wear personal protective equipment is required (including (including but not limited to: nitrile gloves, lab coat, safety glasses, hearing protection, hard hat, safety footwear). With over 90 years' combined experience, NES Fircroft (NES) is proud to be the world's leading engineering staffing provider spanning the Oil & Gas, Power & Renewables, Chemicals, Construction & Infrastructure, Life Sciences, Mining and Manufacturing sectors worldwide. With more than 80 offices in 45 countries, we are able to provide our clients with the engineering and technical expertise they need, wherever and whenever it is needed. We offer contractors far more than a traditional recruitment service, supporting with everything from securing visas and work permits, to providing market-leading benefits packages and accommodation, ensuring they are safely and compliantly able to support our clients.
Job Description Avery Dennison is seeking an energetic Polymer Scientist who is able to deploy deep expertise in rheology to address product performance and novel concepts in adhesion, release (pressure sensitive laminates of soft polymers and films) and coating and polymer processing related challenges. The position will be with the Materials Science and Characterization (MSC) Group, which primarily supports Global R&D activities at Avery Dennison's Mentor, OH location, chartered to support and resolve technical problems from long term projects to urgent manufacturing and quality issues stemming from across Avery Dennison's global operations. The position will involve the use of deep experimental, theoretical and modeling based understanding of viscoelasticity of polymer melts, solution and soft matter. Astute problem solving using structure-process-property principles leveraging materials chemistry, adhesion science, modeling and surface/interface/rheological physics with a high focus on practical applications. RESPONSIBILITIES: Drive fundamental understanding and insights of complex materials and time/rate dependent phenomena (polymeric adhesives, block copolymers, nanostructured hybrid materials, gels, colloids and multi-layer laminates) using a full spectrum of rheological and allied approaches. Develop material structure-process-property-performance correlations. Use strong materials fundamentals (polymer physics) to champion novel design paradigms in areas of interest to AD. Provide technical leadership by developing highly practical programs to achieve project objectives including working in cross-functional teams. Interact with teams composed of experimental synthetic scientists, characterization, predictive modeling, product developers and process technologists to develop the insights from physical models, theory and surgical experiments that enable rapid exploration of design parameter space without need for extensive prototyping. Distill concepts to a highly fundamental level using scaling and modeling treating problems unified by similar physical/chemical processes as a class, leading to the development of new material concepts. Develop and implement test methods to support new product/process development projects and discern structure-property relationships. Conceive and render efficient testing of materials and material discovery using high throughput methods. Interface with SMEs in rheology/spectroscopy/ physical testing, computing & analytical/process/product development teams etc. to help surface relevant structure-property relationships and guide experiments and technical approach to obtain data for model parameterization and validation. Interpret data, write technical reports, and communicate research activities and results with other divisional scientists in a high-quality, professional, and timely manner. Be the subject matter expert in rheology and fluid mechanics. Establish and utilize rheological signatures to determine polymer structure and models thereof. Work to provide timely support working in close collaboration with immediate and extended team members (Chemists, Engineers, end users) and cross-functional teams situated globally (US, Europe, Asia & South America). Proactively initiate and execute upon relevant R&D projects and platforms. Conceive and execute experimental investigations including validation on pilot and production scale as necessary Develop and implement test methods including custom built setup to support new product/process development projects and discern structure-property relationships. Utilize theoretical and modeling approaches (rheological, mesoscale and AI/ML based) to deliver deep insights and identify scaling relationships and their application in driving significant breakthrough solutions. Constantly seek to bring in new characterization techniques and depth in understanding of the underlying Material Science in areas of interest. Interpret data, write technical reports, and communicate analytical results with MSC and divisional scientists and production engineers in a high-quality, professional, and timely manner. Provide and maintain a safe work environment by participating in safety programs, committees, or teams and by conducting laboratory and pilot plant safety audits.
04/16/2024
Full time
Job Description Avery Dennison is seeking an energetic Polymer Scientist who is able to deploy deep expertise in rheology to address product performance and novel concepts in adhesion, release (pressure sensitive laminates of soft polymers and films) and coating and polymer processing related challenges. The position will be with the Materials Science and Characterization (MSC) Group, which primarily supports Global R&D activities at Avery Dennison's Mentor, OH location, chartered to support and resolve technical problems from long term projects to urgent manufacturing and quality issues stemming from across Avery Dennison's global operations. The position will involve the use of deep experimental, theoretical and modeling based understanding of viscoelasticity of polymer melts, solution and soft matter. Astute problem solving using structure-process-property principles leveraging materials chemistry, adhesion science, modeling and surface/interface/rheological physics with a high focus on practical applications. RESPONSIBILITIES: Drive fundamental understanding and insights of complex materials and time/rate dependent phenomena (polymeric adhesives, block copolymers, nanostructured hybrid materials, gels, colloids and multi-layer laminates) using a full spectrum of rheological and allied approaches. Develop material structure-process-property-performance correlations. Use strong materials fundamentals (polymer physics) to champion novel design paradigms in areas of interest to AD. Provide technical leadership by developing highly practical programs to achieve project objectives including working in cross-functional teams. Interact with teams composed of experimental synthetic scientists, characterization, predictive modeling, product developers and process technologists to develop the insights from physical models, theory and surgical experiments that enable rapid exploration of design parameter space without need for extensive prototyping. Distill concepts to a highly fundamental level using scaling and modeling treating problems unified by similar physical/chemical processes as a class, leading to the development of new material concepts. Develop and implement test methods to support new product/process development projects and discern structure-property relationships. Conceive and render efficient testing of materials and material discovery using high throughput methods. Interface with SMEs in rheology/spectroscopy/ physical testing, computing & analytical/process/product development teams etc. to help surface relevant structure-property relationships and guide experiments and technical approach to obtain data for model parameterization and validation. Interpret data, write technical reports, and communicate research activities and results with other divisional scientists in a high-quality, professional, and timely manner. Be the subject matter expert in rheology and fluid mechanics. Establish and utilize rheological signatures to determine polymer structure and models thereof. Work to provide timely support working in close collaboration with immediate and extended team members (Chemists, Engineers, end users) and cross-functional teams situated globally (US, Europe, Asia & South America). Proactively initiate and execute upon relevant R&D projects and platforms. Conceive and execute experimental investigations including validation on pilot and production scale as necessary Develop and implement test methods including custom built setup to support new product/process development projects and discern structure-property relationships. Utilize theoretical and modeling approaches (rheological, mesoscale and AI/ML based) to deliver deep insights and identify scaling relationships and their application in driving significant breakthrough solutions. Constantly seek to bring in new characterization techniques and depth in understanding of the underlying Material Science in areas of interest. Interpret data, write technical reports, and communicate analytical results with MSC and divisional scientists and production engineers in a high-quality, professional, and timely manner. Provide and maintain a safe work environment by participating in safety programs, committees, or teams and by conducting laboratory and pilot plant safety audits.
Date Posted: 04/12/2024 Hiring Organization: Rose International Position Number: 462231 Job Title: Fermentation Technician Job Location: Chesterfield, MO, USA, 63017 Work Model: Onsite Shift: M-F start time 8:00am 40 hours a week Employment Type: Temporary Estimated Duration (In months): 13 Min Hourly Rate ($): 35.00 Max Hourly Rate ($): 44.00 Must Have Skills/Attributes: Biology, Laboratory, Science Job Description Only those lawfully authorized to work in the designated country associated with the position will be considered. Please note that all Position start dates, and duration are estimates and may be reduced or lengthened based upon a client's business needs and requirements. We are looking for a talented Fermentation Technician to support our fermentation processes and contribute to the success of our projects. In this role, you will be responsible for assisting in the execution of fermentation experiments, monitoring and maintaining fermentation equipment, analyzing data, and ensuring compliance with safety and quality standards. The Fermentation Technician will play a vital role in optimizing fermentation processes and contributing to the development of innovative products. EDUCATION REQUIREMENT(S) • Bachelor's degree in microbiology, chemical engineering, bioprocessing or related scientific field. REQUIREMENTS • Experience making solutions, making media and plates, cleaning labware, operating autoclaves and industrial dishwashers, placing orders as needed • Able to prioritize and execute simultaneous tasks • Comfortable working within a small, collaborative team • Experience with following lab safety protocols and procedures • 5 plus years' experience PREFERENCES • Experience with fermentation equipment. • Experience with sterile technique and microbiology. • Experience working with yeast and bacterial organisms is a plus. • Familiarity with spreadsheet software and dealing with large data sets. POSITION DUTIES & RESPONSIBILITIES • Participate in the preparation and execution of fermentations up to 300L • Participate in activities directly related to different aspects of process development and industrialization of bioprocesses • You will contribute to the development of critical process development for the manufacturing of biologics • Supporting the research scientists, routine analysis, reporting and communicating results • Conduct pilot scale fermentation trials, routine experiments, organizing and communicating results; may provide routine analysis as needed • Make solutions, media, and plates • Prepare and stage materials to support experiments • Clean and sterilize labware • Assemble and disassemble glass fermentation vessels • Place orders and monitor inventory • Coordinate workload with the Fermentation Engineering team and other Lab Assistants • Help maintain an orderly lab Benefits: For information and details on employment benefits offered with this position, please visit here. Should you have any questions/concerns, please contact our HR Department via our secure website. California Pay Equity: For information and details on pay equity laws in California, please visit the State of California Department of Industrial Relations' website here.
04/15/2024
Full time
Date Posted: 04/12/2024 Hiring Organization: Rose International Position Number: 462231 Job Title: Fermentation Technician Job Location: Chesterfield, MO, USA, 63017 Work Model: Onsite Shift: M-F start time 8:00am 40 hours a week Employment Type: Temporary Estimated Duration (In months): 13 Min Hourly Rate ($): 35.00 Max Hourly Rate ($): 44.00 Must Have Skills/Attributes: Biology, Laboratory, Science Job Description Only those lawfully authorized to work in the designated country associated with the position will be considered. Please note that all Position start dates, and duration are estimates and may be reduced or lengthened based upon a client's business needs and requirements. We are looking for a talented Fermentation Technician to support our fermentation processes and contribute to the success of our projects. In this role, you will be responsible for assisting in the execution of fermentation experiments, monitoring and maintaining fermentation equipment, analyzing data, and ensuring compliance with safety and quality standards. The Fermentation Technician will play a vital role in optimizing fermentation processes and contributing to the development of innovative products. EDUCATION REQUIREMENT(S) • Bachelor's degree in microbiology, chemical engineering, bioprocessing or related scientific field. REQUIREMENTS • Experience making solutions, making media and plates, cleaning labware, operating autoclaves and industrial dishwashers, placing orders as needed • Able to prioritize and execute simultaneous tasks • Comfortable working within a small, collaborative team • Experience with following lab safety protocols and procedures • 5 plus years' experience PREFERENCES • Experience with fermentation equipment. • Experience with sterile technique and microbiology. • Experience working with yeast and bacterial organisms is a plus. • Familiarity with spreadsheet software and dealing with large data sets. POSITION DUTIES & RESPONSIBILITIES • Participate in the preparation and execution of fermentations up to 300L • Participate in activities directly related to different aspects of process development and industrialization of bioprocesses • You will contribute to the development of critical process development for the manufacturing of biologics • Supporting the research scientists, routine analysis, reporting and communicating results • Conduct pilot scale fermentation trials, routine experiments, organizing and communicating results; may provide routine analysis as needed • Make solutions, media, and plates • Prepare and stage materials to support experiments • Clean and sterilize labware • Assemble and disassemble glass fermentation vessels • Place orders and monitor inventory • Coordinate workload with the Fermentation Engineering team and other Lab Assistants • Help maintain an orderly lab Benefits: For information and details on employment benefits offered with this position, please visit here. Should you have any questions/concerns, please contact our HR Department via our secure website. California Pay Equity: For information and details on pay equity laws in California, please visit the State of California Department of Industrial Relations' website here.
Job Description Seeking a driven individual to be part of our Advanced Sensors Engineering Team to apply their Atomic Layer Deposition (ALD) expertise and experience to develop new processes and approaches which improve on designs. The incumbent troubleshoots development problems with the fabrication process and takes corrective action with designing process integration for multi-wafer integration to ensure quality, manufacturability and costs are met. Applies advanced principles, concepts, techniques and theories gained through extensive study and experience. Performs unusually complex tasks and develops highly innovative solutions. Plans and implements learning cycles on specific aspects of projects. Works closely with management and/or customers on technical issues, risk resolution and associated schedules. Compiles and presents data to management and/or customers during product development and through production manufacturing transition. The candidate should have a background in applied physics, materials science, electrical engineering, chemistry, or similar field and have demonstrated examples of self-driven efforts in technical areas outside of their academic training. The candidate will work in a diverse team-based environment alongside technical staff of varying levels of expertise and should be able to execute technical tasks and communicate technical matters to engineering and management. The ability to work independently and be flexible to the continuously-evolving nature of research and development efforts is essential. The in-person position includes significant on-site and in-lab contributions. Primary Duties/Responsibilities: Design, Lead, Execute and Report experiments, write up data sets and process flows Produce prototypes to flesh out new processes and document the process for verification Able to design and establish process of record for the following (R&D and Support for Manufacturing Engineering)Preparation, handling and fixturing of substrates for atomic layer deposition Precursor selection and recipe development for optimized uniformity, stoichiometry and film performance Film characterization techniques and process monitoring including ellipsometry, SEM, XPS, etc. Experience or familiarity with the following Tools/Processes: Atomic Layer Deposition, Ultra-High Vacuum Systems, common MEMS / semiconductor processes and general cleanroom environments Read and understand process documents attached to the company's products.
04/15/2024
Full time
Job Description Seeking a driven individual to be part of our Advanced Sensors Engineering Team to apply their Atomic Layer Deposition (ALD) expertise and experience to develop new processes and approaches which improve on designs. The incumbent troubleshoots development problems with the fabrication process and takes corrective action with designing process integration for multi-wafer integration to ensure quality, manufacturability and costs are met. Applies advanced principles, concepts, techniques and theories gained through extensive study and experience. Performs unusually complex tasks and develops highly innovative solutions. Plans and implements learning cycles on specific aspects of projects. Works closely with management and/or customers on technical issues, risk resolution and associated schedules. Compiles and presents data to management and/or customers during product development and through production manufacturing transition. The candidate should have a background in applied physics, materials science, electrical engineering, chemistry, or similar field and have demonstrated examples of self-driven efforts in technical areas outside of their academic training. The candidate will work in a diverse team-based environment alongside technical staff of varying levels of expertise and should be able to execute technical tasks and communicate technical matters to engineering and management. The ability to work independently and be flexible to the continuously-evolving nature of research and development efforts is essential. The in-person position includes significant on-site and in-lab contributions. Primary Duties/Responsibilities: Design, Lead, Execute and Report experiments, write up data sets and process flows Produce prototypes to flesh out new processes and document the process for verification Able to design and establish process of record for the following (R&D and Support for Manufacturing Engineering)Preparation, handling and fixturing of substrates for atomic layer deposition Precursor selection and recipe development for optimized uniformity, stoichiometry and film performance Film characterization techniques and process monitoring including ellipsometry, SEM, XPS, etc. Experience or familiarity with the following Tools/Processes: Atomic Layer Deposition, Ultra-High Vacuum Systems, common MEMS / semiconductor processes and general cleanroom environments Read and understand process documents attached to the company's products.
Job Description We are looking for a highly motivated person who can drive the development of antibody-drug conjugate drug substances, from FIH programs to late-stage development. The candidate will lead a group of scientists in the development of conjugation chemistry as well as downstream unit operations culminating in drug substance and may have supervisory responsibilities. The candidate will serve as the chemistry representative on the CMC team for ADC development programs and as such would be responsible for developing timelines and executing activities required for drug substance. The candidate must be able to mentor and develop staff with novel experimental approaches to answer difficult scientific questions. Working with analytical and manufacturing colleagues, the candidate will develop productive collaborations and communications with scientific teams. Responsibilities: The candidate will lead activities associated with process development and characterization for new ADC drug substances. Lead the design and execution of process development and control strategies. Lead process chemistry development for FIH programs. Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management. Mentor staff in troubleshooting strategic and experimental issues. Author and review key regulatory documents, laboratory data, technical memos and reports. Collaborate to ensure successful CMC interactions with regulatory authorities. The position involves multi-disciplinary interactions with other chemists, analytical chemists, engineers, drug product development, and program management. The selected candidate will collaborate with Asset Development Teams to advance clinical candidates. It is expected that the candidate will utilize his/her expertise across CMC disciplines to further program goals via collaborations with drug product development, regulatory affairs, and commercial operations. The candidate will encourage ideas for continuous improvement activities and initiatives within work group. The candidate will understand and adhere to corporate standards regarding code of conduct, safety and GXP compliance.
04/09/2024
Full time
Job Description We are looking for a highly motivated person who can drive the development of antibody-drug conjugate drug substances, from FIH programs to late-stage development. The candidate will lead a group of scientists in the development of conjugation chemistry as well as downstream unit operations culminating in drug substance and may have supervisory responsibilities. The candidate will serve as the chemistry representative on the CMC team for ADC development programs and as such would be responsible for developing timelines and executing activities required for drug substance. The candidate must be able to mentor and develop staff with novel experimental approaches to answer difficult scientific questions. Working with analytical and manufacturing colleagues, the candidate will develop productive collaborations and communications with scientific teams. Responsibilities: The candidate will lead activities associated with process development and characterization for new ADC drug substances. Lead the design and execution of process development and control strategies. Lead process chemistry development for FIH programs. Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management. Mentor staff in troubleshooting strategic and experimental issues. Author and review key regulatory documents, laboratory data, technical memos and reports. Collaborate to ensure successful CMC interactions with regulatory authorities. The position involves multi-disciplinary interactions with other chemists, analytical chemists, engineers, drug product development, and program management. The selected candidate will collaborate with Asset Development Teams to advance clinical candidates. It is expected that the candidate will utilize his/her expertise across CMC disciplines to further program goals via collaborations with drug product development, regulatory affairs, and commercial operations. The candidate will encourage ideas for continuous improvement activities and initiatives within work group. The candidate will understand and adhere to corporate standards regarding code of conduct, safety and GXP compliance.
Job Description The Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. During lead optimization and through candidate selection, MPDD scientists utilize state of the art automation and computational tools supported by expertise in biopharmaceutics, drug delivery, and solid-state chemistry to collaboratively progress candidates with higher probability of success into development and advise clinical formulation strategy. From candidate selection through clinical proof of concept and product launch, MPDD scientists work in cross functional teams to identify the commercial solid form of the active pharmaceutical ingredient (API) and establish structure-property-performance correlations to help deliver robust commercial processes and align control strategies across drug substance and product. They also transition drug substance isolation processes and relevant physical characterization methods to commercial manufacturing sites and work within teams to ensure successful regulatory submissions. Drug Delivery scientists within AbbVie's MPDD organization work collaboratively with other functions within Development Sciences and Discovery to conduct developability assessment to select molecules with higher probability of success for clinical development and eventual commercialization. This includes profiling of physicochemical properties, development of preclinical formulations, identifying solutions to in vivo absorption challenges, and advancement of novel drug delivery strategies across multiple routes of administration that are aligned with program target product profiles and downstream partners. Modalities of interest include traditional small molecules as well as complex chemically synthesized modalities such as PROTACs and peptides. In this role, you will work in cross-functional teams in matrixed environments and engage in multidisciplinary problem solving. Job Description AbbVie's MPDD organization is seeking a highly motivated, talented, and creative scientist with expertise and some experience in pharmaceutical sciences and drug delivery for a Senior Scientist II position. The primary role of this position is to serve as an MPDD project leader on discovery programs, leading CMC developability assessment for emerging molecules on small molecule pipeline programs. This role will also entail contributing towards developing our drug delivery capabilities with a focus on complex chemically synthesized modalities such as PROTACS and peptides. This person will be working collaboratively with discovery and development partners across disciplines to improve delivery of these modalities and advance molecules to clinical development with improved developability profiles. The desired candidate will have a strong background and hand-on experience in the areas of physicochemical and/or biophysical properties and their impact on developability, preclinical and/or clinical formulation, biopharmaceutics, and drug delivery concepts relevant to small molecules and peptides.
04/06/2024
Full time
Job Description The Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. During lead optimization and through candidate selection, MPDD scientists utilize state of the art automation and computational tools supported by expertise in biopharmaceutics, drug delivery, and solid-state chemistry to collaboratively progress candidates with higher probability of success into development and advise clinical formulation strategy. From candidate selection through clinical proof of concept and product launch, MPDD scientists work in cross functional teams to identify the commercial solid form of the active pharmaceutical ingredient (API) and establish structure-property-performance correlations to help deliver robust commercial processes and align control strategies across drug substance and product. They also transition drug substance isolation processes and relevant physical characterization methods to commercial manufacturing sites and work within teams to ensure successful regulatory submissions. Drug Delivery scientists within AbbVie's MPDD organization work collaboratively with other functions within Development Sciences and Discovery to conduct developability assessment to select molecules with higher probability of success for clinical development and eventual commercialization. This includes profiling of physicochemical properties, development of preclinical formulations, identifying solutions to in vivo absorption challenges, and advancement of novel drug delivery strategies across multiple routes of administration that are aligned with program target product profiles and downstream partners. Modalities of interest include traditional small molecules as well as complex chemically synthesized modalities such as PROTACs and peptides. In this role, you will work in cross-functional teams in matrixed environments and engage in multidisciplinary problem solving. Job Description AbbVie's MPDD organization is seeking a highly motivated, talented, and creative scientist with expertise and some experience in pharmaceutical sciences and drug delivery for a Senior Scientist II position. The primary role of this position is to serve as an MPDD project leader on discovery programs, leading CMC developability assessment for emerging molecules on small molecule pipeline programs. This role will also entail contributing towards developing our drug delivery capabilities with a focus on complex chemically synthesized modalities such as PROTACS and peptides. This person will be working collaboratively with discovery and development partners across disciplines to improve delivery of these modalities and advance molecules to clinical development with improved developability profiles. The desired candidate will have a strong background and hand-on experience in the areas of physicochemical and/or biophysical properties and their impact on developability, preclinical and/or clinical formulation, biopharmaceutics, and drug delivery concepts relevant to small molecules and peptides.
Overview Weatherford is a leading global energy services company. Our world-class experts partner with customers to optimize their resources and realize the full potential of their assets. Across our operating locations, including manufacturing, research and development, service, and training facilities, operators choose us for strategic solutions that add efficiency, flexibility, and responsibility to any energy operation. We are focused on technology development, digital solutions, and defining our footprint in the new energy space. Our ability to provide integrated solutions across our segments will be critical to growth in our core operations and the energy transition. Energy producers face unique challenges every day, so it is our job to create solutions that enhance safety, streamline operations, and sustain uptime to meet or exceed their targets. We operate across the global energy landscape employing some of the best diverse talent in the industry. At Weatherford, we understand the value each individual brings to the table. We celebrate diversity in all its forms and are immensely proud of our workforce. We invite you to join our passionate, talented, word-class team. When you join Weatherford, you instantly feel connected to something bigger - a community that is grounded by our core values and driven to create innovative solutions for our customers. We celebrate each other's successes, grow together, and learn from each other constantly. Individually, we are impressive. Together, we are unstoppable. We are One Weatherford. Weatherford offers competitive compensation, a comprehensive benefits program and provides you a challenging and enriching career path, with a healthy balance of structure and flexibility to chart your own course. Weatherford is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, religion, national or ethnic origin, sex, sexual orientation, gender identity or expression, age, disability, protected veteran status or other characteristics protected by law. Responsibilities Weatherford is hiring a Data Science Lead for our Spencer Road Research & Development facility in Houston, TX. We are looking for a motivated Data Science Technical Lead to help develop and enhance market-leading AI/ML solutions for the energy industry. This role requires collaborating with Product Management to identify and define problems that are best solved by AI/ML. The Data Science Technical Lead works with the team to define the requirements, quality measures, and solution approach and provides oversight and guidance to other data scientists to develop the solution. DUTIES & RESPONSIBILITIES: (not listed in any particular order) Based upon understanding of customer needs and input from stakeholders, such as Product Management, Sales, Support, and Services, identify opportunities for Data Science solutions in the Production Software space. Lead requirements gathering, requirements analysis, and requirements definition for AI/ML solutions. Assist with determining project timelines. Provide oversight to the data science team for the data science approach in the development of AI/ML solutions and products. Identify third-party data science tools, applications, and frameworks that will improve efficiencies and accelerate the development of AI/ML solutions. Assist with the definition and prioritization of enhancements, features, and bug fixes. Determine conditions of satisfaction and acceptance criteria for requirements. Assist with defining, improving, and ensuring adherence to the software development process including a process and framework for developing AI/ML solutions. Engage with customers and stakeholders to address complaints and issues and gain feedback. Demonstrate AI/ML solutions to internal and external users. Assist with coordinating and executing pilots and trials of AI/ML solutions. Assist with the creation and review of user manuals, release notes, and help documentation. Assist with the creation and review of user manuals, release notes, and help documentation. Qualifications Required: Bachelors in computer science, mathematics, statistics, or a related field. Minimum of 8 years of experience in Data Science or related field. This position is open to fully remote candidates located outside the Houston area. However, for candidates located in the Houston area, hybrid schedule is required. Must be authorized to work in the US with no sponsorship. Knowledge and experience applying Data Science to industrial applications. Experience integrating Data Science solutions with software products. Demonstrated ability of working with Product Management to formulate product plans and road maps and work with development organization to execute those plans and road maps. Experience directing the efforts of other data scientists. Ability to communicate data science, complex problems, solutions, and technologies in an understandable manner to non-subject matter experts. Ability to work with service and support organizations to prioritize defects to meet business needs. Ability to drive teams to deliver on timelines with quality. Ability to work in a globally distributed team environment. Preferred: Master's or PhD in Engineering computer science, mathematics, statistics, or a related field. Previous experience developing commercial software solutions. Experience working in an Agile software development environment. Experience in developing engineering software in the energy industry.
04/05/2024
Full time
Overview Weatherford is a leading global energy services company. Our world-class experts partner with customers to optimize their resources and realize the full potential of their assets. Across our operating locations, including manufacturing, research and development, service, and training facilities, operators choose us for strategic solutions that add efficiency, flexibility, and responsibility to any energy operation. We are focused on technology development, digital solutions, and defining our footprint in the new energy space. Our ability to provide integrated solutions across our segments will be critical to growth in our core operations and the energy transition. Energy producers face unique challenges every day, so it is our job to create solutions that enhance safety, streamline operations, and sustain uptime to meet or exceed their targets. We operate across the global energy landscape employing some of the best diverse talent in the industry. At Weatherford, we understand the value each individual brings to the table. We celebrate diversity in all its forms and are immensely proud of our workforce. We invite you to join our passionate, talented, word-class team. When you join Weatherford, you instantly feel connected to something bigger - a community that is grounded by our core values and driven to create innovative solutions for our customers. We celebrate each other's successes, grow together, and learn from each other constantly. Individually, we are impressive. Together, we are unstoppable. We are One Weatherford. Weatherford offers competitive compensation, a comprehensive benefits program and provides you a challenging and enriching career path, with a healthy balance of structure and flexibility to chart your own course. Weatherford is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, religion, national or ethnic origin, sex, sexual orientation, gender identity or expression, age, disability, protected veteran status or other characteristics protected by law. Responsibilities Weatherford is hiring a Data Science Lead for our Spencer Road Research & Development facility in Houston, TX. We are looking for a motivated Data Science Technical Lead to help develop and enhance market-leading AI/ML solutions for the energy industry. This role requires collaborating with Product Management to identify and define problems that are best solved by AI/ML. The Data Science Technical Lead works with the team to define the requirements, quality measures, and solution approach and provides oversight and guidance to other data scientists to develop the solution. DUTIES & RESPONSIBILITIES: (not listed in any particular order) Based upon understanding of customer needs and input from stakeholders, such as Product Management, Sales, Support, and Services, identify opportunities for Data Science solutions in the Production Software space. Lead requirements gathering, requirements analysis, and requirements definition for AI/ML solutions. Assist with determining project timelines. Provide oversight to the data science team for the data science approach in the development of AI/ML solutions and products. Identify third-party data science tools, applications, and frameworks that will improve efficiencies and accelerate the development of AI/ML solutions. Assist with the definition and prioritization of enhancements, features, and bug fixes. Determine conditions of satisfaction and acceptance criteria for requirements. Assist with defining, improving, and ensuring adherence to the software development process including a process and framework for developing AI/ML solutions. Engage with customers and stakeholders to address complaints and issues and gain feedback. Demonstrate AI/ML solutions to internal and external users. Assist with coordinating and executing pilots and trials of AI/ML solutions. Assist with the creation and review of user manuals, release notes, and help documentation. Assist with the creation and review of user manuals, release notes, and help documentation. Qualifications Required: Bachelors in computer science, mathematics, statistics, or a related field. Minimum of 8 years of experience in Data Science or related field. This position is open to fully remote candidates located outside the Houston area. However, for candidates located in the Houston area, hybrid schedule is required. Must be authorized to work in the US with no sponsorship. Knowledge and experience applying Data Science to industrial applications. Experience integrating Data Science solutions with software products. Demonstrated ability of working with Product Management to formulate product plans and road maps and work with development organization to execute those plans and road maps. Experience directing the efforts of other data scientists. Ability to communicate data science, complex problems, solutions, and technologies in an understandable manner to non-subject matter experts. Ability to work with service and support organizations to prioritize defects to meet business needs. Ability to drive teams to deliver on timelines with quality. Ability to work in a globally distributed team environment. Preferred: Master's or PhD in Engineering computer science, mathematics, statistics, or a related field. Previous experience developing commercial software solutions. Experience working in an Agile software development environment. Experience in developing engineering software in the energy industry.
MS&T Scientist III As the MS&T Scientist III, the successful candidate will work on significant technical/scientific project activities to execute strategies and technical solutions that meet companys and their clients needs and expectations through broad expertise. The successful candidate will be expected to maintain a high level of expertise within their field and engages in creation of processes and equipment design for clinical, scale up, and/or registration batches, including technology transfer of projects from client sites. Assume technical ownership of a given product across the various stages of development and commercialization in coordination with other functional areas. The MS&T Scientist III will be responsible for designing, leading, and executing studies to support product and process optimization and automation, investigation on deviation and root cause analysis; technology transfer activities, and product characterization studies, and any other activities required by the MS&T organization. RESPONSIBILITIES * Utilize and apply knowledge of basic scientific principles, theories and concepts to develop solutions to problems of moderate to high complexity.Lead multidisciplinary teams in developing and implementing solutions. * Perform site transfer activities to company from business partner locations and provide scientifically sound development reports. * Develop and optimize manufacturing processes for clinical, registration and commercial scale batches for sterile and non-sterile formulations. * Prepare and review Master Batch Records for experimental/engineering, registration, scale-up and process validation batches. * Prepare robust pharmaceutical/process development reports and other CMC documentation for regulatory submissions and represent company as SME during internal/external regulatory audits. * Use statistical process control and other statistical tools for comparison and hypothesis testing. Apply engineering, pharmaceutical sciences or materials sciences fundamentals to model the product and process to solve complex technical problems. * Evaluate and implement advance technologies for process evaluations and optimization (e.g., Process Analytical Technology, electronic batch records etc.) * Review and provide inputs for validation master plans, validation protocols, validation reports, continued process verification (CPV) plans and statistical sampling plans, among other important strategic documents. * Acts as internal/external Subject Matter Expert (SME) for drug product and process related technical issues and provide technical support to Formulation, Manufacturing, and Quality. * Identify potential root causes of variation and deviations using a systematic approach. Expertise in use / application of variety of problem-solving tools e.g. Ishikawa, Kepner-Tregoe (KT), five-whys, etc. and lead technical Deviation write-ups and CAPA assignments. * Work closely with process engineering team to develop robust user requirement documents for process equipment including manufacturing and packaging. * Provide technical input to management team regarding site capacity to evaluate new projects. * Lead and guide other scientists/associates in process development and manufacturing. QUALIFICATIONS * Experience in cGMP manufacture of commercial or late phase clinical products. * Experience with technology transfer and scale up * Familiarity with statistical process control (SPC), complex data analysis, mathematical modeling, and optimization software (like MiniTab, JMP, etc.) is a must. * Knowledge and experience in cGMP, risk assessment and investigation tools and techniques. * Able to work on multiple projects simultaneously. Familiarity with project management concepts is preferred. * Proficiency with Quality by Design (QbD) concepts and design of experiments required. * Demonstrated ability to provide scientific input and make decisions to resolve problems with minimal supervision. * BS/MS/PhD in pharmaceutical sciences/chemistry (or related field like organic, physical, biochemical, chemical engineering) with 6+ years (BS,), 4+ years (MS) or 2+ years (Ph.D.) industrial GMP experience.
11/08/2021
Full time
MS&T Scientist III As the MS&T Scientist III, the successful candidate will work on significant technical/scientific project activities to execute strategies and technical solutions that meet companys and their clients needs and expectations through broad expertise. The successful candidate will be expected to maintain a high level of expertise within their field and engages in creation of processes and equipment design for clinical, scale up, and/or registration batches, including technology transfer of projects from client sites. Assume technical ownership of a given product across the various stages of development and commercialization in coordination with other functional areas. The MS&T Scientist III will be responsible for designing, leading, and executing studies to support product and process optimization and automation, investigation on deviation and root cause analysis; technology transfer activities, and product characterization studies, and any other activities required by the MS&T organization. RESPONSIBILITIES * Utilize and apply knowledge of basic scientific principles, theories and concepts to develop solutions to problems of moderate to high complexity.Lead multidisciplinary teams in developing and implementing solutions. * Perform site transfer activities to company from business partner locations and provide scientifically sound development reports. * Develop and optimize manufacturing processes for clinical, registration and commercial scale batches for sterile and non-sterile formulations. * Prepare and review Master Batch Records for experimental/engineering, registration, scale-up and process validation batches. * Prepare robust pharmaceutical/process development reports and other CMC documentation for regulatory submissions and represent company as SME during internal/external regulatory audits. * Use statistical process control and other statistical tools for comparison and hypothesis testing. Apply engineering, pharmaceutical sciences or materials sciences fundamentals to model the product and process to solve complex technical problems. * Evaluate and implement advance technologies for process evaluations and optimization (e.g., Process Analytical Technology, electronic batch records etc.) * Review and provide inputs for validation master plans, validation protocols, validation reports, continued process verification (CPV) plans and statistical sampling plans, among other important strategic documents. * Acts as internal/external Subject Matter Expert (SME) for drug product and process related technical issues and provide technical support to Formulation, Manufacturing, and Quality. * Identify potential root causes of variation and deviations using a systematic approach. Expertise in use / application of variety of problem-solving tools e.g. Ishikawa, Kepner-Tregoe (KT), five-whys, etc. and lead technical Deviation write-ups and CAPA assignments. * Work closely with process engineering team to develop robust user requirement documents for process equipment including manufacturing and packaging. * Provide technical input to management team regarding site capacity to evaluate new projects. * Lead and guide other scientists/associates in process development and manufacturing. QUALIFICATIONS * Experience in cGMP manufacture of commercial or late phase clinical products. * Experience with technology transfer and scale up * Familiarity with statistical process control (SPC), complex data analysis, mathematical modeling, and optimization software (like MiniTab, JMP, etc.) is a must. * Knowledge and experience in cGMP, risk assessment and investigation tools and techniques. * Able to work on multiple projects simultaneously. Familiarity with project management concepts is preferred. * Proficiency with Quality by Design (QbD) concepts and design of experiments required. * Demonstrated ability to provide scientific input and make decisions to resolve problems with minimal supervision. * BS/MS/PhD in pharmaceutical sciences/chemistry (or related field like organic, physical, biochemical, chemical engineering) with 6+ years (BS,), 4+ years (MS) or 2+ years (Ph.D.) industrial GMP experience.
What we offer You will work on exciting and challenging topics together with a team in an ultra-modern, innovative and creative environment. Intensive on-the-job training with expert colleagues guarantees you will quickly become familiar with your duties and perform them independently. Performance related pay and the opportunity for personal and professional development are of course part of the package. Since 2009 Evonik Industries AG has been certified as a family-friendly company by the German Hertie Foundation. Click here to learn more about Evonik from our employees Evonik's Health Care Business Line includes a fast growing portfolio of products, services and technologies for the cell culture and biopharmaceutical industries. The Business Development Manager - Cell Culture position is critical to the continued growth and success of the cell culture and biopharmaceutical business in North America. The position will be focused prospecting and lead generation for new business, growing some existing accounts, and looking for strategic/innovative development opportunities in new markets for existing products and new products for Evonik's biopharma and cell culture segment. RESPONSIBILITIES Business Development: Prospecting and Lead Generation. Identify new opportunities and build relationships at companies developing and marketing cell culture media, cell culture contract manufacturers and biopharmaceutical companies within assigned regions. Negotiate contracts (non-disclosure agreements, supply agreements, service agreements, material transfer agreements, quality agreements, etc.) as necessary. Internal support will vary depending on the type of agreements and could include IP, legal support, quality/regulatory and business development groups. Account Management: Responsible for revenue and contribution margin from products at newly developed customers. Develop short and long term forecasts and business plans to further develop these accounts. Market Analysis & Intelligence: Identify key trends and needs in this industry to introduce the usage of Evonik portfolio of products, services and technologies. Determine additional products, features etc. needed to differentiate Evonik from other competition In collaboration with the product line, support the development of market strategy and recommend strategic actions and potential partnerships in all steps of the value chain. Marketing & Communications: Identify and participate in relevant conferences, technical seminars, trade meetings, etc. to make new contacts and identify new development opportunities Contribute actively to the science-based communication via social media, trade journals Actively communicate with Health Care team via timely distribution of call reports, maintenance of product and service pipeline projects, and other reporting. Work with the product line and other internal stakeholders to prepare marketing promotional programs at the assigned accounts. REQUIREMENTS Bachelor's degree required, engineering degree preferred. Advanced degree a plus. Minimum 5 years of proven sales track record in cell culture media and/or media ingredients with proven experience in prospecting and lead generation including experience selling products, services and technologies (ie - licensing / royalty deals). Technical and application knowledge of cell culture media, cell culture manufacturing and operations, and biopharmaceutical development and manufacturing. Strong technical background with an ability to engage in technical discussions with scientists and engineers developing new products. Must have the ability to build and expand relationships with customers and prospects, and be comfortable calling on a variety of companies, technical and supply chain contacts, as well as all levels of management. Excellent communication, presentation, and interpersonal skills Ideally possess established relationships with contacts in the biopharmaceutical and cell culture industry. Contract negotiation skills (confidentiality, supply, service, licensing and quality agreements). Ability to self-motivate, maintain high level of organization, and coordinate many projects simultaneously. Proven track record of effective prospecting and lead generation. Your Application To ensure the fastest process of your application and to protect the environment, please apply online via our careers portal at . VACANCY REFERENCE NUMBER 139598 Evonik Corporation is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, gender, sexual orientation, national origin, disability status, protected veteran status or any other legally protected status. Please note that Evonik will not accept any unsolicited application documents sent by staffing firms. Evonik works in conjunction with preferred service providers and will not pay any fee to staffing firms in the absence of an appropriate framework agreement. Should Evonik receive a candidate profile from a staffing firm with which it has no framework agreement, and should this candidate subsequently be considered in the recruitment process or offered employment, no claims from the staffing firm will be entertained in this regard.
11/04/2021
Full time
What we offer You will work on exciting and challenging topics together with a team in an ultra-modern, innovative and creative environment. Intensive on-the-job training with expert colleagues guarantees you will quickly become familiar with your duties and perform them independently. Performance related pay and the opportunity for personal and professional development are of course part of the package. Since 2009 Evonik Industries AG has been certified as a family-friendly company by the German Hertie Foundation. Click here to learn more about Evonik from our employees Evonik's Health Care Business Line includes a fast growing portfolio of products, services and technologies for the cell culture and biopharmaceutical industries. The Business Development Manager - Cell Culture position is critical to the continued growth and success of the cell culture and biopharmaceutical business in North America. The position will be focused prospecting and lead generation for new business, growing some existing accounts, and looking for strategic/innovative development opportunities in new markets for existing products and new products for Evonik's biopharma and cell culture segment. RESPONSIBILITIES Business Development: Prospecting and Lead Generation. Identify new opportunities and build relationships at companies developing and marketing cell culture media, cell culture contract manufacturers and biopharmaceutical companies within assigned regions. Negotiate contracts (non-disclosure agreements, supply agreements, service agreements, material transfer agreements, quality agreements, etc.) as necessary. Internal support will vary depending on the type of agreements and could include IP, legal support, quality/regulatory and business development groups. Account Management: Responsible for revenue and contribution margin from products at newly developed customers. Develop short and long term forecasts and business plans to further develop these accounts. Market Analysis & Intelligence: Identify key trends and needs in this industry to introduce the usage of Evonik portfolio of products, services and technologies. Determine additional products, features etc. needed to differentiate Evonik from other competition In collaboration with the product line, support the development of market strategy and recommend strategic actions and potential partnerships in all steps of the value chain. Marketing & Communications: Identify and participate in relevant conferences, technical seminars, trade meetings, etc. to make new contacts and identify new development opportunities Contribute actively to the science-based communication via social media, trade journals Actively communicate with Health Care team via timely distribution of call reports, maintenance of product and service pipeline projects, and other reporting. Work with the product line and other internal stakeholders to prepare marketing promotional programs at the assigned accounts. REQUIREMENTS Bachelor's degree required, engineering degree preferred. Advanced degree a plus. Minimum 5 years of proven sales track record in cell culture media and/or media ingredients with proven experience in prospecting and lead generation including experience selling products, services and technologies (ie - licensing / royalty deals). Technical and application knowledge of cell culture media, cell culture manufacturing and operations, and biopharmaceutical development and manufacturing. Strong technical background with an ability to engage in technical discussions with scientists and engineers developing new products. Must have the ability to build and expand relationships with customers and prospects, and be comfortable calling on a variety of companies, technical and supply chain contacts, as well as all levels of management. Excellent communication, presentation, and interpersonal skills Ideally possess established relationships with contacts in the biopharmaceutical and cell culture industry. Contract negotiation skills (confidentiality, supply, service, licensing and quality agreements). Ability to self-motivate, maintain high level of organization, and coordinate many projects simultaneously. Proven track record of effective prospecting and lead generation. Your Application To ensure the fastest process of your application and to protect the environment, please apply online via our careers portal at . VACANCY REFERENCE NUMBER 139598 Evonik Corporation is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, gender, sexual orientation, national origin, disability status, protected veteran status or any other legally protected status. Please note that Evonik will not accept any unsolicited application documents sent by staffing firms. Evonik works in conjunction with preferred service providers and will not pay any fee to staffing firms in the absence of an appropriate framework agreement. Should Evonik receive a candidate profile from a staffing firm with which it has no framework agreement, and should this candidate subsequently be considered in the recruitment process or offered employment, no claims from the staffing firm will be entertained in this regard.
Allogene Therapeutics
South San Francisco, California
About Allogene Therapeutics, Inc:Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T) therapies for cancer. Led by a management team with significant experience in cell therapy, Allogene is developing a pipeline of off-the-shelf CAR T cell therapy candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. For more information, please visit , and on Twitter and LinkedIn.Job Description:Allogene is looking for a seasoned, broadly trained scientist and manager to oversee the external quality Control (QC) testing laboratory operations supporting the CAR T products clinical and commercial manufacturing. Allogene plans to create an outstanding product design, characterization and qualification capability in the allogeneic cell therapy space. The candidate will support the QC organization in ensuring the readiness of QC contract testing laboratories (CTL) for the seamless execution of release and stability testing within agreed upon timeline to meet clinical demands according to plan and budget. The candidate will support the QC head and partner with External Quality Assurance (QA), as well as external partners in defining laboratory systems and processes for the compliant operation of this external QC laboratory network, defining and tracking key performance indicators, and resolving issues as they arise. The candidate will maintain strong connections with the internal Allogene QC laboratories ensuring alignment on requirements for methods, critical reagents, and instruments as needed. The role will entail operating in a fast-paced, highly dynamic environment with company work partnerships including both internal and external stakeholders. This role will report to the Head of QC.Responsibilities include, but are not limited to: Provides leadership, management and technical oversight for the successful execution of release and stability testing at various CTL within agreed upon turnaround-time (TAT) and within budget. Responsible for the review of CTL data, ensuring that they are maintained in compliance with regulatory and Allogenes requirements. Coordinates with Allogene laboratory heads and CTL the maintenance and management of critical laboratory reagents, standards and controls ensuring uninterrupted operation. Establishes processes to trend methods performance at CTL over time. Align with internal Allogene laboratories on control materials and performance as needed. Ensures, where applicable, alignment on instrument requirements/equivalency between Allogene and CTL. Keeps current with revisions to test methods at Allogene and CTL. Where applicable, revises methods and related documentation per established change management procedures at Allogene and CTL. Aligns and coordinates with stability manager on stability samples testing to ensure timely execution and adherence to stability studies schedules. Manages performance of CTL by tracking and ensuring established KPI are met. Escalates CTL performance issues to management in a timely manner. Actively manage CTL associated costs and ensure compliance with budget goals. Oversees validation/verification of methods for CAR T products and raw materials at CTL ensuring compliance with regulatory requirements. Provides direction and guidance to authors of method validations/verifications protocols and reports and evaluate data generated from these activities. Investigates and oversees validation exception reports where needed. In collaboration with Allogene laboratory heads and Head of Infrastructure Support and Methods Life Cycle, oversees technical transfer of CAR T and raw materials methods to and from CTL in line with regulatory requirements and per project timeline and budget. Establishes new and improves existing processes for transfer ensuring cross functional alignment with stakeholders across sites Provides technical guidance and management support for testing related nonconformance events, associated corrective and preventative actions and change control. Collaborates effectively with Allogene External QA to manage the initiation, evaluation, and closure of nonconformance events and CAPA implementation plans at CTL. Investigates unexpected/Out of Specification/Out of Trend test results. Helps define investigation/re-test plans, where applicable. Collaborates effectively with Allogenes and the CTLs QA representatives to manage the initiation, investigation, and compliant closure of these events. Authors and reviews technical registration documents and other sections of regulatory submissions pertaining to methods executed at CTL. Supports Allogene inspections and audits at CTL sites as well as internal Allogene regulatory inspections as the CTL liaison. Supports external QA in ensuring CTL are ready for GMP and pre-approval inspections (PAI). Collaborates cross functionally and builds relationships with external CTL and within Allogene QC, QA, Regulatory Affairs, Development, Manufacturing and Supply Chain to meet target milestones. Be able to negotiate, influence, and work in a matrix environment and across sites. Manages multiple projects, set priorities, and work in a fast-paced environment. Able to negotiate, influence, and work in a matrix environment. Other duties as assignedPosition Requirements & Experience: M.S./B.S. Degree, Ph.D. is a plus. Minimum 6-8 years of analytical development/QC laboratory experience in biotechnology with 2-4 years in a management role. Experience with analytical and biochemical methods including but not limited to cell-based assays/techniques including FACS analysis, potency testing, and immunofluorescence, molecular biology methodologies including but not limited to DNA, RNA manipulation and PCR, ELISA/HTRF, as well as electrophoresis/western blot analysis. Experience with HPLC systems is a plus. Experience with microbiological tests including compendial sterility testing, mycoplasma, endotoxin and viral testing. Strong understanding of GMP requirements and QC systems Experience with method development, validation and transfer Experience in dealing with regulatory agencies, supporting GMP and PAI inspections as well as experience with regulatory filings. Strong leadership ability, interpersonal, communication, and influencing skills required. Highly collaborative with the proven ability to work in a cross-functional team. Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines. Ability to work independently and as part of a team. Strong interpersonal skills including verbal and written communication are essential in this collaborative work environment. Expected to travel 15-20% of time. Candidates must be authorized to work in the U.S. Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonablyAs an equal opportunity employer, Allogene Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws.#LI-EL1
08/31/2021
Full time
About Allogene Therapeutics, Inc:Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T) therapies for cancer. Led by a management team with significant experience in cell therapy, Allogene is developing a pipeline of off-the-shelf CAR T cell therapy candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. For more information, please visit , and on Twitter and LinkedIn.Job Description:Allogene is looking for a seasoned, broadly trained scientist and manager to oversee the external quality Control (QC) testing laboratory operations supporting the CAR T products clinical and commercial manufacturing. Allogene plans to create an outstanding product design, characterization and qualification capability in the allogeneic cell therapy space. The candidate will support the QC organization in ensuring the readiness of QC contract testing laboratories (CTL) for the seamless execution of release and stability testing within agreed upon timeline to meet clinical demands according to plan and budget. The candidate will support the QC head and partner with External Quality Assurance (QA), as well as external partners in defining laboratory systems and processes for the compliant operation of this external QC laboratory network, defining and tracking key performance indicators, and resolving issues as they arise. The candidate will maintain strong connections with the internal Allogene QC laboratories ensuring alignment on requirements for methods, critical reagents, and instruments as needed. The role will entail operating in a fast-paced, highly dynamic environment with company work partnerships including both internal and external stakeholders. This role will report to the Head of QC.Responsibilities include, but are not limited to: Provides leadership, management and technical oversight for the successful execution of release and stability testing at various CTL within agreed upon turnaround-time (TAT) and within budget. Responsible for the review of CTL data, ensuring that they are maintained in compliance with regulatory and Allogenes requirements. Coordinates with Allogene laboratory heads and CTL the maintenance and management of critical laboratory reagents, standards and controls ensuring uninterrupted operation. Establishes processes to trend methods performance at CTL over time. Align with internal Allogene laboratories on control materials and performance as needed. Ensures, where applicable, alignment on instrument requirements/equivalency between Allogene and CTL. Keeps current with revisions to test methods at Allogene and CTL. Where applicable, revises methods and related documentation per established change management procedures at Allogene and CTL. Aligns and coordinates with stability manager on stability samples testing to ensure timely execution and adherence to stability studies schedules. Manages performance of CTL by tracking and ensuring established KPI are met. Escalates CTL performance issues to management in a timely manner. Actively manage CTL associated costs and ensure compliance with budget goals. Oversees validation/verification of methods for CAR T products and raw materials at CTL ensuring compliance with regulatory requirements. Provides direction and guidance to authors of method validations/verifications protocols and reports and evaluate data generated from these activities. Investigates and oversees validation exception reports where needed. In collaboration with Allogene laboratory heads and Head of Infrastructure Support and Methods Life Cycle, oversees technical transfer of CAR T and raw materials methods to and from CTL in line with regulatory requirements and per project timeline and budget. Establishes new and improves existing processes for transfer ensuring cross functional alignment with stakeholders across sites Provides technical guidance and management support for testing related nonconformance events, associated corrective and preventative actions and change control. Collaborates effectively with Allogene External QA to manage the initiation, evaluation, and closure of nonconformance events and CAPA implementation plans at CTL. Investigates unexpected/Out of Specification/Out of Trend test results. Helps define investigation/re-test plans, where applicable. Collaborates effectively with Allogenes and the CTLs QA representatives to manage the initiation, investigation, and compliant closure of these events. Authors and reviews technical registration documents and other sections of regulatory submissions pertaining to methods executed at CTL. Supports Allogene inspections and audits at CTL sites as well as internal Allogene regulatory inspections as the CTL liaison. Supports external QA in ensuring CTL are ready for GMP and pre-approval inspections (PAI). Collaborates cross functionally and builds relationships with external CTL and within Allogene QC, QA, Regulatory Affairs, Development, Manufacturing and Supply Chain to meet target milestones. Be able to negotiate, influence, and work in a matrix environment and across sites. Manages multiple projects, set priorities, and work in a fast-paced environment. Able to negotiate, influence, and work in a matrix environment. Other duties as assignedPosition Requirements & Experience: M.S./B.S. Degree, Ph.D. is a plus. Minimum 6-8 years of analytical development/QC laboratory experience in biotechnology with 2-4 years in a management role. Experience with analytical and biochemical methods including but not limited to cell-based assays/techniques including FACS analysis, potency testing, and immunofluorescence, molecular biology methodologies including but not limited to DNA, RNA manipulation and PCR, ELISA/HTRF, as well as electrophoresis/western blot analysis. Experience with HPLC systems is a plus. Experience with microbiological tests including compendial sterility testing, mycoplasma, endotoxin and viral testing. Strong understanding of GMP requirements and QC systems Experience with method development, validation and transfer Experience in dealing with regulatory agencies, supporting GMP and PAI inspections as well as experience with regulatory filings. Strong leadership ability, interpersonal, communication, and influencing skills required. Highly collaborative with the proven ability to work in a cross-functional team. Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines. Ability to work independently and as part of a team. Strong interpersonal skills including verbal and written communication are essential in this collaborative work environment. Expected to travel 15-20% of time. Candidates must be authorized to work in the U.S. Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonablyAs an equal opportunity employer, Allogene Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws.#LI-EL1
Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for an Associate Director/Principal Scientist, Virology for our site in Malvern, PA. At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies. The candidate for this position will provide scientific leadership in the area of viral safety and be responsible for driving virology testing programs in raw materials, cell line characterization, unprocessed bulk testing and viral clearance studies to current industry standards and/or best practices. The candidate will provide technical review of external partners protocols, reports, methods, coordinate with and resolve issues with external laboratories and lead activities when required. Candidate may also manage direct reports. Responsibilities also include maintaining an awareness of current issues in viral safety for biopharmaceuticals, authoring technical documents, regulatory filings, supporting quality events and change controls, and contributing to technology transfer to collaboration partners. Responsible as a liaison with manufacturing sites quality control to provide technical oversight for clinical and commercial products. Knowledge of cell and gene therapy manufacturing and testing preferred. The candidate is expected to work in a team environment as well as contributing individually to meet project timeline and objectives. The position requires extensive expertise in virology, including familiarity with classical cell culture, nucleic acid testing methods and advanced viral detection systems. Requires substantial communication skills including experience with regulatory agencies, technical writing ability to ensure studies are performed properly and data presented in regulatory documents are understandable to the regulatory community. The candidate will act as a mentor, advisor, and technical subject matter expert to others in the company. Qualifications A PhD in Virology, Microbiology, Biological Sciences or Biochemistry with at least 6 years of relevant business experience OR at least 3 years of experience performing progressively advanced duties at the Senior Scientist level, or equivalent training/ experience is required with a minimum of a bachelor's degree. Knowledge and hands-on experience in cell culture, virology, and nucleic acid methods are required. Knowledge of cell therapy and gene therapy manufacturing, and testing preferred. Experience working in a GMP environment is preferred. CMC regulatory experience is preferred. Experience managing people preferred. The candidate must be highly organized and capable of managing/pursuing multiple projects independently. Good written and verbal communication skills are required. Experience maintaining written records of work in the form of (electronic) notebooks, technical reports and protocols is required. Data reporting, ability to present findings to management, and experience with team-based collaborations is a must. Occasional travel and weekend work may be required. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Primary Location United States-Pennsylvania-Malvern-200 Great Valley Parkway Organization Janssen Research & Development, LLC (6084) Job Function R&D Requisition ID W
08/30/2021
Full time
Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for an Associate Director/Principal Scientist, Virology for our site in Malvern, PA. At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies. The candidate for this position will provide scientific leadership in the area of viral safety and be responsible for driving virology testing programs in raw materials, cell line characterization, unprocessed bulk testing and viral clearance studies to current industry standards and/or best practices. The candidate will provide technical review of external partners protocols, reports, methods, coordinate with and resolve issues with external laboratories and lead activities when required. Candidate may also manage direct reports. Responsibilities also include maintaining an awareness of current issues in viral safety for biopharmaceuticals, authoring technical documents, regulatory filings, supporting quality events and change controls, and contributing to technology transfer to collaboration partners. Responsible as a liaison with manufacturing sites quality control to provide technical oversight for clinical and commercial products. Knowledge of cell and gene therapy manufacturing and testing preferred. The candidate is expected to work in a team environment as well as contributing individually to meet project timeline and objectives. The position requires extensive expertise in virology, including familiarity with classical cell culture, nucleic acid testing methods and advanced viral detection systems. Requires substantial communication skills including experience with regulatory agencies, technical writing ability to ensure studies are performed properly and data presented in regulatory documents are understandable to the regulatory community. The candidate will act as a mentor, advisor, and technical subject matter expert to others in the company. Qualifications A PhD in Virology, Microbiology, Biological Sciences or Biochemistry with at least 6 years of relevant business experience OR at least 3 years of experience performing progressively advanced duties at the Senior Scientist level, or equivalent training/ experience is required with a minimum of a bachelor's degree. Knowledge and hands-on experience in cell culture, virology, and nucleic acid methods are required. Knowledge of cell therapy and gene therapy manufacturing, and testing preferred. Experience working in a GMP environment is preferred. CMC regulatory experience is preferred. Experience managing people preferred. The candidate must be highly organized and capable of managing/pursuing multiple projects independently. Good written and verbal communication skills are required. Experience maintaining written records of work in the form of (electronic) notebooks, technical reports and protocols is required. Data reporting, ability to present findings to management, and experience with team-based collaborations is a must. Occasional travel and weekend work may be required. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Primary Location United States-Pennsylvania-Malvern-200 Great Valley Parkway Organization Janssen Research & Development, LLC (6084) Job Function R&D Requisition ID W
Obsidian Therapeutics is pioneering controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases. Obsidian's programs apply our CytoDriveTM technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Our Opportunity… We're looking for a leader in analytical development to contribute to building Obsidian's analytical sciences capabilities for process and product characterization, driving the development of the first autologous cell therapy product in our pipeline targeting cancer. This is a key role, focusing on molecular and immunological assay development. You'll work collaboratively with the Analytical Development team as well as Manufacturing, Process Development, Regulatory, and Quality functions to develop analytical tools for the characterization of viral vectors and cell therapy products to support our clinical pipeline. As part of our Technical Development and Manufacturing department, you'll be a vital part of working to achieve Obsidian's vision by collaboratively translating innovative science into medical breakthroughs for patients. This is a unique opportunity in a well-funded early-stage company with blue-chip investors, field-leading advisors, and a highly experienced team. You will help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need. Located in the heart of Cambridge, we're proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. We offer competitive salary and benefits, and potential for employee ownership through stock options. You Will… Apply your expertise in developing and qualifying analytical assays to support the release and characterization of viral vector and cell therapy products in early and later phases of development. Design, plan, and execute experiments in Analytical Development, working both independently and as part of a multidisciplinary team of researchers Support method development and provide technical expertise for the qualification of assays to assess identity, purity, safety and potency in engineered primary cells (eg TIL, T Cell, NK cell) and viral vectors (eg lentiviral vectors) Support introduction of new analytical technologies, implementation of common reagents and controls, trending of data, and generation of SOPs to support vector production, and transfer of analytical methods to CDMOs Interpret results, troubleshoot technical hurdles, and propose solutions to the team Maintain excellent records of experiments, including Electronic Notebook entries. Author and review technical and scientific documents including but not limited to study protocols and reports, validation documents, SOPs, and test methods Help build the team and mentor/train team members on experiment design, data analysis with adequate scientific rigor and proper documentation in lab notebooks and reports Collaborate effectively across Obsidian organization, present internally to project teams, management, and scientific teams. Represent analytical development in CMC sub-teams for assigned projects and support project activities including authoring of relevant CMC sections in regulatory documents You Bring…. Core Qualifications Ph.D. in a relevant discipline (immunology, biochemistry, cell biology, biotechnology or related field) and 3+ years relevant industry experience. or MS and 10+ years of relevant industry experience. Prior direct experience in viral vectors or cell therapy Demonstrated track record with analytical development supporting early and/or late-stage development of biologics Subject matter expertise in product characterization methods relevant to an immune cell-based product and viral vector starting materials, with a focus on molecular and immunoassay development (PCR / qPCR, ddPCR, ELISA, MSD and western blot) Strong troubleshooting and communication skills, highly organized with strong record-keeping and an ability to multi-task Highly collaborative working style and ability to adapt in a fast paced, rapidly developing environment Ability to work with minimal direction to meet objectives and timelines, adapting to changes and priorities in order to fulfill our mission Bonus Qualifications Demonstrated track record with analytical development and method qualification for characterization of engineered cell therapies or viral vectors Experience with multi-parameter flow cytometry assays, cell line/ primary cell transduction/ transfection, and cell-based assay development Experience with Design of Experiment (DOE) approaches and application to analytical development Experience working with CDMOs/ CTLs for method transfer/ development/ qualification/ validation Familiarity with FDA and EMA guidance documents relevant to gene and cell therapy analytical development and method validation
03/23/2021
Full time
Obsidian Therapeutics is pioneering controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases. Obsidian's programs apply our CytoDriveTM technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Our Opportunity… We're looking for a leader in analytical development to contribute to building Obsidian's analytical sciences capabilities for process and product characterization, driving the development of the first autologous cell therapy product in our pipeline targeting cancer. This is a key role, focusing on molecular and immunological assay development. You'll work collaboratively with the Analytical Development team as well as Manufacturing, Process Development, Regulatory, and Quality functions to develop analytical tools for the characterization of viral vectors and cell therapy products to support our clinical pipeline. As part of our Technical Development and Manufacturing department, you'll be a vital part of working to achieve Obsidian's vision by collaboratively translating innovative science into medical breakthroughs for patients. This is a unique opportunity in a well-funded early-stage company with blue-chip investors, field-leading advisors, and a highly experienced team. You will help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need. Located in the heart of Cambridge, we're proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. We offer competitive salary and benefits, and potential for employee ownership through stock options. You Will… Apply your expertise in developing and qualifying analytical assays to support the release and characterization of viral vector and cell therapy products in early and later phases of development. Design, plan, and execute experiments in Analytical Development, working both independently and as part of a multidisciplinary team of researchers Support method development and provide technical expertise for the qualification of assays to assess identity, purity, safety and potency in engineered primary cells (eg TIL, T Cell, NK cell) and viral vectors (eg lentiviral vectors) Support introduction of new analytical technologies, implementation of common reagents and controls, trending of data, and generation of SOPs to support vector production, and transfer of analytical methods to CDMOs Interpret results, troubleshoot technical hurdles, and propose solutions to the team Maintain excellent records of experiments, including Electronic Notebook entries. Author and review technical and scientific documents including but not limited to study protocols and reports, validation documents, SOPs, and test methods Help build the team and mentor/train team members on experiment design, data analysis with adequate scientific rigor and proper documentation in lab notebooks and reports Collaborate effectively across Obsidian organization, present internally to project teams, management, and scientific teams. Represent analytical development in CMC sub-teams for assigned projects and support project activities including authoring of relevant CMC sections in regulatory documents You Bring…. Core Qualifications Ph.D. in a relevant discipline (immunology, biochemistry, cell biology, biotechnology or related field) and 3+ years relevant industry experience. or MS and 10+ years of relevant industry experience. Prior direct experience in viral vectors or cell therapy Demonstrated track record with analytical development supporting early and/or late-stage development of biologics Subject matter expertise in product characterization methods relevant to an immune cell-based product and viral vector starting materials, with a focus on molecular and immunoassay development (PCR / qPCR, ddPCR, ELISA, MSD and western blot) Strong troubleshooting and communication skills, highly organized with strong record-keeping and an ability to multi-task Highly collaborative working style and ability to adapt in a fast paced, rapidly developing environment Ability to work with minimal direction to meet objectives and timelines, adapting to changes and priorities in order to fulfill our mission Bonus Qualifications Demonstrated track record with analytical development and method qualification for characterization of engineered cell therapies or viral vectors Experience with multi-parameter flow cytometry assays, cell line/ primary cell transduction/ transfection, and cell-based assay development Experience with Design of Experiment (DOE) approaches and application to analytical development Experience working with CDMOs/ CTLs for method transfer/ development/ qualification/ validation Familiarity with FDA and EMA guidance documents relevant to gene and cell therapy analytical development and method validation
Obsidian Therapeutics is pioneering controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases. Obsidian's programs apply our CytoDriveTM technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Our Opportunity… We're looking for a highly motivated scientist with a strong background in process development to contribute to building Vector Process Development capabilities for Obsidian to drive the development of the engineered cell therapy products in our pipeline targeting cancer. In this role, you'll work with the Manufacturing, Cell Therapy Process Development, Analytical Development, Regulatory, and Quality functions to develop gene delivery processes to support Obsidian's engineered cell therapy clinical pipeline. As part of our Technical Development and Manufacturing department, you will be a vital part of a highly collaborative team working to achieve Obsidian's vision by translating innovative science into medical breakthroughs for patients. This is a unique opportunity in a well-funded early-stage company with blue-chip investors, field-leading advisors, and a highly experienced team. You will help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need. Located in the heart of Cambridge, we're proud of our diversely talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. We offer competitive salary and benefits, and potential for employee ownership through stock options. You Will… Apply your expertise in the development of processes for viral vector production to support engineered cell therapies. Assist with developing scalable and efficient viral vector production processes and materials for engineered cell therapies. Design, plan, and execute experiments in Vector Process Development, working both independently and as part of a multidisciplinary team of researchers Identify and implement solutions to address current technical challenges in viral vector (eg lentiviral and retroviral) production processes in collaboration with research to support engineered cell therapies Run and/or improve methods in collaboration with research and analytical development to characterize viral vector production methods and primary cell transduction Supply viral vector materials to support research studies, analytical development, and CDMO tech transfer activities Interpret results, troubleshoot technical hurdles, and propose solutions to the team Maintain excellent records of experiments, including Electronic Notebook entries, authoring of protocols, test methods, and study reports Collaborate effectively across the Obsidian organization, present internally to project teams, management, and scientific teams Maintain a safe work environment in accordance with policies/procedures/regulations You Bring… Core Qualifications BS or MS in a relevant discipline (eg chemical engineering, cellular and molecular biology, biotechnology) Minimum of 6-10 years relevant industry experience including prior direct experience in viral vector biology and/or production Demonstrated track record with different gene delivery methodologies, such as lentivirus/ retrovirus/ AAV supporting early-stage research and development of biologics Subject matter expertise in mammalian cell culture, including adherent and suspension cell culture scale-up/down and stable cell line development Subject matter expertise in viral vector production, including downstream purification and concentration methods (eg Tangential Flow Filtration) Familiar with product characterization methods relevant to viral vectors (e.g. cell line/primary cell transduction, titering, flow cytometry, qPCR/ ddPCR, ELISA, MSD, and western blot) Strong troubleshooting and communication skills Highly organized with strong record-keeping skills, and an ability to manage multiple tasks in parallel Highly collaborative working style Ability to work independently and as part of teams to meet deadlines in a fast-paced rapidly developing environment, prioritize work across multiple projects, and adapt to changes in order to fulfill our mission Bonus Qualifications Experience in process development supporting early and/ or late-stage development of biologics is highly desirable (cell therapy, gene therapy, vaccines, antibodies) Experience with Design of Experiment (DOE) approaches and application to process improvement Experience in technical transfer of processes to CDMOs Familiarity with FDA and EMA guidance documents relevant to gene and cell therapy is a plus
03/23/2021
Full time
Obsidian Therapeutics is pioneering controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases. Obsidian's programs apply our CytoDriveTM technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Our Opportunity… We're looking for a highly motivated scientist with a strong background in process development to contribute to building Vector Process Development capabilities for Obsidian to drive the development of the engineered cell therapy products in our pipeline targeting cancer. In this role, you'll work with the Manufacturing, Cell Therapy Process Development, Analytical Development, Regulatory, and Quality functions to develop gene delivery processes to support Obsidian's engineered cell therapy clinical pipeline. As part of our Technical Development and Manufacturing department, you will be a vital part of a highly collaborative team working to achieve Obsidian's vision by translating innovative science into medical breakthroughs for patients. This is a unique opportunity in a well-funded early-stage company with blue-chip investors, field-leading advisors, and a highly experienced team. You will help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need. Located in the heart of Cambridge, we're proud of our diversely talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. We offer competitive salary and benefits, and potential for employee ownership through stock options. You Will… Apply your expertise in the development of processes for viral vector production to support engineered cell therapies. Assist with developing scalable and efficient viral vector production processes and materials for engineered cell therapies. Design, plan, and execute experiments in Vector Process Development, working both independently and as part of a multidisciplinary team of researchers Identify and implement solutions to address current technical challenges in viral vector (eg lentiviral and retroviral) production processes in collaboration with research to support engineered cell therapies Run and/or improve methods in collaboration with research and analytical development to characterize viral vector production methods and primary cell transduction Supply viral vector materials to support research studies, analytical development, and CDMO tech transfer activities Interpret results, troubleshoot technical hurdles, and propose solutions to the team Maintain excellent records of experiments, including Electronic Notebook entries, authoring of protocols, test methods, and study reports Collaborate effectively across the Obsidian organization, present internally to project teams, management, and scientific teams Maintain a safe work environment in accordance with policies/procedures/regulations You Bring… Core Qualifications BS or MS in a relevant discipline (eg chemical engineering, cellular and molecular biology, biotechnology) Minimum of 6-10 years relevant industry experience including prior direct experience in viral vector biology and/or production Demonstrated track record with different gene delivery methodologies, such as lentivirus/ retrovirus/ AAV supporting early-stage research and development of biologics Subject matter expertise in mammalian cell culture, including adherent and suspension cell culture scale-up/down and stable cell line development Subject matter expertise in viral vector production, including downstream purification and concentration methods (eg Tangential Flow Filtration) Familiar with product characterization methods relevant to viral vectors (e.g. cell line/primary cell transduction, titering, flow cytometry, qPCR/ ddPCR, ELISA, MSD, and western blot) Strong troubleshooting and communication skills Highly organized with strong record-keeping skills, and an ability to manage multiple tasks in parallel Highly collaborative working style Ability to work independently and as part of teams to meet deadlines in a fast-paced rapidly developing environment, prioritize work across multiple projects, and adapt to changes in order to fulfill our mission Bonus Qualifications Experience in process development supporting early and/ or late-stage development of biologics is highly desirable (cell therapy, gene therapy, vaccines, antibodies) Experience with Design of Experiment (DOE) approaches and application to process improvement Experience in technical transfer of processes to CDMOs Familiarity with FDA and EMA guidance documents relevant to gene and cell therapy is a plus
Obsidian Therapeutics is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases. Obsidian's programs apply our CytoDriveTM technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Our Opportunity… We're looking for a highly motivated scientist with a strong background in cell therapy and/or process development to help drive the development of multiple cell therapy products in our pipeline targeting cancer. As part of our Technical Development and Manufacturing department, you will be a vital part of a highly collaborative team working to achieve Obsidian's vision by translating innovative science into medical breakthroughs for patients. This is a unique opportunity in a well-funded early-stage company with blue-chip investors, field-leading advisors, and a highly experienced team. You will help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need. Located in the heart of Cambridge, we're proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. We offer competitive salary and benefits, and potential for employee ownership through stock options. You Will… Contribute your expertise to develop clinical/commercial manufacturing processes, cell therapy products, tech transfer to CDMOs, oversight of external manufacturing, and regulatory filings Drive the design and execution of experiments for development of the cGMP manufacturing process and associate process controls for clinical supply of cell therapy product (and related materials) meeting yield and quality targets Author and review technical and scientific documents including but not limited to study protocols and reports, validation documents, SOPs, and test methods Help build the team, and train and mentor team members on experiment design, data analysis with appropriate scientific rigor and proper documentation in lab notebooks Innovate solutions to address current technical challenges and evaluate/ incorporate next-generation process technologies Supply development materials (viral vector, cell product) to support research/nonclinical studies, analytical development, and CDMO tech transfer activities Lead and support key technology transfer document preparation, technology transfer & implementation of the process, and serve as the technical point of contact for the process development function in assigned projects Establish strong relationships and collaborate closely with internal stakeholders (research, quality, regulatory, project management) Represent process development in CMC sub-teams for assigned projects and support project activities including authoring of relevant CMC sections in regulatory documents You Bring… Core Qualifications Ph.D. and 3+ years of industry experience in a relevant discipline (chemical engineering, biomolecular engineering, biotechnology or relevant field), or MS plus 10 years relevant experience. Subject matter expertise in mammalian cell culture and related aspects such as cell metabolism/media optimization, engineering fundamentals on cell culture scaleup/down, cell biology/physiology Hands-on experience with product characterization methods relevant to cell therapy (e.g. flow cytometry) Highly collaborative working style, and ability to adapt in a fast-paced, rapidly developing environment Ability to work with minimal direction to meet objectives and timelines, adapting to changes and priorities in order to fulfill our mission Bonus Qualifications Prior experience with T-cells, NK cells, induced pluripotent stem cells (iPSC), or other primary cells is a plus. Demonstrated track record with process development supporting early and/or late-stage development of biologics (cell therapy, gene therapy, vaccines, antibodies…) Experience with and technology transfer to CDMOs and external manufacturing oversight Familiar with FDA and EMA guidance documents relevant to gene and cell therapy Experience authoring CMC sections of regulatory documents (IND/BLA) and engaging regulatory authorities Experience with Design of Experiment (DOE) approaches and application to process development Strong working knowledge of cGMP and quality systems requirements Prior experience in managing people and matrixed teams
03/23/2021
Full time
Obsidian Therapeutics is pioneering the development of controllable cell and gene therapies to deliver transformative outcomes for patients with intractable diseases. Obsidian's programs apply our CytoDriveTM technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Our Opportunity… We're looking for a highly motivated scientist with a strong background in cell therapy and/or process development to help drive the development of multiple cell therapy products in our pipeline targeting cancer. As part of our Technical Development and Manufacturing department, you will be a vital part of a highly collaborative team working to achieve Obsidian's vision by translating innovative science into medical breakthroughs for patients. This is a unique opportunity in a well-funded early-stage company with blue-chip investors, field-leading advisors, and a highly experienced team. You will help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need. Located in the heart of Cambridge, we're proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. We offer competitive salary and benefits, and potential for employee ownership through stock options. You Will… Contribute your expertise to develop clinical/commercial manufacturing processes, cell therapy products, tech transfer to CDMOs, oversight of external manufacturing, and regulatory filings Drive the design and execution of experiments for development of the cGMP manufacturing process and associate process controls for clinical supply of cell therapy product (and related materials) meeting yield and quality targets Author and review technical and scientific documents including but not limited to study protocols and reports, validation documents, SOPs, and test methods Help build the team, and train and mentor team members on experiment design, data analysis with appropriate scientific rigor and proper documentation in lab notebooks Innovate solutions to address current technical challenges and evaluate/ incorporate next-generation process technologies Supply development materials (viral vector, cell product) to support research/nonclinical studies, analytical development, and CDMO tech transfer activities Lead and support key technology transfer document preparation, technology transfer & implementation of the process, and serve as the technical point of contact for the process development function in assigned projects Establish strong relationships and collaborate closely with internal stakeholders (research, quality, regulatory, project management) Represent process development in CMC sub-teams for assigned projects and support project activities including authoring of relevant CMC sections in regulatory documents You Bring… Core Qualifications Ph.D. and 3+ years of industry experience in a relevant discipline (chemical engineering, biomolecular engineering, biotechnology or relevant field), or MS plus 10 years relevant experience. Subject matter expertise in mammalian cell culture and related aspects such as cell metabolism/media optimization, engineering fundamentals on cell culture scaleup/down, cell biology/physiology Hands-on experience with product characterization methods relevant to cell therapy (e.g. flow cytometry) Highly collaborative working style, and ability to adapt in a fast-paced, rapidly developing environment Ability to work with minimal direction to meet objectives and timelines, adapting to changes and priorities in order to fulfill our mission Bonus Qualifications Prior experience with T-cells, NK cells, induced pluripotent stem cells (iPSC), or other primary cells is a plus. Demonstrated track record with process development supporting early and/or late-stage development of biologics (cell therapy, gene therapy, vaccines, antibodies…) Experience with and technology transfer to CDMOs and external manufacturing oversight Familiar with FDA and EMA guidance documents relevant to gene and cell therapy Experience authoring CMC sections of regulatory documents (IND/BLA) and engaging regulatory authorities Experience with Design of Experiment (DOE) approaches and application to process development Strong working knowledge of cGMP and quality systems requirements Prior experience in managing people and matrixed teams