Scientist II, Protein Engineer, Global Biologics

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Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Scientist II, Protein Engineer, Global Biologics in our Cambridge, MA office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

POSITION OBJECTIVES:

Takeda is committed to the long term strategy and vision to translate science into life- changing medicines that make critical differences for our patients around the world. The Global Biologics team within R&D consists of approx. 85 scientists across two US sites (Cambridge MA and San Diego), and aims to discover novel therapeutic large molecule biologics serving our four main therapeutic areas Oncology, Gastroenterology, Neuroscience and Rare Disease.

We are excited to pursue the search for a Scientist II to join our Biotherapeutic Engineering team, a group within Takedas Global Biologics Department. The new hire will join a team of motivated and enthusiastic scientists in the Cambridge MA location. This role will be responsible for implementing workflows tailored towards protein engineering, primarily enzymes. The successful candidate will be directly involved in protein engineering from design and build of mutant libraries through to high throughput screening and characterization of candidates. The candidate should also be flexible, leading different aspects throughout the protein engineering workflow, have the ability to work independently, should have excellent communication skills working with team members to ensure smooth co-ordination of activities.

POSITION ACCOUNTABILITIES:

• Design optimization libraries using in silico tools, followed by manipulation of the plasmid based DNA libraries.
• Utilize display based systems (yeast, phage) and screening to identify improved mutant proteins.
• Evaluate and analyze protein sequence, mutational libraries using state of the art sequence analysis software .
• Plan and execute appropriate in vitro experiments to optimize and characterize libraries.
• Co-ordinate with team members to perform high throughput plate-based production and purification of protein from yeast, mammalian cells and/or bacteria .
• Help to guide and implement workflows and infrastructure tailored to protein or enzyme engineering .
• Maintain, propagate and transform yeast, mammalian and/or bacterial cultures .
• Basic characterization of purified proteins using standard techniques, such as SDS- PAGE .
• Manage and run automation, in addition to manual steps throughout the process .
• Demonstrate high organization capabilities to ensure excellent tracking of ongoing and incoming targets and projects .
• Work closely with project team leads to develop project strategies and to coordinate work within Global biologics .
• Upload and track data into data management systems and maintain detailed electronic notebook .
• Work with a fast pace to meet program and team needs.
• Track record of demonstrating analytical skills, bench skills and problem-solving skills.

DIMENSIONS AND ASPECTS:

Technical/ functional (Line Expertise):

• Excellent knowledge of protein engineering and mutagenesis approaches .
• Demonstrated experience in protein production in mammalian or prokaryotic systems .
• Experience with high throughput workflows and automation .

Leadership:

• Identifies, plans and executes novel scientific projects and may manage the work of others a direct or matrixed structure .

Decision-making and Autonomy:

• Independently manages workload and expectations .
• Scientifically independent .
• May influence decision making within the department .
• Troubleshoot where necessary, and persevere to ensure that workflows are operating maximally .

Interaction:

• Effective oral and written communication as well as strong interpersonal skills required.

Innovation:

• Receives high level instructions on all work, determines methods on new assignments, works closely with manager, may manage junior staff .

EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:

• PhD (2+y experience), or MS (8+ years experience) in Molecular Biology, Protein Engineering, Biochemistry or similar .
• Experience with protein engineering and standard mutagenesis approaches is preferred .
• Highly skilled in standard molecular biology techniques and cell culture techniques (yeast, bacterial, mammalian) .
• Experience in protein production and purification is preferred.
• Experience working with and troubleshooting automation and liquid handling is a plus.
• Effective resource and time management is essential.
• Effective oral and written communication as well as strong interpersonal skills required .
• Hard working, enthusiastic, self-motivated, team oriented with a strong collaborative spirit .

WHAT TAKEDA CAN OFFER YOU:

• 401(k) with company match and Annual Retirement Contribution Plan
• Tuition reimbursement Company match of charitable contributions
• Health & Wellness programs including onsite flu shots and health screenings
• Generous time off for vacation and the option to purchase additional vacation days
• Community Outreach Programs

Empowering Our People to Shine

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