The Supply Chain Intern will support the sourcing, analytical, and planning pillars of the Supply Chain Management team by helping to design and implement an electronic inventory management system and helping to identify optimization opportunities in our clinical trial logistics strategy. In addition, this role will support development of supply agreements, contract management, RFP (Request for Proposal) analysis, supply chain metrics, and other day-to-day supply chain activities. This position is a full-time internship, working 40 hours per week for approximately 12 weeks in the summer. Essential Duties and Responsibilities Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document. Support design and implementation of an electronic Inventory management system Analyze historical shipment data to Identify optimization opportunities for clinical shipments, recommend overages required per shipment, identify optimal number of shipments to plan for a Ph. 1 and Ph. 2a study, and recommend improvements to the current design of clinical logistics Support RFP (Request for Proposal) process by leveraging cost modeling or purchase price analysis Support the development of supply agreement contracts or master service agreements for critical suppliers, and support contract renewals Develop recommendations on which metrics we should pursue and how to obtain the data Develop analytical models to support maintaining recommended metrics Conduct market research to support identification of dual sources for critical raw materials Perform spend analytics to identify areas of focus for strategic sourcing and cost savings Qualifications The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully. Currently pursuing an MBA or graduate degree in Industrial Engineering or other graduate level degree related to the Biotech-pharma or gene therapy industries with an interest in Supply Chain Prior experience or interest within a sourcing, materials management, planning, logistics or supply chain related function; industry experience preferred but not required Skilled in Data analytics leveraging advanced excel analytics and/or Tableau type software with the ability to develop data dashboards to translate deep data sets into meaningful metrics and visual representations Ability to develop and augment data sets via aggregation of multiple disparate data sources. Location This is a primarily office-based position associated with the main headquarters in downtown Durham, NC. For the time being, this role will be able to function remotely in accordance with company safety guidelines throughout the duration of the pandemic but is subject to change as needed. Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS genome editing platform. This isnt just a statement supporting the products that were developing its a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.
01/28/2021
Full time
The Supply Chain Intern will support the sourcing, analytical, and planning pillars of the Supply Chain Management team by helping to design and implement an electronic inventory management system and helping to identify optimization opportunities in our clinical trial logistics strategy. In addition, this role will support development of supply agreements, contract management, RFP (Request for Proposal) analysis, supply chain metrics, and other day-to-day supply chain activities. This position is a full-time internship, working 40 hours per week for approximately 12 weeks in the summer. Essential Duties and Responsibilities Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document. Support design and implementation of an electronic Inventory management system Analyze historical shipment data to Identify optimization opportunities for clinical shipments, recommend overages required per shipment, identify optimal number of shipments to plan for a Ph. 1 and Ph. 2a study, and recommend improvements to the current design of clinical logistics Support RFP (Request for Proposal) process by leveraging cost modeling or purchase price analysis Support the development of supply agreement contracts or master service agreements for critical suppliers, and support contract renewals Develop recommendations on which metrics we should pursue and how to obtain the data Develop analytical models to support maintaining recommended metrics Conduct market research to support identification of dual sources for critical raw materials Perform spend analytics to identify areas of focus for strategic sourcing and cost savings Qualifications The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully. Currently pursuing an MBA or graduate degree in Industrial Engineering or other graduate level degree related to the Biotech-pharma or gene therapy industries with an interest in Supply Chain Prior experience or interest within a sourcing, materials management, planning, logistics or supply chain related function; industry experience preferred but not required Skilled in Data analytics leveraging advanced excel analytics and/or Tableau type software with the ability to develop data dashboards to translate deep data sets into meaningful metrics and visual representations Ability to develop and augment data sets via aggregation of multiple disparate data sources. Location This is a primarily office-based position associated with the main headquarters in downtown Durham, NC. For the time being, this role will be able to function remotely in accordance with company safety guidelines throughout the duration of the pandemic but is subject to change as needed. Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS genome editing platform. This isnt just a statement supporting the products that were developing its a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.
If you are interested in a career opportunity with Precision BioSciences and there is not a current role that meets your experience and skills, you can apply through our General Application. If your qualifications match our needs, you will be contacted by a member of our Talent Acquisition Team. Warm Regards, Precision BioSciences
01/26/2021
Full time
If you are interested in a career opportunity with Precision BioSciences and there is not a current role that meets your experience and skills, you can apply through our General Application. If your qualifications match our needs, you will be contacted by a member of our Talent Acquisition Team. Warm Regards, Precision BioSciences
The Director, Head of Analytical Sciences and Technology (AS&T) will be part of the CMC Technical Operations leadership team and a key member of the wider CMC organization. The incumbent will work cross functionally to support the successful development and manufacture of Precision BioSciences Cell and Gene Therapy Products. This is a highly visible role within Precision BioSciences as well as with external partners and will be influential in the strategic and tactical leadership of the Technical Operations organization. The Director, Head of AS&T will be responsible for leading the AS&T function in the development and execution of analytical testing strategies to support the manufacture of allogeneic CAR T and AAV gene therapy products. Responsibilities include oversight of analytical testing at external contract laboratories and contract manufacturers, development and implementation of stability strategies for the allogeneic CAR-T, AAV, and mRNA platforms, management of the critical reagent program, and implementation of data analytics approaches for tracking and trending product quality and method performance. The successful candidate will also provide leadership in defining the analytical strategy and development of plans to support late-stage and commercial readiness. The Head of AS&T will work cross-functionally with Quality Control, Quality Assurance, Regulatory Affairs, and Analytical Development functions to establish state of the art and robust analytical approaches that comply with regulatory expectations and relevant quality guidelines. This role will also work closely with the Head of MS&T and the Head of Manufacturing to support implementation of appropriate analytical control strategies for new programs and optimized manufacturing processes. The Head of AS&T will also lead/support establishment of specifications, product comparability studies, and technical investigations. Additionally, the success candidate will provide technical and strategic input and support for the preparation of regulatory submissions and health authority interactions. Essential Duties and Responsibilities Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document. Provide oversight of external testing laboratory activities including management of analytical testing, data review, troubleshooting, method improvement, generation of reports, and technical support; support external technology transfers as needed Develop and implement a GMP-compliant Stability Program for Precision BioSciences Cell and Gene Therapy products, and all associated key process intermediates (cell banks, plasmids, mRNA, AAV) Support or lead the development of analytical control strategies for CAR T and AAV products, and key process intermediates Implement and manage an analytical data tracking and trending program to monitor product quality, stability, and method performance Develop and maintain an effective program to manage Critical Reagents and Reference Standards to ensure compliant and consistent product quality testing Work cross-functionally to define a stage-appropriate control strategy for Infectious Disease Testing (IDT) for allogeneic CAR T products Support development of phase-appropriate method validation approaches for release and characterization testing Support or lead the Specification Team to establish, review, update and maintain product specifications for CAR T and AAV products as well as for key process intermediates Author/Review study protocols, reports, SOPs, investigations, change controls, and method development/qualification reports Author/Review regulatory submissions (IND, briefing packages, responses to questions) and provide strategic and technical support for interactions with health authorities Develop short- and long-term strategic plans for the AS&T function that are aligned with Precisions plans to support development and commercialization of its products Set strategic objectives, provide clear direction, and manage execution for the AS&T function Responsible for organizational design and staffing decisions for the AS&T function. Recruit, retain, train and develop team members Build and sustain employee engagement by creating a culture of efficient execution and an environment in which individuals and teams can excel and continuously improve Interface with external partners and internal QA and QC groups to support review of data, lab investigations, change controls, etc. Remain current with regulatory and industry requirements relevant to analytical testing, specifications, and stability programs for cell and gene therapy products to support clinical development and commercial registration Qualifications The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully. Required: PhD in Biochemistry, Biology, or related field and 10+ years of experience in the biotechnology/pharmaceutical industry with increasing responsibility in analytical development or quality management, or equivalent combination of education and experience 7+ years of analytical management experience to support development of biological products Deep expertise in assay development, method qualification/validation, quality requirements, and regulatory expectations for testing of biological and cell & gene therapy products Experience in authoring regulatory submissions (INDs, briefing packages, BLAs) and face-to-face interactions with regulatory agencies (FDA) Expertise in leading activities to support technical investigations, deviations and change controls Demonstrated experience managing analytical testing at external contract organizations Preferred: Experience in Quality Control, Analytical Sciences and Technology, or Analytical Development in a biopharmaceutical or cell and gene therapy company Experience with gene/cell therapy products; experience with late-stage and commercialization programs strongly preferred Excellent planning, organization, prioritization, and management skills to direct the work of others on assigned projects, including internal teams and external collaborators Demonstrated ability to create and foster effective teamwork, build relationships, motivate others, work in a matrix organization, and collaborate at all organizational levels Results oriented, with a sense of urgency; strong initiative, accountability, and willingness to take ownership and drive projects to completion Comfortable with rolling up the sleeves and executing the work needed to support the success of projects in a small company environment Strong critical thinking and problem-solving skills Excellent written and verbal communication skills Experience in good documentation practices, data archiving, and statistical approaches to support data trending and stability analyses Travel Requirements This position requires some travel (10%) Location This is a primarily office-based position associated with the main headquarters in downtown Durham, NC. For the time being, this role will be able to function remotely in accordance with company safety guidelines throughout the duration of the pandemic but is subject to change as needed. Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS genome editing platform. This isnt just a statement supporting the products that were developing its a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.
01/23/2021
Full time
The Director, Head of Analytical Sciences and Technology (AS&T) will be part of the CMC Technical Operations leadership team and a key member of the wider CMC organization. The incumbent will work cross functionally to support the successful development and manufacture of Precision BioSciences Cell and Gene Therapy Products. This is a highly visible role within Precision BioSciences as well as with external partners and will be influential in the strategic and tactical leadership of the Technical Operations organization. The Director, Head of AS&T will be responsible for leading the AS&T function in the development and execution of analytical testing strategies to support the manufacture of allogeneic CAR T and AAV gene therapy products. Responsibilities include oversight of analytical testing at external contract laboratories and contract manufacturers, development and implementation of stability strategies for the allogeneic CAR-T, AAV, and mRNA platforms, management of the critical reagent program, and implementation of data analytics approaches for tracking and trending product quality and method performance. The successful candidate will also provide leadership in defining the analytical strategy and development of plans to support late-stage and commercial readiness. The Head of AS&T will work cross-functionally with Quality Control, Quality Assurance, Regulatory Affairs, and Analytical Development functions to establish state of the art and robust analytical approaches that comply with regulatory expectations and relevant quality guidelines. This role will also work closely with the Head of MS&T and the Head of Manufacturing to support implementation of appropriate analytical control strategies for new programs and optimized manufacturing processes. The Head of AS&T will also lead/support establishment of specifications, product comparability studies, and technical investigations. Additionally, the success candidate will provide technical and strategic input and support for the preparation of regulatory submissions and health authority interactions. Essential Duties and Responsibilities Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document. Provide oversight of external testing laboratory activities including management of analytical testing, data review, troubleshooting, method improvement, generation of reports, and technical support; support external technology transfers as needed Develop and implement a GMP-compliant Stability Program for Precision BioSciences Cell and Gene Therapy products, and all associated key process intermediates (cell banks, plasmids, mRNA, AAV) Support or lead the development of analytical control strategies for CAR T and AAV products, and key process intermediates Implement and manage an analytical data tracking and trending program to monitor product quality, stability, and method performance Develop and maintain an effective program to manage Critical Reagents and Reference Standards to ensure compliant and consistent product quality testing Work cross-functionally to define a stage-appropriate control strategy for Infectious Disease Testing (IDT) for allogeneic CAR T products Support development of phase-appropriate method validation approaches for release and characterization testing Support or lead the Specification Team to establish, review, update and maintain product specifications for CAR T and AAV products as well as for key process intermediates Author/Review study protocols, reports, SOPs, investigations, change controls, and method development/qualification reports Author/Review regulatory submissions (IND, briefing packages, responses to questions) and provide strategic and technical support for interactions with health authorities Develop short- and long-term strategic plans for the AS&T function that are aligned with Precisions plans to support development and commercialization of its products Set strategic objectives, provide clear direction, and manage execution for the AS&T function Responsible for organizational design and staffing decisions for the AS&T function. Recruit, retain, train and develop team members Build and sustain employee engagement by creating a culture of efficient execution and an environment in which individuals and teams can excel and continuously improve Interface with external partners and internal QA and QC groups to support review of data, lab investigations, change controls, etc. Remain current with regulatory and industry requirements relevant to analytical testing, specifications, and stability programs for cell and gene therapy products to support clinical development and commercial registration Qualifications The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully. Required: PhD in Biochemistry, Biology, or related field and 10+ years of experience in the biotechnology/pharmaceutical industry with increasing responsibility in analytical development or quality management, or equivalent combination of education and experience 7+ years of analytical management experience to support development of biological products Deep expertise in assay development, method qualification/validation, quality requirements, and regulatory expectations for testing of biological and cell & gene therapy products Experience in authoring regulatory submissions (INDs, briefing packages, BLAs) and face-to-face interactions with regulatory agencies (FDA) Expertise in leading activities to support technical investigations, deviations and change controls Demonstrated experience managing analytical testing at external contract organizations Preferred: Experience in Quality Control, Analytical Sciences and Technology, or Analytical Development in a biopharmaceutical or cell and gene therapy company Experience with gene/cell therapy products; experience with late-stage and commercialization programs strongly preferred Excellent planning, organization, prioritization, and management skills to direct the work of others on assigned projects, including internal teams and external collaborators Demonstrated ability to create and foster effective teamwork, build relationships, motivate others, work in a matrix organization, and collaborate at all organizational levels Results oriented, with a sense of urgency; strong initiative, accountability, and willingness to take ownership and drive projects to completion Comfortable with rolling up the sleeves and executing the work needed to support the success of projects in a small company environment Strong critical thinking and problem-solving skills Excellent written and verbal communication skills Experience in good documentation practices, data archiving, and statistical approaches to support data trending and stability analyses Travel Requirements This position requires some travel (10%) Location This is a primarily office-based position associated with the main headquarters in downtown Durham, NC. For the time being, this role will be able to function remotely in accordance with company safety guidelines throughout the duration of the pandemic but is subject to change as needed. Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS genome editing platform. This isnt just a statement supporting the products that were developing its a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.
The Research Associate II or III will work within the Animal Studies team to carry out histology studies that support a diverse range of research efforts in accordance with Precision BioSciences goals. The ideal candidate should have confidence with various histological techniques to carry out histochemical, immunohistochemical, and in situ studies for advancing clinical trials within the cell and gene therapy field. Essential Duties and Responsibilities Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document. Perform laboratory experiments including sample preparation and data collection using established protocols Prepare sections of tissue for microscopic examination, using techniques to dissect tissue; embed and orient in paraffin block, cut thin sections of tissue, mount onto glass slides, and stain for features of interest Operate computerized instrumentation for tissue dehydration, section clearing, impregnation with paraffin, cutting tissue sections, and staining of slides Perform recuts and additional stains, including immunohistochemistry and other specialized stains as needed Carry out studies involving histochemical, immunohistochemical, and in situ experiments Assist with assay development and optimization Perform imaging analysis Assist, when needed, with PBS and formalin perfusion, fixation, tissue harvesting, and other tasks as deemed necessary May label containers, cassettes and/or slides and affixes coverslips to slides Maintain laboratory equipment and tracks all routine maintenance and quality controls performed Dispose of hazardous chemical wastes per regulatory guidelines Review journals, abstracts and scientific literature to keep up with new developments, procedures, and techniques Qualifications The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully. Education/ Experience: Successful candidate should have a BS in life sciences and 2+ years of relevant histology experience; or equivalent combination of education and experience Required: Ability to work with hazardous chemicals and knowledge of safety requirements to provide instructions and recognize and correct hazardous conditions Demonstrated skill in performing a full range of histology applications and operating a variety of laboratory instrumentation Experience with In Situ Hybridization (ISH) and Immunohistochemistry (IHC) techniques Ability to establish and maintain positive relationships with employees, vendors and external agencies Ability to identify and resolve problems as well as communicate clearly and concisely The ability to work successfully both independently and in a collaborative environment Ability to handle multiple tasks and prioritize effectively Preferred: Cell/gene therapy experience is a plus Location This is a laboratory-based position located out of Precision BioSciences main campus in Durham, NC Travel Requirements Minimal local travel may be expected for this position. If needed, the Research Associate II-III will be required, on occasion, to travel locally between Precision BioSciences main campus and animal facility in Durham, NC Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS genome editing platform. This isnt just a statement supporting the products that were developing its a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.
01/20/2021
Full time
The Research Associate II or III will work within the Animal Studies team to carry out histology studies that support a diverse range of research efforts in accordance with Precision BioSciences goals. The ideal candidate should have confidence with various histological techniques to carry out histochemical, immunohistochemical, and in situ studies for advancing clinical trials within the cell and gene therapy field. Essential Duties and Responsibilities Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document. Perform laboratory experiments including sample preparation and data collection using established protocols Prepare sections of tissue for microscopic examination, using techniques to dissect tissue; embed and orient in paraffin block, cut thin sections of tissue, mount onto glass slides, and stain for features of interest Operate computerized instrumentation for tissue dehydration, section clearing, impregnation with paraffin, cutting tissue sections, and staining of slides Perform recuts and additional stains, including immunohistochemistry and other specialized stains as needed Carry out studies involving histochemical, immunohistochemical, and in situ experiments Assist with assay development and optimization Perform imaging analysis Assist, when needed, with PBS and formalin perfusion, fixation, tissue harvesting, and other tasks as deemed necessary May label containers, cassettes and/or slides and affixes coverslips to slides Maintain laboratory equipment and tracks all routine maintenance and quality controls performed Dispose of hazardous chemical wastes per regulatory guidelines Review journals, abstracts and scientific literature to keep up with new developments, procedures, and techniques Qualifications The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully. Education/ Experience: Successful candidate should have a BS in life sciences and 2+ years of relevant histology experience; or equivalent combination of education and experience Required: Ability to work with hazardous chemicals and knowledge of safety requirements to provide instructions and recognize and correct hazardous conditions Demonstrated skill in performing a full range of histology applications and operating a variety of laboratory instrumentation Experience with In Situ Hybridization (ISH) and Immunohistochemistry (IHC) techniques Ability to establish and maintain positive relationships with employees, vendors and external agencies Ability to identify and resolve problems as well as communicate clearly and concisely The ability to work successfully both independently and in a collaborative environment Ability to handle multiple tasks and prioritize effectively Preferred: Cell/gene therapy experience is a plus Location This is a laboratory-based position located out of Precision BioSciences main campus in Durham, NC Travel Requirements Minimal local travel may be expected for this position. If needed, the Research Associate II-III will be required, on occasion, to travel locally between Precision BioSciences main campus and animal facility in Durham, NC Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS genome editing platform. This isnt just a statement supporting the products that were developing its a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.
The Research Associate I will be responsible for the execution of cell biology tasks such as maintenance of mammalian cell lines, cell transfection and transduction, stable cell line generation, flow cytometry analysis, development of cell-based assays, lentivirus production . The Research Associate I will follow direction for execution and troubleshooting of experiments in order to produce results by expected deadlines. The position will also involve independent data analysis, proper documentation preparation, and report generation for the supervisor as well as for the rest of the group. Essential Duties and Responsibilities Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document. Maintenance of cell cultures Transient and stable transfections Lentivirus production and cell transduction Recombinant protein expression in mammalian cells Flow cytometry analysis and cell sorting Collaborate with Scientists on new and established cell-based assay development and high throughput screening Make reagents as needed Assist the team with other projects as needed Qualifications The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully. Education/ Experience Required: BS in Biological Sciences, with at least 1 year of laboratory experience; or equivalent combination of education and experience Hands-on experience with basic cell biology methods, such as maintenance of mammalian cell cultures and transient/stable transfections Familiarity with flow cytometry Knowledge of basic Microsoft Office software, such as Word, PowerPoint, Excel Ability to work independently and in team-environment Strong communication skills, including written and verbal reporting to supervisor, team, and company Preferred: Knowledge of recombinant protein expression in mammalian cells Experience with lentivirus/retrovirus production (or AAV production) Experience with flow cytometry analysis software (i.e. FlowJo) Location This is a laboratory-based position located at the main headquarters in downtown Durham, NC Travel Requirements Little to no travel is required for this position Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS genome editing platform. This isnt just a statement supporting the products that were developing its a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.
01/17/2021
Full time
The Research Associate I will be responsible for the execution of cell biology tasks such as maintenance of mammalian cell lines, cell transfection and transduction, stable cell line generation, flow cytometry analysis, development of cell-based assays, lentivirus production . The Research Associate I will follow direction for execution and troubleshooting of experiments in order to produce results by expected deadlines. The position will also involve independent data analysis, proper documentation preparation, and report generation for the supervisor as well as for the rest of the group. Essential Duties and Responsibilities Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document. Maintenance of cell cultures Transient and stable transfections Lentivirus production and cell transduction Recombinant protein expression in mammalian cells Flow cytometry analysis and cell sorting Collaborate with Scientists on new and established cell-based assay development and high throughput screening Make reagents as needed Assist the team with other projects as needed Qualifications The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully. Education/ Experience Required: BS in Biological Sciences, with at least 1 year of laboratory experience; or equivalent combination of education and experience Hands-on experience with basic cell biology methods, such as maintenance of mammalian cell cultures and transient/stable transfections Familiarity with flow cytometry Knowledge of basic Microsoft Office software, such as Word, PowerPoint, Excel Ability to work independently and in team-environment Strong communication skills, including written and verbal reporting to supervisor, team, and company Preferred: Knowledge of recombinant protein expression in mammalian cells Experience with lentivirus/retrovirus production (or AAV production) Experience with flow cytometry analysis software (i.e. FlowJo) Location This is a laboratory-based position located at the main headquarters in downtown Durham, NC Travel Requirements Little to no travel is required for this position Precision BioSciences, Inc. (Nasdaq: DTIL), is a clinical stage biotechnology company dedicated to improving life (DTIL) with its novel and proprietary ARCUS genome editing platform. This isnt just a statement supporting the products that were developing its a statement that speaks to our collective desire to do our part in improving the lives of those around us. ARCUS is a highly specific and versatile genome editing platform designed with therapeutic safety, delivery, and control in mind. Using ARCUS, Precision is developing allogeneic CAR T and in vivo gene correction therapies for cancer and genetic diseases. Our team includes pioneers in genome editing, leaders in business, and a full staff of talented and committed people who are excited to be a part of medical and scientific breakthroughs. For additional information, please visit www. precisionbiosciences.com Precision BioSciences actively fosters an inclusive environment to ensure we attract and retain the best talent; we value diversity of life experiences and perspectives; and we encourage innovation in pursuit of our mission. We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.