Gladstone Institutes

Category:Administration Lab/Area:GIV AdministrationDescription: The Gladstone Institutes is an independent, not-for-profit research institution. Its mission is to improve the health and well-being of all people through medical research and education in neuroscience, cardiovascular biology, immunology, and stem cell biology. Home to notable leaders in science and biomedicine, Gladstone comprises four institutes as well as various centers and programs. All of its approximately 500 members are aligned in their mission to carry out or support science that overcomes disease. Located in an award-winning building at the Mission Bay Campus, Gladstone offers a competitive salary and benefits program. It provides an ideal environment for those seeking to maximize and fully leverage their potential. Consider Gladstone and make a difference in human health. The Weinberger Lab is seeking an administrative assistant to join our team. Leor Weinberger's lab studies fundamental viral biology to develop new antiviral medicines against viruses such as SARS-CoV-2, herpesviruses, and HIV. His lab developed and pioneered a novel antiviral concept for resource-limited settings such as sub-Saharan Africa (see his TED talk ). The group also develops novel therapies for herpesviruses such as cytomegalovirus, a leading cause of transplant failures and birth defects. This person will work closely with Dr. Leor Weinberger, the lab's PI, but will require the ability to work well independently, and manage a wide variety of tasks. The successful candidate will be passionate about precision in their work and be an exceptionally effective communicator. This job may be a great fit for an administrative professional or project coordinator who is looking for experience with project management, or working in a scientific environment. Responsibilities include: Preparing, formatting, and proofreading scientific manuscripts, research grants, and grant reports Delegating project responsibilities to a team Managing emails and responding professionally in a timely manner to research colleagues and government sponsors Organizing calendar and scheduling meetings for PI Coordinating travel arrangements and planning itineraries Monitoring financial expenses, processing and tracking payments, maintaining financial records Being the lab "social coordinator": planning team events, coordinating new member arrivals to and departures from the lab Maintaining understanding of individuals' and teams' roles at Gladstone to best refer questions and contacts This person will be expected to juggle a wide variety of tasks; the ideal candidate must be willing to learn and take on tasks somewhat unconventional for academic environments (e.g., interfacing with biotech startups/spinouts) to assist the PI at a very pivotal time for the lab's research. Preferred qualifications: 2-5 years previous administrative work experience Associate or Bachelor's Degree or equivalent life and work experience Skilled with Google Suite, Microsoft Office, Zoom, and DropBox Scientific experience, either professionally or educationally, with an ability to satisfactorily write and read scientific language Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category:Administration Lab/Area:GrantsDescription: The Gladstone Institutes is seeking an experienced Pre-Award Grants Administrator to join its Grants and Contracts Department on a temporary, full-time basis through December 2021. This position is fully remote, working West Coast business hours. This position will provide direct support to Gladstone's principal investigators in all aspects of pre-award research administration. From day one, the successful candidate will be a trusted partner to Gladstone scientists throughout the proposal development process, and will work cross-functionally with scientific and administrative teams to provide excellent service and generate high-quality deliverables. They will be comfortable managing competing deadlines and working with diverse constituents in a fast-paced research environment. The successful candidate will: Own the pre-award process from idea to award, working in close partnership with principal investigators and staff scientists to move proposals through the pipeline. Track application deadlines and manage time accordingly. Ensure proposals conform to sponsor regulations and requirements. Develop budgets and administrative documentation for outgoing proposals. Ensure compliance with internal review and approval processes. Submit research proposals to sponsors. Negotiate acceptable award terms. Review awards for compliance and audit issues. Assist with identifying potential funding sources. Process non-competing continuations, progress reports, supplements, subaward requests, research agreements and all other award and agreement amendments. Coordinate Just-In-Time submissions for probable awards. Complete award setup in the accounting system. Perform data entry in proposal and award tracking system. Generate Pre-Award Reports for the Grants Department. Qualifications: Bachelor's degree and/or equivalent experience. 1-3 years of NIH grants management experience. Experience with other sponsors who support biomedical research (DOD/USAMRAA, NSF, CIRM) a plus. Excellent attention to detail, outstanding customer service and impeccable communication skills are required for this position. Demonstrated pre-award management experience, including proposal development. The ability to manage a high volume of work and competing deadlines in a fast-paced, deadline-driven work environment. Comfort working remotely and using tools to facilitate remote work, e.g., Zoom, Slack. Effective analytical and creative problem solving skills. Comfort with business systems that hold financial and administrative information, such Workday. Proficiency with Microsoft Word and Excel, with particular regard to Excel formulas. Experience using electronic pre- and post-award systems such as Grants.gov Workspace, NIH ASSIST, and NSF Fastlane/Research.gov. Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category:Administration Lab/Area:GIDB AdministrationDescription: Administrative Assistant - GIDB Overview: The Gladstone Institutes is an independent, not-for-profit research institution affiliated with the University of California San Francisco (UCSF), contributing to the health and well-being of all people through research, technology development, education, and outreach in human biology and diseases of the heart, brain, and immune system. Gladstone is composed of 400 employees who receive exceptional benefits. We are located in an award-winning building adjacent to UCSF's Mission Bay Campus. Gladstone has consistently ranked as one of the top places to work in academia in the United States. Responsibilities: The Gladstone Institutes is recruiting a well-organized, highly skilled and motivated Administrative Assistant to provide comprehensive administrative support for two investigators and their labs at the Gladstone Institute of Data Science & Biotechnology. Key duties include handling routine correspondence and communications on behalf of the investigators, managing calendars and schedules, regular updating and formatting of supporting documents for grant applications, making travel arrangements, coordinating seminars and special events, and managing all office activities. The ideal candidate will be able to pro-actively anticipate needs, prioritize tasks, and use independent judgment to trouble-shoot and solve problems. Essential Functions and Duties: Word process, format, organize, proofread and correct correspondence, manuscripts, bibliographies, grants, fellowship applications and other documents, as required. Accurately read and follow grant and fellowship application procedures and format. Establish and maintain computerized templates/forms and up to date standard sections for grant applications (e.g., Resources and Environment; Biographical Sketch; Other Support). Asist with coordinating travel arrangements and preparing detailed itineraries. Maintain accurate travel records, process reimbursement requests, and track as needed. Maintain investigators' calendars. Schedule meetings and appointments including pro-actively resolving schedule conflicts and arranging space, refreshments, and transportation, as appropriate. Assist with coordinating institute seminars and special events, including visitor's travel arrangements and agenda, catering, venue reservations, etc. Facilitate communication with other administrative offices such as Accounting, Grants, Human Resources, Philanthropy, IT, Executive Office and Facilities/Operations. Function as external liaison, as appropriate with other universities, research institutes, and government funding offices. Provide department support to postdoctoral scholars and graduate students. Administer purchase order functions. Maintain accurate records and efficient filing system for easy access to key information. Perform other duties as assigned. Qualifications: 4+ years relevant experience and a high school diploma, 2+ years relevant experience and AA/AS or BA/BS Experience with complex calendar management. Demonstrated ability to follow detailed directions with accuracy. Ability to multi-task and prioritize. Excellent written and verbal communication skills, including grammar, spelling, and editing. Strong interpersonal skills, ability to communicate in a professional manner with tact and discretion, and ability to work well independently and collaboratively. Highly proficient in all aspects of general administrative support. Interview process will include tests for formatting, proofreading, and drafting correspondence. Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category:Administration Lab/Area:FacilitiesDescription: We are currently recruiting for a Building Engineer III to join our team. Perform engineering tasks associated with preventive and corrective maintenance of building equipment and building systems. The person in this position will gain thorough knowledge of all building systems, and building management system, and how they integrate, helping to ensure that these systems perform their intended function. Respond to, and perform Facilities Queue requests in a timely and efficient manner. Work with the Facilities Team to ensure a safe working environment for all Gladstone personnel, and help improve overall energy efficiency of building. Provide emergency response as needed, and serve in On Call capacity a minimum of one week per month. The successful candidate, in addition to have strong engineering skills and aptitude, will have some supervisorial and/or managerial experience, with aspirations of being Chief Engineer. Education/Skills Experience Required: High School Diploma required. Completion of Technical and/or Trade Courses desired. 5+ years of hands-on experience. Advanced ability to troubleshoot and perform corrective maintenance on buildindg equipment. Experience working with HVAC, plumbing, and electrical systems is required. Carpentry and/or painting skills desired. Experience with Computerized Maintenance Management Systems, CMMS, desired. Experience with Building Automation Systems is required, and experience with Siemens automated systems, in particular, would be a plus. Knowledge of energy efficient measures for equipment operation. Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category: Science Lab/Area: Conklin Lab Description: Research Associate position in the Conklin laboratory at the Gladstone Institutes at Mission Bay (see ). Project on human therapeutic editing in close collaboration with the Innovative Genomics Institute. Projects focused on the basic mechanism of DNA repair, DNA-excision with motor neurons as model systems. Strong communication skills, with a background in molecular biology and cell culture preferred. Applicants intending on progressing to graduate school are encouraged to apply. A college degree (preferred) and laboratory experience required. Salary competitive and commensurate with experience. Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category: Science Lab/Area: Jain Lab Description: The Jain Lab ( ) at the Gladstone Institutes is looking for a research associate to begin working summer 2021. The scientific goal is to study oxygen metabolism and develop hypoxia/hyperoxia as a therapy for age-associated disorders. This position will require a combination of wet lab molecular biology/biochemistry experiments, as well as animal work. Applicant will be expected to perform a range of experimental techniques (cloning, western blots, protein biochemistry, tissue culture, microscopy, etc.) as well as animal husbandry (maintaining mouse colonies, designing breeding schemes, keeping daily record of body weights/survival/activity, behavioral studies, basic dissections, etc.). They will also be responsible for lab administrative responsibilities, such as maintaining and organizing lab inventory and interacting with buyers/sales reps. Applicant should be able to perform basic quantitative tasks (e.g. dilutions, molarity calculations, manipulating excel files, database management, etc.).Strong communication skills, with a background in molecular biology and cell culture preferred. Applicants intending on progressing to graduate school are encouraged to apply. A college degree (preferred) and laboratory experience is required.Associate will work closely with the principal investigator, potentially resulting in first-author publications and conference presentations.Salary competitive and commensurate with experience. Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category: Administration Lab/Area: GIND Administration Description: The Gladstone Institutes are a renowned center of excellence focused on using science to overcome disease. We are an independent, not-for-profit research organization affiliated with the University of California San Francisco (UCSF) and located in an award winning building at UCSF's Mission Bay Campus. We aim to contribute to the health and well being of all people through research, education and outreach in the areas of neuroscience, brain disorders, cardiovascular disease, stem cell technology, virology and immunology. In light of its many burgeoning areas of research and related fundraising needs, the Gladstone Institute of Neurological Disease seeks an experienced grant writer to assist its investigators in the preparation of grant applications, including complex center, program project, translational, equipment, and training grant proposals to the National Institutes of Health, and funding requests to diverse private foundations. Qualifications Candidates should have a well established track record of critically contributing to the preparation and successful competition for such grants, as well as outstanding verbal and written communication skills. They should be able to quickly grasp complex scientific issues and be thoroughly familiar with the policies, guidelines and practices of relevant funding agencies. The position also requires exceptional organizational skills, ability to multi-task, efficiency, and initiative. Advanced degrees (MD or PhD) and postdoctoral training in neuroscience would be viewed as additional strengths. The successful candidate will have the opportunity to help a dynamic and highly interactive group of investigators elucidate fascinating brain functions and overcome devastating neurological diseases. Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category: Science Lab/Area: Bioinformatics Core Description: We are seeking a talented Statistician at either junior or senior levels to join the dynamic bioinformatics/data science team here at Gladstone Institutes. You will be providing statistical support to the world-class biomedical research conducted in labs at Gladstone Institutes, UCSF, and beyond. Working closely with experimental scientists, you will lead end-to-end studies from hypotheses and experimental design, to analysis plans, implementation and pipelining, to methods assessment and result reporting or publication. You will be working with a variety of data types generated by various platforms and technologies (eg, genome sequencing, bulk RNA-seq, single cell analysis, ChIP-seq, ATAC-seq, metagenomics, CRISPR screens, mass spectrometry, and others). Expertise and knowledge of state-of-the art sequencing tools/platforms, analysis methods and annotation methods are preferred but not required. You will have opportunities for teaching, authorship, methods development, grant applications, and further training to develop your expertise and skill sets. We accommodate a flexible working schedule to facilitate work-life balance. Qualifications MS in Statistics or similar quantitative fields and at least 2 + years experience with analysis of sequence data, large biological datasets using R, Python, Perl or equivalent is required PhD in Statistics or similar quantitative fields and experience with analysis of sequence data, large biological datasets using R, Python, Perl or equivalent is required. Statistical genetics experience or experience incorporating various biological data types is strongly preferred. Prior consulting or industrial experience supporting research is a plus. The successful candidate will have a strong background in computational science, statistical analysis, experimental design, and quantitative analysis of biological systems, as well as a demonstrated ability to communicate and work effectively with all types and levels of internal and external collaborators. Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category: Science Lab/Area: Weinberger Lab Description: We are looking for a Senior Research Associate to join the Weinberger lab. The person in this position will be responsible for DNA purification, PCR, molecular cloning, molecular biology, cloning, PCR, sequencing, extensive cell culture, viral purification, and microscopy. Ordering, stocking and general laboratory management and maintenance will also be required. Grant writing responsibilities. Qualifications AA/AS degree in a related field and 9+ years of related experience. B.S./B.A., in a related field and 7+ years of related experience MS degree in related field and 5+ years of related experience Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category: Administration Lab/Area: Facilities Description: We are currently recruiting for a Senior Building Engineer. The person in this position will perform engineering tasks associated with preventive and corrective maintenance of building equipment and building systems. The will gain thorough knowledge of all building systems, and building management system, and how they integrate, helping to ensure that these systems perform their intended function. Respond to, and perform Facilities Queue requests in a timely and efficient manner. Work with the Facilities Team to ensure a safe working environment for all Gladstone personnel, and help improve overall energy efficiency of building. Provide emergency response as needed, and serve in On Call capacity a minimum of one week per month. Qualifications Associate's Degree and/or vocational or technical school degree in Boiler Operation, HVAC, Basic Mechanics or Electrical Theory required. Five or more years of hands-on experience with boilers, HVAC, electrical, building automation systems, lab utilities, and interacting with system end-users preferred/required. Carpentry and/or painting skills, and experience with Computerized Maintenance Management Systems, CMMS, desired. Two or more years of supervisor/lead experience is preferred. Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category: Science Lab/Area: Huang Lab Description: Gladstone's Center for Translational Advancement (GCTA) seeks aResearch Associate II/IIIin human iPSC culture and stem cell technique to help develop and take charge of the large-scale stem cell culture, differentiation, and maintenance pipeline for our large-scale drug re-positioning effort. This candidate will have the opportunity to shape and take ownership of a critical component of the new center's drug re-purposing infrastructure. Develop and maintain the pipeline for consistent production of multiple iPSC-derived cell types at scale. Responsible for the culture, maintenance, propagation, and differentiation of the cell lines. Differentiation of human iPSC lines into neural and glial cell types, using consensus protocols. Provide regular quality assurance reports detailing culture quality, consistency, and cleanliness. Provide training to incoming researchers where necessary. Exercise resourcefulness, creativity and proactivity to seek out answers to unforeseen difficulties or problems outside range of expertise. Implement operational modifications where necessary to improve accuracy, efficiency, and cost-effectiveness Qualifications BS or MS in a field of BiologicalSciences required. 2+ years' experience in a laboratory setting applying human stem cell culture techniques. Must be skilled in pluripotent human stem cell culture, propagation and differentiation, with excellent aseptic technique. Large-scale drug screening experience preferred. Exceptional organizational and documentation skills. Previous experience starting a lab or building a cell-culture program would be ideal. The ideal candidate will be personally motivated to accelerate the development of underutilized compounds into treatments for under-treated diseases. S/he will thrive in an environment of team science, where many minds rally around a common goal, in a culture of support and collaboration. The objective of the person in this position will be to build and run a robust, large-scale pipeline for consistent production of multiple brain cell types from human iPSCs, for screening with FDA-approved compounds, with the goal of re-purposing those compounds for new treatments for neurological and neurodegenerative diseases. About the Gladstone Center for Translational Advancement The Gladstone Center for Translational Advancement (GCTA) was created in 2017 to find unforeseen uses for existing drugs. Seeking new uses for FDA-approved drugs, which have already passed safety tests, can help bring treatments to patients more quickly. This "drug re-purposing" approach drastically lowers the cost and shortens the timeline of drug development. Headed by Senior InvestigatorYadong Huang, MD, PhD, the center provides crucial resources to develop re-purposed drugs that target diseases of the central nervous system, the heart, and the immune system. The center aims to accelerate the conversion of basic research findings into efficient clinical candidates and, ultimately, medical applications. The center includes three major components: Build a drug repositioning database of up to 15,000 compounds using human cells derived from induced pluripotent stem cells (iPSCs). The database will outline how each drug affects healthy and diseased human genes. Establish infrastructure to test repurposed drugs in cell culture and animal models for potency, pharmacokinetic (PK), and pharmacodynamic (PD) studies in collaboration with Gladstone Senior Investigator Sheng Ding and the School of Pharmaceutical Sciences at the Tsinghua University in Beijing. Promote human clinical trials of re-purposed drugs, in collaboration with medical centers and pharmaceutical companies in the US and abroad. Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category: Science Lab/Area: Krogan Lab Description: We are currently recruiting for a Research Associate for the Krogan lab at the Gladstone Institutes: Host-Virus Interactions You will be working on projects focused on studying host-virus interactions to help determine the host factors and pathways hijacked by viruses such as Ebola and SARS-CoV-2 for their own replication. Your role will include generating cell lines expressing affinity tagged viral proteins, affinity purification and sample preparation for mass spectrometry analysis, molecular biology, and cell-based reporter assays to study viral replication. This role is an excellent opportunity to learn a number of valuable, cutting-edge techniques in cell biology, proteomics, and cell culture while working with a dynamic and interdisciplinary research team. At the Mission Bay campus in San Francisco, you will join the lab of professor Nevan Krogan at the Gladstone Institutes and his team at UCSF ( ). The Krogan lab is a highly dynamic and collaborative laboratory, applying proteomics and functional genomics to unravel the molecular networks underpinning a broad range of complex biological and biomedical problems, including infectious disease, cancer, neurological and psychiatric disorders. Our ideal applicant is a problem solver with a positive attitude, excellent organizational and interpersonal skills, and the ability to learn and implement methodology efficiently. Skills required: • Associate's, Bachelor's or Master's degree, with 1-2 years of work experience(depending on degree), in biological sciences or an appropriate scientific field. • Molecular biology techniques including molecular cloning, PCR, and western blotting. • Mammalian cell culture experience. • Able to work independently and meet deadlines; recognize and resolve problems while maintaining a high level of organization. • Effective verbal and written communication skills to interface with the team to review and analyze the results. • Microsoft Office (Word, Excel, and/or Powerpoint). Preferred skills: • Generating stable cell lines and characterizing them. • Transfection or viral transduction. • Affinity purifications of proteins. • Preparation for samples for mass spectrometric analysis. • Experience with CRISPR • Experience with statistical data analysis. Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category: Science Lab/Area: Nakamura Lab Description: We are currently recruiting for a Research Associate I for the Nakamura Lab. The research associate will be assisting with studies investigating mitochondrial dysfunction in the pathogenesis of neurodegenerative disease, and characterizing genetic pathways that regulate energy levels. This position is intensive in benchwork, and careful technique and record keeping are critical skills. Common techniques used in the laboratory include: preparation of rodent and human neuronal cultures, maintenance of mammalian cell lines, cloning, flow cytometry, CRISPR-based screens, assays of cellular metabolism, fluorescence microscopy, immunohistochemistry, and work with mouse models of Parkinson's disease and Alzheimer's disease. This position will be research based with opportunity for publication. The skills and experiences acquired from this position could provide a useful background for future pursuits in medical and/or bioscience graduate school. Required qualifications are a high level of motivation, strong problem solving skills, excellent organization and attention to detail, the ability to work well in a team environment and a track record of academic excellence. Preferred qualifications include an undergraduate background in biological sciences, and experience with tissue culture, flow cytometry, lentiviral vectors and/or molecular biology. Minimum Qualifications Associate Degree and 2+ years of related experienc BS/BA (preferred) in a related field and ) years of relate experience An equivalent combination of education and experience Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category: Science Lab/Area: Conklin Lab Description: Technical Knowledge Applies technical knowledge of the principles, concepts and methods of scientific research to investigate a scientific problem Major Job Accountabilities Research Associate position in the Conklin laboratory at the Gladstone Institutes at Mission Bay (see ). Project on human therapeutic editing in close collaboration with the Innovative Genomics Institute. Projects focused on the basic mechanism of DNA repair, DNA-excision with motor neuron, retinal, cardiac diseases as model systems. Strong communication skills, with a background in molecular biology and cell culture preferred. Applicants intending on progressing to graduate school are encouraged to apply, however we ask for a two year minimum commitment. A college degree and laboratory experience required. Salary competitive and commensurate with experience. inquires: Typical Work Assignments iPSC culture and differentiation CRISPR genome editing Molecular biology Independence/ Guidance Work is guided by general instructions on routine work and detailed instructions on new assignments Resolves routine and recurring problems within own work area Uses discretion in prioritizing and organizing workflow Ability to independently conduct a wide variety of standard laboratory techniques/procedures May provide interpretation and initial analyses of results Assists in designing experiments to complete a segment of overall research plan Communication Able to communicate verbally in a clear and concise manner Demonstrates understanding of directions by providing regular feedback on work activities Asks questions to gather additional information. Maintains communication with other labs, committees, collaborators and external personnel Assists with the preparation of technical reports, summaries and quantitative analyses Collaborates with internal staff and external institutions and/or experts on research activities Prepares and participates in meetings, presentations and scientific discussions. Scope Makes innovative intellectual and technical contributions to the research program Minimum Qualifications BS/BA in a related field and 0 years of related experience or An equivalent combination of education and experience Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category: Administration Lab/Area: Finance Description: Essential Function: Processes bi-weekly check run, including verifying the accuracy of invoices, reconciling all related reports, obtaining appropriate signatories and mailing/distributing signed checks. Processes all PO invoices and credit memos, ensuring that appropriate signature authority is obtained when necessary. Maintains all department filing systems, including vendor invoices, journal entries and completed checks. Provides backup assistance for accounts payable functions, which includes processing employee reimbursements and vendor check requests, including verification of signature authority and account distribution. Tracks all problem invoices for resolution and follows up when necessary, which includes working with the Purchasing department, other staff and outside vendors to ensure timely resolution. Opens, stamps and distributes all department mail daily in accordance with policies. Monitors the Accounts Payable email account in order to resolve and respond to inquiries on a timely basis. Ensures adherence to internal procedures and government / private agency grant accounting principles. Performs other duties as assigned. Education Requirements: Associate's Degree or vocational/technical school degree in Accounting. Experience Requirements: One year of experience in the accounting field, including experience working with general ledger accounts. Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.

Category: Science Lab/Area: Marson Lab Description: The Marson lab is recruiting a Research Associate (RA) to help perform in vivo experiments in mouse models of immunotherapies and assist with the management of the mouse colony used for ongoing multidisciplinary cellular engineering projects. Our lab has pioneered the application of novel genetic engineering technologies such as CRISPR to primary human immune cells (Schumann et al., PNAS 2015). These new technical abilities have furthered our labs research into the genetic underpinnings of autoimmune disease and T cell biology (Farh and Marson et al., Nature 2015), as well as opened the door to novel cancer immunotherapies based on engineered human immune cells (Roth et al., Nature 2018). In addition to cell editing, our lab integrates genomic analysis (e.g. ChIP-seq, ATAC-seq, RNA-seq), human disease genetics, and high dimensional screening approaches for in vitro and in vivo studies of T cell function (Simeonov et al. Nature 2017; Shifrut and Carnevale et al. Cell 2018; Roth et al., Cell , 2020). Key responsibilities: The RA will assist with the management and maintenance of the lab's mouse colonies located at Gladstone and UCSF. Tasks require routine handling of mice. Perform intravenous injections of cancer cell lines and/or immune cells. Help perform experiments in murine models of cancer, autoimmunity and infections. Perform in vivo imaging in cancer models (bioluminescence) . Perform all colony management duties, including but not limited to injections, plug checks, post-operative care, and identification and aging of new litters. Manage breeding, timed breeding, ear punching/ear tagging/tailing for genotyping, weaning, aging and sexing of pups, and euthanasia. Identify and implement required care for mice with health issues and mice on special treatment (special diet, fasting, treated water). Maintain a detailed mouse database, and update the mouse lines listed in the UCSF inventory database with high accuracy. Administer medication/reagents orally and via subQ, IP, or IV. Collect blood samples or dissect other tissues/organs for analysis. Design PCR primers and perform PCR for genotyping. Send out and track tail and sequencing samples for genotyping. Request sperm cryopreservation. Manage mouse lines with the Cre/loxP system. Monitor, order, and restock consumables in the mouse room as necessary. Communicate effectively with LARC personnel (animal technician, floor leader, facility supervisor, vet nurse), and with lab mouse users. Assist with any experiments using mouse models. Order, transfer, and import/export mice. Write and update Standard Operating Procedures (SOP) and protocols. Other duties as assigned. Required Qualifications: • BA/BS degree and one or more years of laboratory experience utilizing techniques or methods required by the position; or an equivalent combination of education and experience • Must be able to work with mouse colonies • Experience with general laboratory techniques, especially basic molecular and cellular biology techniques (including but not limited to DNA and RNA isolation, PCR, gel electrophoresis, DNA assembly, bacterial transformation, mammalian cell culture, etc.) • Excellent attention to detail, organizational and interpersonal communication skills (verbal and written) • Willingness and ability to learn new methods and skills for changing research priorities • Ability to work independently and as a member of a research team • Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines • Ability to comply with policies and procedures • Some evening and weekend hours are required Preferred Qualifications: • Prior experience with mammalian cell culture, especially T cell culture • Prior experience with DNA sequencing technologies, including Sanger and NGS • Prior experience with next-generation sequencing library preparations and quality control The Marson lab is a member of the joint Gladstone-UCSF Institute of Genomic Immunology. The Institute is committed to improving diversity, equity, and inclusion in the genomic immunology field, from trainees to faculty, and is an equal opportunity employer. Additional Information: Title and salary will be commensurate with education and experience. Be a part of big ideas and consider Gladstone. Your difference will make a difference in human health. Gladstone is an equal opportunity employer.