Position Summary: The RNA Rewriting group is seeking a Scientist to support the molecular characterization of novel gene writers to advance candidate selection efforts. We are looking for a highly independent, enthusiastic, and self-motivated individual to work on various aspects of the gene writers' characterization. This individual will join a dynamic, collaborative and rapidly growing team. Key Responsibilities: • Develop and lead new projects, experiments, scientific processes to support characterization of novel rewriters. • Actively undertake technology development efforts in the gene editing space. • Keep up with advances in genomics and genome engineering and strategize on prioritizing and onboarding cutting-edge technologies to advance R&D efforts. Basic Qualifications: · Deep understanding of and experience in carrying out on and off-target characterization in the CRISPR-Cas9 context. · Expertise in characterizing DNA and RNA binding proteins, including use of ChIP/RIP-Seq. · Experience in building out NGS pipelines: Illumina based DNA and RNA library construction, QC using TapeStation and fragment analyzer, running a MiSeq/ NextSeq. · Extensive experience in mammalian cell culture of primary and cancer cell lines (U2OS, HEK293, etc.). · Experience in independently developing and leading projects. · Ability to work in a cross-functional, multi-disciplinary environment and in an agile and highly collaborative fashion. · Strong attention to detail with respect to executing experiments and record-keeping and experience with electronic lab notebook maintenance. Preferred Experience (not required): · Experience with mouse/ human primary hepatocytes, iPSCs, 3D cell culture · Experience with long read sequencing technologies · Experience with liquid handling and automated NGS pipelines Education and relevant work experience: · Ph.D. in biological sciences. Title commensurate with experience.
09/25/2021
Full time
Position Summary: The RNA Rewriting group is seeking a Scientist to support the molecular characterization of novel gene writers to advance candidate selection efforts. We are looking for a highly independent, enthusiastic, and self-motivated individual to work on various aspects of the gene writers' characterization. This individual will join a dynamic, collaborative and rapidly growing team. Key Responsibilities: • Develop and lead new projects, experiments, scientific processes to support characterization of novel rewriters. • Actively undertake technology development efforts in the gene editing space. • Keep up with advances in genomics and genome engineering and strategize on prioritizing and onboarding cutting-edge technologies to advance R&D efforts. Basic Qualifications: · Deep understanding of and experience in carrying out on and off-target characterization in the CRISPR-Cas9 context. · Expertise in characterizing DNA and RNA binding proteins, including use of ChIP/RIP-Seq. · Experience in building out NGS pipelines: Illumina based DNA and RNA library construction, QC using TapeStation and fragment analyzer, running a MiSeq/ NextSeq. · Extensive experience in mammalian cell culture of primary and cancer cell lines (U2OS, HEK293, etc.). · Experience in independently developing and leading projects. · Ability to work in a cross-functional, multi-disciplinary environment and in an agile and highly collaborative fashion. · Strong attention to detail with respect to executing experiments and record-keeping and experience with electronic lab notebook maintenance. Preferred Experience (not required): · Experience with mouse/ human primary hepatocytes, iPSCs, 3D cell culture · Experience with long read sequencing technologies · Experience with liquid handling and automated NGS pipelines Education and relevant work experience: · Ph.D. in biological sciences. Title commensurate with experience.
Join us at Jumpcode Genomics to help shape the genomics revolution. Established in 2016, Jumpcode is a dynamic company with proprietary CRISPR technology that enables research and clinical Next Generation Sequencing (NGS) applications. We are on a mission to provide our customers with innovative genomic solutions that make the previously impossible, possible. Our products cut through the noise by removing unwanted nucleic acid molecules so customers can see what really matters. Are you ready to be a part of this unique and exciting company? Research Associate at Jumpcode The Research Associate performs experiments in the laboratory and generates next generation sequencing (NGS) data to support the development of Jumpcode products. The Research Associate is responsible for the development of NGS-based genomics workflows, including, but not limited to, those for targeted, whole genome and whole transcriptome sequencing. Key responsibilities Performs experiments involving gel electrophoresis, qPCR, digital PCR and/or next generation sequencing to evaluate and develop JumpCode products. Prepares and evaluates NGS libraries for various applications As a member of a project team, may assist in the design of laboratory experiments, techniques, and protocols. Operates and maintains instrumentation critical for lab operations including NGS, digital PCR etc. Tracks sample data and project timelines through a laboratory information management system and electronic laboratory notebook. Responsible for maintaining accurate laboratory logs and records. Maintains sequencing instrumentation and laboratory facilities, troubleshoots instrument and sequencing issues when needed. Other duties may include lab inventory, instrument maintenance and updating SOPs and generating reports as necessary. Executes routine lab work including material handling and downstream molecular testing etc. May assist in performing product quality control May help with data analysis with the bioinformatics team. May work collaboratively with others to develop new products and applications Assists with laboratory clean up and organization. Performs daily, weekly, and monthly equipment maintenance as directed. May operate and develop protocols for high-throughput liquid handling instruments. Presents results at R&D meetings. The ideal background for success Typically requires a minimum of 3 years of related experience and a Bachelor's degree in a scientific/engineering discipline, or at least 1 year of relevant experience and a Master's degree; or equivalent combination of education and experience. Specific experience in the field of next generation sequencing (NGS) and CRISPR technology with an educational background in biology, biochemistry, biophysics, molecular or cellular biology. Familiarity with NGS protocols and instruments. Proficiency with use of general laboratory instruments. Experience in a wet lab environment and working collaboratively with both wet and dry lab scientists. Exceptional communication skills with the ability to collaborate, seek constructive feedback, build relationships, promote teamwork, and remain flexible and open-minded. Able to quickly adapt to change. Ready to take control of your career with Jumpcode? We are all about inclusivity, integrity, and innovation. If you enjoy a fast-paced and collaborative environment, Jumpcode may be for you. We revel in what we do but know life is not all about work. We provide a competitive employee package, including health benefits and flexible time off. We are committed to building a team that represents our global market. We hire the most qualified candidates, those who live our values, offer new perspectives, and can achieve superb results.
01/28/2021
Full time
Join us at Jumpcode Genomics to help shape the genomics revolution. Established in 2016, Jumpcode is a dynamic company with proprietary CRISPR technology that enables research and clinical Next Generation Sequencing (NGS) applications. We are on a mission to provide our customers with innovative genomic solutions that make the previously impossible, possible. Our products cut through the noise by removing unwanted nucleic acid molecules so customers can see what really matters. Are you ready to be a part of this unique and exciting company? Research Associate at Jumpcode The Research Associate performs experiments in the laboratory and generates next generation sequencing (NGS) data to support the development of Jumpcode products. The Research Associate is responsible for the development of NGS-based genomics workflows, including, but not limited to, those for targeted, whole genome and whole transcriptome sequencing. Key responsibilities Performs experiments involving gel electrophoresis, qPCR, digital PCR and/or next generation sequencing to evaluate and develop JumpCode products. Prepares and evaluates NGS libraries for various applications As a member of a project team, may assist in the design of laboratory experiments, techniques, and protocols. Operates and maintains instrumentation critical for lab operations including NGS, digital PCR etc. Tracks sample data and project timelines through a laboratory information management system and electronic laboratory notebook. Responsible for maintaining accurate laboratory logs and records. Maintains sequencing instrumentation and laboratory facilities, troubleshoots instrument and sequencing issues when needed. Other duties may include lab inventory, instrument maintenance and updating SOPs and generating reports as necessary. Executes routine lab work including material handling and downstream molecular testing etc. May assist in performing product quality control May help with data analysis with the bioinformatics team. May work collaboratively with others to develop new products and applications Assists with laboratory clean up and organization. Performs daily, weekly, and monthly equipment maintenance as directed. May operate and develop protocols for high-throughput liquid handling instruments. Presents results at R&D meetings. The ideal background for success Typically requires a minimum of 3 years of related experience and a Bachelor's degree in a scientific/engineering discipline, or at least 1 year of relevant experience and a Master's degree; or equivalent combination of education and experience. Specific experience in the field of next generation sequencing (NGS) and CRISPR technology with an educational background in biology, biochemistry, biophysics, molecular or cellular biology. Familiarity with NGS protocols and instruments. Proficiency with use of general laboratory instruments. Experience in a wet lab environment and working collaboratively with both wet and dry lab scientists. Exceptional communication skills with the ability to collaborate, seek constructive feedback, build relationships, promote teamwork, and remain flexible and open-minded. Able to quickly adapt to change. Ready to take control of your career with Jumpcode? We are all about inclusivity, integrity, and innovation. If you enjoy a fast-paced and collaborative environment, Jumpcode may be for you. We revel in what we do but know life is not all about work. We provide a competitive employee package, including health benefits and flexible time off. We are committed to building a team that represents our global market. We hire the most qualified candidates, those who live our values, offer new perspectives, and can achieve superb results.
Staff Electrical Engineer Pacific Biosciences of California, Inc. (NASDAQ: PACB) is helping scientists forge a better understanding of biology by providing a unique long-read sequencing technology that generates more complete and accurate data, giving them more insights. Our sequencing systems allow scientists to characterize genomes, transcriptomes, and epigenomes from any organism. Scientists use our technology in areas such as human biomedical research, plant and animal sciences, and microbiology and infectious disease studies. Become part of the new paradigm in long-read sequencing and help shape the future of genomic study by joining the Pacific Biosciences team. Pacific Biosciences is looking for an experienced staff electrical engineer to architect and implement electronic subsystems for our next generation SMRT sequencing instruments. This person will work with Systems Engineers to understand and refine requirements, document and champion hardware architecture options, drive interdisciplinary design reviews and implement solutions from an optimal blend of off-the-shelf and custom components. This person should be comfortable implementing complex mixed analog & digital circuit boards, as well as FPGA designs. This successful candidate must have excellent oral and written communication skills and excel in effective collaboration with mechanical, optical, software, manufacturing, and systems subject matter experts within the department as well as program management. The candidate must feel comfortable inspiring and leading through innovation and discovery. Ideally the candidate has experience with semiconductor capital equipment, laboratory instruments or similar products. Responsibilities Present and champion compelling solutions to both business and technical audiences. Explore technology trends and their applicability to Pacific Biosciences next generation products. Collaborate with Product Management, Systems Engineering, Optical, Mechanical and System Integration teams to refine hardware requirements. Work with stakeholders across the company to understand product needs and implement solutions that meet business goals for quality, schedule, and cost. Design and implementation of complex mixed analog and digital custom circuit board, including programmable logic. Transition deliverables to mass production in collaboration with manufacturing NPI. Collaborate with manufacturing on product sustaining activities. All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities. Requirement Bachelors and/or Masters in Electrical Engineering or related discipline with 10+ years of work experience. Possess an analytical mindset and extensive experience with electronic and FPGA design. Experience architecting and implementing complex high performance embedded systems. Demonstrated competency in electronics and computer architecture and transitioning products to manufacturing. Familiarity with High Performance Compute (HPC) architectures is desirable. Excellent interpersonal, verbal, and written communication skills. Excellent analytical and problem-solving skills, a strong team player, able to take initiative, detail-oriented, and able to work effectively as part of a strong hardware team. Thrives in a fast-paced environment, interacting with scientists and engineers from a variety of disciplines. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
01/26/2021
Full time
Staff Electrical Engineer Pacific Biosciences of California, Inc. (NASDAQ: PACB) is helping scientists forge a better understanding of biology by providing a unique long-read sequencing technology that generates more complete and accurate data, giving them more insights. Our sequencing systems allow scientists to characterize genomes, transcriptomes, and epigenomes from any organism. Scientists use our technology in areas such as human biomedical research, plant and animal sciences, and microbiology and infectious disease studies. Become part of the new paradigm in long-read sequencing and help shape the future of genomic study by joining the Pacific Biosciences team. Pacific Biosciences is looking for an experienced staff electrical engineer to architect and implement electronic subsystems for our next generation SMRT sequencing instruments. This person will work with Systems Engineers to understand and refine requirements, document and champion hardware architecture options, drive interdisciplinary design reviews and implement solutions from an optimal blend of off-the-shelf and custom components. This person should be comfortable implementing complex mixed analog & digital circuit boards, as well as FPGA designs. This successful candidate must have excellent oral and written communication skills and excel in effective collaboration with mechanical, optical, software, manufacturing, and systems subject matter experts within the department as well as program management. The candidate must feel comfortable inspiring and leading through innovation and discovery. Ideally the candidate has experience with semiconductor capital equipment, laboratory instruments or similar products. Responsibilities Present and champion compelling solutions to both business and technical audiences. Explore technology trends and their applicability to Pacific Biosciences next generation products. Collaborate with Product Management, Systems Engineering, Optical, Mechanical and System Integration teams to refine hardware requirements. Work with stakeholders across the company to understand product needs and implement solutions that meet business goals for quality, schedule, and cost. Design and implementation of complex mixed analog and digital custom circuit board, including programmable logic. Transition deliverables to mass production in collaboration with manufacturing NPI. Collaborate with manufacturing on product sustaining activities. All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities. Requirement Bachelors and/or Masters in Electrical Engineering or related discipline with 10+ years of work experience. Possess an analytical mindset and extensive experience with electronic and FPGA design. Experience architecting and implementing complex high performance embedded systems. Demonstrated competency in electronics and computer architecture and transitioning products to manufacturing. Familiarity with High Performance Compute (HPC) architectures is desirable. Excellent interpersonal, verbal, and written communication skills. Excellent analytical and problem-solving skills, a strong team player, able to take initiative, detail-oriented, and able to work effectively as part of a strong hardware team. Thrives in a fast-paced environment, interacting with scientists and engineers from a variety of disciplines. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
Sanaria is a rapidly growing, diverse, inclusive, multi-cultural, biotechnology company at the cutting edge of vaccine innovation. We are passionate about our goal to eradicate malaria. Our related company Protein Potential has an opening for Scientist, Protein Engineering and Production, to join their team. Protein Potential employees are exceptional scientifically, mission-driven, and play a variety of roles in research, product development, manufacturing, clinical trials, and support of these endeavors. We offer a strong benefits package including company paid life and disability insurance, health plans with employee and dependent subsidy, and 401k plan with company match. Position Purpose: Conceives, designs, conducts and leads advanced independent or multi-disciplinary research driven by strategic business needs in product, assay, process, method-or system-integration development. Responsible for initiating, directing and executing scientific research, development and manufacturing process strategies to support new and existing products. Investigates the feasibility of applying a wide variety of scientific principles and concepts to potential inventions and products. Makes contributions to scientific literature and conferences. Ability to lead, manage and participate in team projects internally as well as with outside collaborators. Essential Duties and Responsibilities: This is an active laboratory based position. This position is primarily responsible for scientific input and guidance as well as execution and documentation for the development of recombinant protein-based or Salmonella typhi Ty21a-based live attenuated oral vaccines. Essential duties must include managing, interacting and coordination of internal and external collaborators. Knowledge and Abilities : Knowledge and hands-on experience in biochemical characterization of proteins and nucleic acids and process development in recombinant protein purification. Knowledge and technical proficiency in microbiological and molecular genetics. Hands-on experience in recombinant DNA technologies and genome manipulation of microorganisms. Ability to effectively communicate with broad scientific audience both orally and in writing. GLP, cGMP and cGCP trainings. Education and Work Experience PhD with 3-5 years post doctorate. Excellent interpersonal and communication skills. Ability to work independently in a fast-paced environment and to collaborate effectively on a team. Industry and GMP experience a plus. Please send cover letter, resume and required pay rate with subject line "Scientist, Protein Engineering." For more information, please visit www.proteinpotential(dot)com . Protein Potential is an Equal Opportunity Employer.
01/25/2021
Full time
Sanaria is a rapidly growing, diverse, inclusive, multi-cultural, biotechnology company at the cutting edge of vaccine innovation. We are passionate about our goal to eradicate malaria. Our related company Protein Potential has an opening for Scientist, Protein Engineering and Production, to join their team. Protein Potential employees are exceptional scientifically, mission-driven, and play a variety of roles in research, product development, manufacturing, clinical trials, and support of these endeavors. We offer a strong benefits package including company paid life and disability insurance, health plans with employee and dependent subsidy, and 401k plan with company match. Position Purpose: Conceives, designs, conducts and leads advanced independent or multi-disciplinary research driven by strategic business needs in product, assay, process, method-or system-integration development. Responsible for initiating, directing and executing scientific research, development and manufacturing process strategies to support new and existing products. Investigates the feasibility of applying a wide variety of scientific principles and concepts to potential inventions and products. Makes contributions to scientific literature and conferences. Ability to lead, manage and participate in team projects internally as well as with outside collaborators. Essential Duties and Responsibilities: This is an active laboratory based position. This position is primarily responsible for scientific input and guidance as well as execution and documentation for the development of recombinant protein-based or Salmonella typhi Ty21a-based live attenuated oral vaccines. Essential duties must include managing, interacting and coordination of internal and external collaborators. Knowledge and Abilities : Knowledge and hands-on experience in biochemical characterization of proteins and nucleic acids and process development in recombinant protein purification. Knowledge and technical proficiency in microbiological and molecular genetics. Hands-on experience in recombinant DNA technologies and genome manipulation of microorganisms. Ability to effectively communicate with broad scientific audience both orally and in writing. GLP, cGMP and cGCP trainings. Education and Work Experience PhD with 3-5 years post doctorate. Excellent interpersonal and communication skills. Ability to work independently in a fast-paced environment and to collaborate effectively on a team. Industry and GMP experience a plus. Please send cover letter, resume and required pay rate with subject line "Scientist, Protein Engineering." For more information, please visit www.proteinpotential(dot)com . Protein Potential is an Equal Opportunity Employer.
Regeneron Pharmaceuticals, Inc.
Tarrytown, New York
We are seeking a highly motivated scientist to join the Genome Engineering Technology group, which addresses a wide range of experimental topics, including genome editing, stem cell differentiation, and antibody engineering. Our ideal candidates are collaborative scientists that have proven strong intellectual curiosity, scientific independence, and a desire to develop technologies or new therapeutics. Preferred candidates will have expertise in multiple fields of study, with a preference given to the following areas: genome editing, gene therapy, protein or antibody engineering, or omic methods. The scientist will be expected to initiate new avenues of research, as well as support ongoing projects. As a Scientist in the Genome Engineering Technology group a typical day may include the following: - Design and conduct experiments and provide advanced data analysis, as well as trouble shooting under minimal supervision. - Provide scientific and technical supervision to junior staff, including initial training, ongoing instruction, planning detailed procedures for defined projects with timelines, methodological approaches, expected results and necessary resources. - Maintain scientific curiosity and familiarity with current advances in emerging technologies and literatures, and apply such knowledge toward development of new or improved research directions. - Maintain clear records of experimental details in an electronic laboratory notebook. - Communicate experimental results, conclusions and ideas directly to supervisor, project team members, and management in presentation form. This role may be for you if: - You enjoy and are passionate about bench science - You are able to work independently with minimal supervision - You have a positive attitude and willingness to learn and contribute in a goal-oriented team To be considered for this position you must have a PhD and 3+ years of relevant experience in molecular biology, cell biology, immunology, cancer biology or related field. A track record of independent scientific achievement and problem solving as proven through publications. Please note, occasional weekend and/or evening hours required . Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
01/23/2021
Full time
We are seeking a highly motivated scientist to join the Genome Engineering Technology group, which addresses a wide range of experimental topics, including genome editing, stem cell differentiation, and antibody engineering. Our ideal candidates are collaborative scientists that have proven strong intellectual curiosity, scientific independence, and a desire to develop technologies or new therapeutics. Preferred candidates will have expertise in multiple fields of study, with a preference given to the following areas: genome editing, gene therapy, protein or antibody engineering, or omic methods. The scientist will be expected to initiate new avenues of research, as well as support ongoing projects. As a Scientist in the Genome Engineering Technology group a typical day may include the following: - Design and conduct experiments and provide advanced data analysis, as well as trouble shooting under minimal supervision. - Provide scientific and technical supervision to junior staff, including initial training, ongoing instruction, planning detailed procedures for defined projects with timelines, methodological approaches, expected results and necessary resources. - Maintain scientific curiosity and familiarity with current advances in emerging technologies and literatures, and apply such knowledge toward development of new or improved research directions. - Maintain clear records of experimental details in an electronic laboratory notebook. - Communicate experimental results, conclusions and ideas directly to supervisor, project team members, and management in presentation form. This role may be for you if: - You enjoy and are passionate about bench science - You are able to work independently with minimal supervision - You have a positive attitude and willingness to learn and contribute in a goal-oriented team To be considered for this position you must have a PhD and 3+ years of relevant experience in molecular biology, cell biology, immunology, cancer biology or related field. A track record of independent scientific achievement and problem solving as proven through publications. Please note, occasional weekend and/or evening hours required . Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
Senior Manager / Director, Electrical Engineering Pacific Biosciences of California, Inc. (NASDAQ: PACB) is helping scientists forge a better understanding of biology by providing a unique long-read sequencing technology that generates more complete and accurate data, giving them more insights. Our sequencing systems allow scientists to characterize genomes, transcriptomes, and epigenomes from any organism. Scientists use our technology in areas such as human biomedical research, plant and animal sciences, and microbiology and infectious disease studies. Become part of the new paradigm in long-read sequencing and help shape the future of genomic study by joining the Pacific Biosciences team. Pacific Biosciences is looking for an experienced electrical engineering leader to oversee the development and upkeep of the electronic subsystems for our next generation SMRT sequencing instruments. This person will coordinate a cross disciplinary electrical and FPGA engineering team that is architecting, developing and integrating complex and high-performance subsystems integral to our DNA sequencing products. This person will orchestrate hardware research and development activities related to low level embedded control, high performance sensor data capture and high-performance computing. This successful candidate must have excellent oral and written communication skills and be able to effectively interface with mechanical, optical, software and systems leaders within the department as well as cross departmental leaders in manufacturing and program management. Responsibilities Lead the design and development of the instrument electronics architecture. Work with stakeholders across the company to understand product needs and implement solutions that meet business goals for quality, schedule, and cost. Develop plans and timelines, work with program management to integrate plans into a larger program. Participate in crafting budget for area of responsibility. Transition deliverables to mass production in collaboration with manufacturing NPI. Collaborate with manufacturing on product sustaining activities Select and manage external technology development partners. Attract, develop, and retain an engaged electrical and FPGA engineering team. Requirement Bachelors and/or Masters in Electrical Engineering or related discipline with 10+ years of work experience. Possess an analytical mindset and experience with electronic and FPGA design. Experience managing and architecting complex high performance embedded systems. Demonstrated competency in electronics and computer architecture and transitioning products to manufacturing. Excellent interpersonal, verbal, and written communication skills. Excellent analytical and problem-solving skills, a strong team player, able to take initiative, detail-oriented, and able to work effectively as part of a management team. Thrives in a fast-paced environment, interacting with scientists and engineers from a variety of disciplines. All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
01/22/2021
Full time
Senior Manager / Director, Electrical Engineering Pacific Biosciences of California, Inc. (NASDAQ: PACB) is helping scientists forge a better understanding of biology by providing a unique long-read sequencing technology that generates more complete and accurate data, giving them more insights. Our sequencing systems allow scientists to characterize genomes, transcriptomes, and epigenomes from any organism. Scientists use our technology in areas such as human biomedical research, plant and animal sciences, and microbiology and infectious disease studies. Become part of the new paradigm in long-read sequencing and help shape the future of genomic study by joining the Pacific Biosciences team. Pacific Biosciences is looking for an experienced electrical engineering leader to oversee the development and upkeep of the electronic subsystems for our next generation SMRT sequencing instruments. This person will coordinate a cross disciplinary electrical and FPGA engineering team that is architecting, developing and integrating complex and high-performance subsystems integral to our DNA sequencing products. This person will orchestrate hardware research and development activities related to low level embedded control, high performance sensor data capture and high-performance computing. This successful candidate must have excellent oral and written communication skills and be able to effectively interface with mechanical, optical, software and systems leaders within the department as well as cross departmental leaders in manufacturing and program management. Responsibilities Lead the design and development of the instrument electronics architecture. Work with stakeholders across the company to understand product needs and implement solutions that meet business goals for quality, schedule, and cost. Develop plans and timelines, work with program management to integrate plans into a larger program. Participate in crafting budget for area of responsibility. Transition deliverables to mass production in collaboration with manufacturing NPI. Collaborate with manufacturing on product sustaining activities Select and manage external technology development partners. Attract, develop, and retain an engaged electrical and FPGA engineering team. Requirement Bachelors and/or Masters in Electrical Engineering or related discipline with 10+ years of work experience. Possess an analytical mindset and experience with electronic and FPGA design. Experience managing and architecting complex high performance embedded systems. Demonstrated competency in electronics and computer architecture and transitioning products to manufacturing. Excellent interpersonal, verbal, and written communication skills. Excellent analytical and problem-solving skills, a strong team player, able to take initiative, detail-oriented, and able to work effectively as part of a management team. Thrives in a fast-paced environment, interacting with scientists and engineers from a variety of disciplines. All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
The Amgen Postdoctoral Program is committed to providing future scientists with an enriched environment to encourage innovation that will contribute to the generation of human therapeutics. We have an exciting new opening for a postdoctoral researcher in the Mammalian Expression group within Biologics Optimization at Amgen. The focus of this role is to generate novel mammalian expression systems utilizing state-of-the art genome editing and vectorology approaches. The goals are to enhance protein and vector variant library screening technologies by generating genome edited targeted integration CHO hosts and vectors; and, to improve the productivity and quality of difficult to express proteins such as bispecifics. This work may impact patients through the development of next generation biologics optimization screening approaches and novel manufacturing systems. The successful applicant will perform independent research within the context of a highly collaborative environment and with access to state-of-the-art technologies and resources, including molecular biology, mammalian expression, protein purification and analytics, and genomics. This fellowship will provide scientific training, the opportunity to publish, and exposure to the industrial biotechnology environment at Amgen. The assignment length is expected to be 3 years long. Basic Qualifications PhD. or Doctorate degree to be completed by March, 2020. Preferred Qualifications PhD in Molecular Biology, Cell Biology, Genomics, or Biochemistry. Proven expertise and publications using current gene-editing technologies, including CRISPR/Cas9 mediated genome engineering, as applied to mammalian and CHO systems. Experience in the generation and utilization of CHO targeted integration expression systems. Proficiencies in plasmid cloning, mammalian cell culturing, and genomics technologies. Record of independent critical thinking and the ability to design, execute, and interpret experiments, as exemplified by high quality peer-reviewed publications. Research expertise in genomics data analysis. Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do. Join Us If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
01/21/2021
Full time
The Amgen Postdoctoral Program is committed to providing future scientists with an enriched environment to encourage innovation that will contribute to the generation of human therapeutics. We have an exciting new opening for a postdoctoral researcher in the Mammalian Expression group within Biologics Optimization at Amgen. The focus of this role is to generate novel mammalian expression systems utilizing state-of-the art genome editing and vectorology approaches. The goals are to enhance protein and vector variant library screening technologies by generating genome edited targeted integration CHO hosts and vectors; and, to improve the productivity and quality of difficult to express proteins such as bispecifics. This work may impact patients through the development of next generation biologics optimization screening approaches and novel manufacturing systems. The successful applicant will perform independent research within the context of a highly collaborative environment and with access to state-of-the-art technologies and resources, including molecular biology, mammalian expression, protein purification and analytics, and genomics. This fellowship will provide scientific training, the opportunity to publish, and exposure to the industrial biotechnology environment at Amgen. The assignment length is expected to be 3 years long. Basic Qualifications PhD. or Doctorate degree to be completed by March, 2020. Preferred Qualifications PhD in Molecular Biology, Cell Biology, Genomics, or Biochemistry. Proven expertise and publications using current gene-editing technologies, including CRISPR/Cas9 mediated genome engineering, as applied to mammalian and CHO systems. Experience in the generation and utilization of CHO targeted integration expression systems. Proficiencies in plasmid cloning, mammalian cell culturing, and genomics technologies. Record of independent critical thinking and the ability to design, execute, and interpret experiments, as exemplified by high quality peer-reviewed publications. Research expertise in genomics data analysis. Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do. Join Us If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.