Principal Research Associate, Antibody Discovery

  • Omeros Corporation
  • Seattle, Washington
  • 01/16/2021
Full time

Job Description

Principal Research Associate, Antibody Discovery

In this role, the individual will perform multiple roles within the antibody discovery group at Omeros. The primary role will be to participate in the implementation of antibody discovery campaigns using a mouse hybridoma platform. Other roles will include developing and performing immunoassays and other techniques related to the screening, production, purification and characterization of antibodies and other proteins.

Good things are happening at Omeros!

Come join our Omeros Discovery Team!

Who is Omeros?

Omeros is a commercial-stage biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, complement-mediated diseases, disorders of the central nervous system and immune-related diseases, including cancers. In addition to its commercial product OMIDRIA (phenylephrine and ketorolac intraocular solution) 1%/0.3%, Omeros has multiple phase 3 and phase 2 clinical-stage development programs focused on complement-mediated disorders and substance abuse. Omeros also has a diverse group of preclinical programs including GPR174, a novel target in immuno-oncology that modulates a new cancer immunity axis recently discovered by Omeros. Small-molecule inhibitors of GPR174 are part of Omeros' proprietary G proteincoupled receptor (GPCR) platform through which it controls 54 new GPCR drug targets and their corresponding compounds. The company also exclusively possesses a novel antibody-generating platform.

What are your job responsibilities?

  • Participate in the planning and implementation of antibody discovery campaigns using a mouse hybridoma platform
  • Develop and perform immunoassays and biochemical or cellular assays in support of antibody discovery campaigns
  • Produce, purify and characterize antibodies and other proteins
What education and experience do you need?

  • College degree in Biology, Biochemistry, or a related life sciences field and 8+ years of relevant academic or industrial lab experience
  • Knowledge of immunization practices and strategies (such as dose schedules and adjuvants) that are used in hybridoma and polyclonal antibody development
  • Experience in handling animals (primarily mice) used for immunization and hybridoma development
  • Solid sterile cell culture experience, including generation and maintenance of stably and transiently transfected cell lines
  • In depth experience with generation, culturing and screening of hybridomas
  • Experience with assays to assess in vitro and in vivo pharmacology of biologics
  • Recombinant protein (especially antibody) purification experience
  • Expression and purification of antibodies and recombinant proteins experience
  • Immunoassays and other plate-based assay platforms experience
  • Experience with SDS-PAGE and other common laboratory methods of protein analysis
  • Planning and implementing experiments independently, preparing buffers and chemical solutions
  • Excellent organizational skills and be committed to keeping detailed, meticulous and comprehensive record keeping, including laboratory notebooks and electronic databases
  • Excellent written and verbal skills, strong analytical and problem-solving skills, and effective in communicating scientific ideas to the group
Behavioral Competencies Required:

  • Demonstrated ability to build and maintain positive relationships with management, peers, and subordinates
  • Integrity
Physical Demands Required:

  • Intermittent physical activity including bending, reaching, pushing, pulling, or lifting up to 40 lbs.
  • May encounter prolonged periods of sitting or standing
  • This position requires working around hazardous materials
If you have the experience, skills and knowledge we are seeking, we'd love to hear from you! This is an exciting opportunity for the right person!

Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

If you have the experience, skills and knowledge we are seeking, we'd love to hear from you! This is an exciting opportunity for the right person!Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to or contact Omeros, asking for Human Resources, at