We are seeking an experienced engineer to work on distributed AI/ML systems. This role involves working on collective operations - the fundamental operations that enable AI to scale across multiple accelerators & servers. Most of our stack is C/C++ and relatively low level, so solid knowledge of Linux, kernels, and performant code is important. Experience with embedded systems is valued, and experience with high-speed networking or HPC interconnects is valued highly. If you like solving hard problems, want to work with HPC and ML customers, iterate fast and deliver meaningful solutions at scale, then come join us! This truly is a role on the forefront of AI/ML, you'll be working on features for the largest clusters, with the largest customers, for the largest AI models. The org you would be joining is Annapurna Labs, an integral part of AWS and develops hardware and software components that are critical building blocks for EC2 infrastructure. Every instance in EC2 is running some type of hardware designed in Annapurna Labs. We specialize in designing software, systems and chips that optimize the AWS customer experience. A day in the life Annapurna Labs, a crucial part of AWS, is responsible for developing hardware and software components for EC2 infrastructure. Our team focuses on building networking solutions that for Machine Learning (ML) and High-Performance Computing (HPC) workloads on AWS. We have mixed discipline orgs, you'd be working side by side with infrastructure experts, hardware engineers, RTL engineers, scientists & architects. Our workforce spans the globe and is truly international, you'll find yourself working side by side with individuals from numerous countries. We take mentorship seriously, you can both expect senior mentorship and will be expected to mentor new and junior engineers. The pace is fast as we work on the latest advancements of AI/ML, but we take the time to bond as a team and enjoy the successes. We offer flexibility in working hours, and respect WLB as a core org tenet. The team enjoys working with numerous principal-level engineers and closely with directors, career growth opportunities are certainly available. This is a role where you will always be encouraged to keep learning, the AI/ML field is fast moving and constantly evolving. About the team Our team is dedicated to supporting new members. We have a broad mix of experience levels and tenures, and we're building an environment that celebrates knowledge-sharing and mentorship. Our senior members enjoy one-on-one mentoring and thorough, but kind, code reviews. We care about your career growth and strive to assign projects that help our team members develop your engineering expertise so you feel empowered to take on more complex tasks in the future. Diverse Experiences AWS values diverse experiences. Even if you do not meet all of the qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn't followed a traditional path, or includes alternative experiences, don't let it stop you from applying. About AWS Amazon Web Services (AWS) is the world's most comprehensive and broadly adopted cloud platform. We pioneered cloud computing and never stopped innovating - that's why customers from the most successful startups to Global 500 companies trust our robust suite of products and services to power their businesses. Inclusive Team Culture Here at AWS, it's in our nature to learn and be curious. Our employee-led affinity groups foster a culture of inclusion that empower us to be proud of our differences. Ongoing events and learning experiences, including our Conversations on Race and Ethnicity (CORE) and AmazeCon conferences, inspire us to never stop embracing our uniqueness. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why we strive for flexibility as part of our working culture. When we feel supported in the workplace and at home, there's nothing we can't achieve in the cloud. Mentorship & Career Growth We're continuously raising our performance bar as we strive to become Earth's Best Employer. That's why you'll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. BASIC QUALIFICATIONS - 5+ years of non-internship professional software development experience - 5+ years of programming with at least one software programming language experience - 5+ years of leading design or architecture (design patterns, reliability and scaling) of new and existing systems experience - 5+ years of full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations experience - Experience as a mentor, tech lead or leading an engineering team PREFERRED QUALIFICATIONS - Bachelor's degree in computer science or equivalent Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company's reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner. Our compensation reflects the cost of labor across several US geographic markets. The base pay for this position ranges from $151,300/year in our lowest geographic market up to $261,500/year in our highest geographic market. Pay is based on a number of factors including market location and may vary depending on job-related knowledge, skills, and experience. Amazon is a total compensation company. Dependent on the position offered, equity, sign-on payments, and other forms of compensation may be provided as part of a total compensation package, in addition to a full range of medical, financial, and/or other benefits. For more information, please visit . This position will remain posted until filled. Applicants should apply via our internal or external career site.
11/01/2025
Full time
We are seeking an experienced engineer to work on distributed AI/ML systems. This role involves working on collective operations - the fundamental operations that enable AI to scale across multiple accelerators & servers. Most of our stack is C/C++ and relatively low level, so solid knowledge of Linux, kernels, and performant code is important. Experience with embedded systems is valued, and experience with high-speed networking or HPC interconnects is valued highly. If you like solving hard problems, want to work with HPC and ML customers, iterate fast and deliver meaningful solutions at scale, then come join us! This truly is a role on the forefront of AI/ML, you'll be working on features for the largest clusters, with the largest customers, for the largest AI models. The org you would be joining is Annapurna Labs, an integral part of AWS and develops hardware and software components that are critical building blocks for EC2 infrastructure. Every instance in EC2 is running some type of hardware designed in Annapurna Labs. We specialize in designing software, systems and chips that optimize the AWS customer experience. A day in the life Annapurna Labs, a crucial part of AWS, is responsible for developing hardware and software components for EC2 infrastructure. Our team focuses on building networking solutions that for Machine Learning (ML) and High-Performance Computing (HPC) workloads on AWS. We have mixed discipline orgs, you'd be working side by side with infrastructure experts, hardware engineers, RTL engineers, scientists & architects. Our workforce spans the globe and is truly international, you'll find yourself working side by side with individuals from numerous countries. We take mentorship seriously, you can both expect senior mentorship and will be expected to mentor new and junior engineers. The pace is fast as we work on the latest advancements of AI/ML, but we take the time to bond as a team and enjoy the successes. We offer flexibility in working hours, and respect WLB as a core org tenet. The team enjoys working with numerous principal-level engineers and closely with directors, career growth opportunities are certainly available. This is a role where you will always be encouraged to keep learning, the AI/ML field is fast moving and constantly evolving. About the team Our team is dedicated to supporting new members. We have a broad mix of experience levels and tenures, and we're building an environment that celebrates knowledge-sharing and mentorship. Our senior members enjoy one-on-one mentoring and thorough, but kind, code reviews. We care about your career growth and strive to assign projects that help our team members develop your engineering expertise so you feel empowered to take on more complex tasks in the future. Diverse Experiences AWS values diverse experiences. Even if you do not meet all of the qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn't followed a traditional path, or includes alternative experiences, don't let it stop you from applying. About AWS Amazon Web Services (AWS) is the world's most comprehensive and broadly adopted cloud platform. We pioneered cloud computing and never stopped innovating - that's why customers from the most successful startups to Global 500 companies trust our robust suite of products and services to power their businesses. Inclusive Team Culture Here at AWS, it's in our nature to learn and be curious. Our employee-led affinity groups foster a culture of inclusion that empower us to be proud of our differences. Ongoing events and learning experiences, including our Conversations on Race and Ethnicity (CORE) and AmazeCon conferences, inspire us to never stop embracing our uniqueness. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why we strive for flexibility as part of our working culture. When we feel supported in the workplace and at home, there's nothing we can't achieve in the cloud. Mentorship & Career Growth We're continuously raising our performance bar as we strive to become Earth's Best Employer. That's why you'll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. BASIC QUALIFICATIONS - 5+ years of non-internship professional software development experience - 5+ years of programming with at least one software programming language experience - 5+ years of leading design or architecture (design patterns, reliability and scaling) of new and existing systems experience - 5+ years of full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations experience - Experience as a mentor, tech lead or leading an engineering team PREFERRED QUALIFICATIONS - Bachelor's degree in computer science or equivalent Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company's reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner. Our compensation reflects the cost of labor across several US geographic markets. The base pay for this position ranges from $151,300/year in our lowest geographic market up to $261,500/year in our highest geographic market. Pay is based on a number of factors including market location and may vary depending on job-related knowledge, skills, and experience. Amazon is a total compensation company. Dependent on the position offered, equity, sign-on payments, and other forms of compensation may be provided as part of a total compensation package, in addition to a full range of medical, financial, and/or other benefits. For more information, please visit . This position will remain posted until filled. Applicants should apply via our internal or external career site.
Vantive is a vital organ therapy company on a mission to extend lives and expand possibilities for patients and care teams everywhere. For 70 years, our team has driven meaningful innovations in kidney care. As we build on our legacy, we are deepening our commitment to elevating the dialysis experience through digital solutions and advanced services, while looking beyond kidney care and investing in transforming vital organ therapies. Greater flexibility and efficiency in therapy administration for care teams, and longer, fuller lives for patients- that is what Vantive aspires to deliver. We believe Vantive will not only build our leadership in the kidney care space, it will also offer meaningful work to those who join us. At Vantive, you will become part of a community of people who are focused, courageous and don't settle for the mediocre. Each of us is driven to help improve patients' lives worldwide. Join us in advancing our mission to extend lives and expand possibilities. Your Role Are you ready to take your engineering career to the next level? Look no further! Vantive is seeking a highly skilled Principal Engineer, Materials Scientist to join our exceptional Disposables R&D team in Plymouth. As a world-class leader in healthcare, Vantive is dedicated to improving the lives of millions of patients worldwide. This is a unique opportunity to be part of our ambitious mission and make a real impact. The Principal Engineer, Materials Scientist will apply specialized knowledge of materials and material processing to achieve a technical vision for research and design of containers and disposable products used in multiple Kidney care modalities. You will p rovide leadership to design and manufacturing teams directing extrusion, molding, material processing and design transfer. What you will be doing: Develop products/processes (materials, design, quality improvement, research techniques) incorporating multiple tasks in the disciplines of materials science and engineering for Renal products. Serve as the technical materials expert for design change programs ( new products, suppliers, materials, labeling, CAPA/NCR, cost reduction, remediation ). Produce pilot production runs of materials and sheeting for the use in the development process and to establish process capability. Study design and hands on support with polymeric materials characterization , blending and processing Identify , investigate, and solve complex engineering problems utilizing risk-based and customer focused approaches and engineering tools. ( e.g. dFMEA , Human Factors Engineering, statistical software, CAD). Coordinate and communicate the efforts of R&D in collaboration with g lobal cross-functional stakeholders. Schedule, budget, and lead engineering projects with minimal guidance. Adhere to design control procedures, general safety rules, company policies and procedures, FDA and international regulations and guidance . May supervise engine ers and/or technicians. May c ontribute to Vantive intellectual property through invention disclosures and patent applications. What you will bring: BS in Material Science or Engineering, Chemistry, Chemical Engineering or related science or engineering field . MS or PhD preferred. 10 + years of related experience in disposables medical product development. Advanced knowledge of chemistry, material science and general engineering principles related to the development of new plastic materials Advanced knowledge of plastic material processing including injection molding, extrusion, ultrasonic welding, UV/solvent bonding, and sterilization . K nowledge of FDA Design Controls and ISO 13485 Quality Management Systems desired. K nowledge of ANSI/AAMI/ISO 14971 Medical Devices - Application o f Risk Management t o Medical Devices desired Takes initiative with a high aptitude for learning, innovation, and implementing best practices and continuous improvements . Schedule, budget, and lead engineering projects with minimal guidance. Ability to train and coach others in area of technical expertise . S elf-directed, resourceful, and able to manage multiple priorities. Strong interpersonal, communication, collaboration and influencing skills. Vantive is committed to supporting the needs for flexibility in the workplace. We do so through our flexible workplace policy which includes a minimum of 3 days a week onsite. This policy provides the benefits of connecting and collaborating in-person in support of our Mission. We understand compensation is an important factor as you consider the next step in your career. At Vantive, we are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. The estimated base salary for this position is $104,000-130,000 annually. The estimated range is meant to reflect an anticipated salary range for the position. We may pay more or less than of the anticipated range based upon market data and other factors, all of which are subject to change. Individual pay is based on upon location, skills and expertise, experience, and other relevant factors. This position may also be eligible for discretionary bonuses, and/or long-term incentive. For questions about this, our pay philosophy, and available benefits, please speak to the recruiter if you decide to apply and are selected for an interview. US Benefits at Vantive This is where your well-being matters. Vantive offers comprehensive compensation and benefits packages for eligible roles. Our health and well-being benefits include medical, dental and vision coverage that start on day one, as well as insurance coverage for basic life, accident, short-term and long-term disability, and business travel accident insurance. Financial and retirement benefits include the Aon Pooled Employer Plan ("Aon PEP"), Vantive's 401(k) retirement savings plan, to help you prepare for your future. The Aon PEP is designed to help improve retirement outcomes by providing retirement resources more efficiently. The plan offers a robust set of investment options, financial education, and a suite of resources to support your retirement goals. We also offer Flexible Spending Accounts, educational assistance programs, and time-off benefits such as paid holidays, paid time off ranging from 20 to 35 days based on length of service, family and medical leaves of absence, and paid parental leave. Additional benefits include commuting benefits, the Employee Discount Program, the Employee Assistance Program (EAP), and childcare benefits. Join us and enjoy the competitive compensation and benefits we offer to our employees. For additional information regarding Vantive's US Benefits, please speak with your recruiter or visit our Benefits site: Benefits Vantive Equal Employment Opportunity Vantive is an equal opportunity employer. Vantive evaluates qualified applicants without regard to race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, protected veteran status, disability/handicap status or any other legally protected characteristic. Know Your Rights: Workplace Discrimination is Illegal Reasonable Accommodation Vantive is committed to working with and providing reasonable accommodations to individuals with disabilities globally. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application or interview process, please click on the link here and let us know the nature of your request along with your contact information. Form Link Recruitment Fraud Notice Vantive has discovered incidents of employment scams, where fraudulent parties pose as Vantive employees, recruiters, or other agents, and engage with online job seekers in an attempt to steal personal and/or financial information. To learn how you can protect yourself, review our Recruitment Fraud Notice .
10/07/2025
Full time
Vantive is a vital organ therapy company on a mission to extend lives and expand possibilities for patients and care teams everywhere. For 70 years, our team has driven meaningful innovations in kidney care. As we build on our legacy, we are deepening our commitment to elevating the dialysis experience through digital solutions and advanced services, while looking beyond kidney care and investing in transforming vital organ therapies. Greater flexibility and efficiency in therapy administration for care teams, and longer, fuller lives for patients- that is what Vantive aspires to deliver. We believe Vantive will not only build our leadership in the kidney care space, it will also offer meaningful work to those who join us. At Vantive, you will become part of a community of people who are focused, courageous and don't settle for the mediocre. Each of us is driven to help improve patients' lives worldwide. Join us in advancing our mission to extend lives and expand possibilities. Your Role Are you ready to take your engineering career to the next level? Look no further! Vantive is seeking a highly skilled Principal Engineer, Materials Scientist to join our exceptional Disposables R&D team in Plymouth. As a world-class leader in healthcare, Vantive is dedicated to improving the lives of millions of patients worldwide. This is a unique opportunity to be part of our ambitious mission and make a real impact. The Principal Engineer, Materials Scientist will apply specialized knowledge of materials and material processing to achieve a technical vision for research and design of containers and disposable products used in multiple Kidney care modalities. You will p rovide leadership to design and manufacturing teams directing extrusion, molding, material processing and design transfer. What you will be doing: Develop products/processes (materials, design, quality improvement, research techniques) incorporating multiple tasks in the disciplines of materials science and engineering for Renal products. Serve as the technical materials expert for design change programs ( new products, suppliers, materials, labeling, CAPA/NCR, cost reduction, remediation ). Produce pilot production runs of materials and sheeting for the use in the development process and to establish process capability. Study design and hands on support with polymeric materials characterization , blending and processing Identify , investigate, and solve complex engineering problems utilizing risk-based and customer focused approaches and engineering tools. ( e.g. dFMEA , Human Factors Engineering, statistical software, CAD). Coordinate and communicate the efforts of R&D in collaboration with g lobal cross-functional stakeholders. Schedule, budget, and lead engineering projects with minimal guidance. Adhere to design control procedures, general safety rules, company policies and procedures, FDA and international regulations and guidance . May supervise engine ers and/or technicians. May c ontribute to Vantive intellectual property through invention disclosures and patent applications. What you will bring: BS in Material Science or Engineering, Chemistry, Chemical Engineering or related science or engineering field . MS or PhD preferred. 10 + years of related experience in disposables medical product development. Advanced knowledge of chemistry, material science and general engineering principles related to the development of new plastic materials Advanced knowledge of plastic material processing including injection molding, extrusion, ultrasonic welding, UV/solvent bonding, and sterilization . K nowledge of FDA Design Controls and ISO 13485 Quality Management Systems desired. K nowledge of ANSI/AAMI/ISO 14971 Medical Devices - Application o f Risk Management t o Medical Devices desired Takes initiative with a high aptitude for learning, innovation, and implementing best practices and continuous improvements . Schedule, budget, and lead engineering projects with minimal guidance. Ability to train and coach others in area of technical expertise . S elf-directed, resourceful, and able to manage multiple priorities. Strong interpersonal, communication, collaboration and influencing skills. Vantive is committed to supporting the needs for flexibility in the workplace. We do so through our flexible workplace policy which includes a minimum of 3 days a week onsite. This policy provides the benefits of connecting and collaborating in-person in support of our Mission. We understand compensation is an important factor as you consider the next step in your career. At Vantive, we are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. The estimated base salary for this position is $104,000-130,000 annually. The estimated range is meant to reflect an anticipated salary range for the position. We may pay more or less than of the anticipated range based upon market data and other factors, all of which are subject to change. Individual pay is based on upon location, skills and expertise, experience, and other relevant factors. This position may also be eligible for discretionary bonuses, and/or long-term incentive. For questions about this, our pay philosophy, and available benefits, please speak to the recruiter if you decide to apply and are selected for an interview. US Benefits at Vantive This is where your well-being matters. Vantive offers comprehensive compensation and benefits packages for eligible roles. Our health and well-being benefits include medical, dental and vision coverage that start on day one, as well as insurance coverage for basic life, accident, short-term and long-term disability, and business travel accident insurance. Financial and retirement benefits include the Aon Pooled Employer Plan ("Aon PEP"), Vantive's 401(k) retirement savings plan, to help you prepare for your future. The Aon PEP is designed to help improve retirement outcomes by providing retirement resources more efficiently. The plan offers a robust set of investment options, financial education, and a suite of resources to support your retirement goals. We also offer Flexible Spending Accounts, educational assistance programs, and time-off benefits such as paid holidays, paid time off ranging from 20 to 35 days based on length of service, family and medical leaves of absence, and paid parental leave. Additional benefits include commuting benefits, the Employee Discount Program, the Employee Assistance Program (EAP), and childcare benefits. Join us and enjoy the competitive compensation and benefits we offer to our employees. For additional information regarding Vantive's US Benefits, please speak with your recruiter or visit our Benefits site: Benefits Vantive Equal Employment Opportunity Vantive is an equal opportunity employer. Vantive evaluates qualified applicants without regard to race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, protected veteran status, disability/handicap status or any other legally protected characteristic. Know Your Rights: Workplace Discrimination is Illegal Reasonable Accommodation Vantive is committed to working with and providing reasonable accommodations to individuals with disabilities globally. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application or interview process, please click on the link here and let us know the nature of your request along with your contact information. Form Link Recruitment Fraud Notice Vantive has discovered incidents of employment scams, where fraudulent parties pose as Vantive employees, recruiters, or other agents, and engage with online job seekers in an attempt to steal personal and/or financial information. To learn how you can protect yourself, review our Recruitment Fraud Notice .
At Boston Fusion, we recognize diversity is the catalyst for limitless creativity. As a Principal Research Scientist for Boston Fusion, you will have the opportunity to utilize your knowledge of scientific research and software engineering best practices to contribute and drive research efforts in development of systems core to the success of future Intelligence, Surveillance, and Reconnaissance (ISR) activities. This role will lead technical teams as a Principal Investigator, lead and contribute to proposal efforts, and collaborate with project teams to solve complex technical problems that support national security. Every day, we go above and beyond to solve complex problems, making a difference for our nation. We do this by bringing together smart, curious people with diverse life experiences who collaborate creatively to achieve innovative technological breakthroughs. We are proudly building a work environment where you can bring your authentic self to work. Due to the nature of our project work, we can only consider candidates with a current US Citizenship. Day to Day Responsibilities Lead proposal/business capture teams to shape, write and review proposals Interface with customers, including travel, to shape marketing efforts and effectively communicate technical results Investigate fundamental topics in a scientific field such as signal processing, artificial intelligence, machine learning, data science, physics and/or math Lead teams of two or more Scientists, Engineers, and Programmers, including identifying, assigning, and completing research and development tasks appropriate to each member of the team Provide strategic leadership role in working with a project / proposal team to identify the research approach, hypotheses to be tested, and program milestones to achieve all program objectives Facilitate collaboration in large, complex teams to ensure resulting technology (algorithms, software, frameworks) achieves all research objectives Select, improve, or design computational models Identify relevant research approaches, hypotheses to be tested, and program milestones to achieve all program objectives with project and/or proposal teams Provide scientific, technical and software design support to projects and proposals Design statistically valid experiments to test and validate resulting computational models Provide leadership and guidance in the analysis of results of the experiments using sound scientific principles Design experiments to test and validate computational models Establish and maintain a professional rapport with all project stakeholders (internal and external) Additional project and proposal duties as assigned Additional Responsibilities Occasional travel to attend and present at customer meetings and essential industry conferences Prepare technical briefing materials/summarize technical work and progress of projects Collaborate with company leadership and senior technical staff to conduct proposal research and proposal writing Publish technical reports based on original or improved algorithms created to solve the application challenges Maintain high standards at work, continuously looking for solutions to improve processes and products Develop, maintain, and strengthen partnerships with others inside and outside the organization to achieve Boston Fusion business goals Demonstrate personal accountability, effective work habits, integrity, and ethical behavior that align with Boston Fusion corporate values May perform other duties as required This Job is Right for You if you Have: Masters degree in cognitive sciences, engineering, mathematics, physics, or related field, with 13+ years of experience; PhD with 10+ years of experience Excellent analytical and problem-solving skills Ability to prioritize and manage time effectively Excellent communication, writing and presentation skills Ability to work both collaboratively and independently Demonstrates strong competency in every category and a mastery of at least one category Demonstrated competency in AI/ML, and/or signal processing and/or human-machine systems, and/or cognitive sciences, or social sciences, and/or computer vision, or other technical discipline Experience implementing modeling and analysis techniques, including machine learning and probabilistic modelling etc Understanding of mathematical principles which underlie these modeling methods Experience in implementing algorithms in standard programming languages such as Python, Java, C++ Experience in using sound software development techniques, e.g., testing, documentation, source control Preferred Technical Qualifications Classical applied probabilistic, mathematical, and/or artificial intelligence methods (planning, searching, logic, uncertain knowledge, probabilistic reasoning, natural language processing) Radar signal processing techniques Machine learning frameworks (e.g., Scikit-learn, Tensorflow, PyTorch, Keras) and concepts (e.g., supervised, unsupervised, active, and reinforcement learning; neural networks; generative, discriminative models) Preferred Domain Knowledge Experience applying technology to US Department of Defense and/or Intelligence Community problems, including but not limited to the following: intelligence analysis, command and control, logistics, ISR, information operations, missile defense, operations in the cyber, space, or maritime domains 8+ years of experience in a research leadership role Work Authorization/Security Clearance Requirements U.S. citizenship (REQUIRED) and DoD security clearance (PREFERRED) PI30c0e71046ca-7946
10/02/2025
Full time
At Boston Fusion, we recognize diversity is the catalyst for limitless creativity. As a Principal Research Scientist for Boston Fusion, you will have the opportunity to utilize your knowledge of scientific research and software engineering best practices to contribute and drive research efforts in development of systems core to the success of future Intelligence, Surveillance, and Reconnaissance (ISR) activities. This role will lead technical teams as a Principal Investigator, lead and contribute to proposal efforts, and collaborate with project teams to solve complex technical problems that support national security. Every day, we go above and beyond to solve complex problems, making a difference for our nation. We do this by bringing together smart, curious people with diverse life experiences who collaborate creatively to achieve innovative technological breakthroughs. We are proudly building a work environment where you can bring your authentic self to work. Due to the nature of our project work, we can only consider candidates with a current US Citizenship. Day to Day Responsibilities Lead proposal/business capture teams to shape, write and review proposals Interface with customers, including travel, to shape marketing efforts and effectively communicate technical results Investigate fundamental topics in a scientific field such as signal processing, artificial intelligence, machine learning, data science, physics and/or math Lead teams of two or more Scientists, Engineers, and Programmers, including identifying, assigning, and completing research and development tasks appropriate to each member of the team Provide strategic leadership role in working with a project / proposal team to identify the research approach, hypotheses to be tested, and program milestones to achieve all program objectives Facilitate collaboration in large, complex teams to ensure resulting technology (algorithms, software, frameworks) achieves all research objectives Select, improve, or design computational models Identify relevant research approaches, hypotheses to be tested, and program milestones to achieve all program objectives with project and/or proposal teams Provide scientific, technical and software design support to projects and proposals Design statistically valid experiments to test and validate resulting computational models Provide leadership and guidance in the analysis of results of the experiments using sound scientific principles Design experiments to test and validate computational models Establish and maintain a professional rapport with all project stakeholders (internal and external) Additional project and proposal duties as assigned Additional Responsibilities Occasional travel to attend and present at customer meetings and essential industry conferences Prepare technical briefing materials/summarize technical work and progress of projects Collaborate with company leadership and senior technical staff to conduct proposal research and proposal writing Publish technical reports based on original or improved algorithms created to solve the application challenges Maintain high standards at work, continuously looking for solutions to improve processes and products Develop, maintain, and strengthen partnerships with others inside and outside the organization to achieve Boston Fusion business goals Demonstrate personal accountability, effective work habits, integrity, and ethical behavior that align with Boston Fusion corporate values May perform other duties as required This Job is Right for You if you Have: Masters degree in cognitive sciences, engineering, mathematics, physics, or related field, with 13+ years of experience; PhD with 10+ years of experience Excellent analytical and problem-solving skills Ability to prioritize and manage time effectively Excellent communication, writing and presentation skills Ability to work both collaboratively and independently Demonstrates strong competency in every category and a mastery of at least one category Demonstrated competency in AI/ML, and/or signal processing and/or human-machine systems, and/or cognitive sciences, or social sciences, and/or computer vision, or other technical discipline Experience implementing modeling and analysis techniques, including machine learning and probabilistic modelling etc Understanding of mathematical principles which underlie these modeling methods Experience in implementing algorithms in standard programming languages such as Python, Java, C++ Experience in using sound software development techniques, e.g., testing, documentation, source control Preferred Technical Qualifications Classical applied probabilistic, mathematical, and/or artificial intelligence methods (planning, searching, logic, uncertain knowledge, probabilistic reasoning, natural language processing) Radar signal processing techniques Machine learning frameworks (e.g., Scikit-learn, Tensorflow, PyTorch, Keras) and concepts (e.g., supervised, unsupervised, active, and reinforcement learning; neural networks; generative, discriminative models) Preferred Domain Knowledge Experience applying technology to US Department of Defense and/or Intelligence Community problems, including but not limited to the following: intelligence analysis, command and control, logistics, ISR, information operations, missile defense, operations in the cyber, space, or maritime domains 8+ years of experience in a research leadership role Work Authorization/Security Clearance Requirements U.S. citizenship (REQUIRED) and DoD security clearance (PREFERRED) PI30c0e71046ca-7946
We are seeking an experienced engineer to work on distributed AI/ML systems. This role involves working on collective operations - the fundamental operations that enable AI to scale across multiple accelerators & servers. Most of our stack is C/C++ and relatively low level, so solid knowledge of Linux, kernels, and performant code is important. Experience with embedded systems is valued, and experience with high-speed networking or HPC interconnects is valued highly. If you like solving hard problems, want to work with HPC and ML customers, iterate fast and deliver meaningful solutions at scale, then come join us! This truly is a role on the forefront of AI/ML, you'll be working on features for the largest clusters, with the largest customers, for the largest AI models. The org you would be joining is Annapurna Labs, an integral part of AWS and develops hardware and software components that are critical building blocks for EC2 infrastructure. Every instance in EC2 is running some type of hardware designed in Annapurna Labs. We specialize in designing software, systems and chips that optimize the AWS customer experience. A day in the life Annapurna Labs, a crucial part of AWS, is responsible for developing hardware and software components for EC2 infrastructure. Our team focuses on building networking solutions that for Machine Learning (ML) and High-Performance Computing (HPC) workloads on AWS. We have mixed discipline orgs, you'd be working side by side with infrastructure experts, hardware engineers, RTL engineers, scientists & architects. Our workforce spans the globe and is truly international, you'll find yourself working side by side with individuals from numerous countries. We take mentorship seriously, you can both expect senior mentorship and will be expected to mentor new and junior engineers. The pace is fast as we work on the latest advancements of AI/ML, but we take the time to bond as a team and enjoy the successes. We offer flexibility in working hours, and respect WLB as a core org tenet. The team enjoys working with numerous principal-level engineers and closely with directors, career growth opportunities are certainly available. This is a role where you will always be encouraged to keep learning, the AI/ML field is fast moving and constantly evolving. About the team Our team is dedicated to supporting new members. We have a broad mix of experience levels and tenures, and we're building an environment that celebrates knowledge-sharing and mentorship. Our senior members enjoy one-on-one mentoring and thorough, but kind, code reviews. We care about your career growth and strive to assign projects that help our team members develop your engineering expertise so you feel empowered to take on more complex tasks in the future. Diverse Experiences AWS values diverse experiences. Even if you do not meet all of the qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn't followed a traditional path, or includes alternative experiences, don't let it stop you from applying. About AWS Amazon Web Services (AWS) is the world's most comprehensive and broadly adopted cloud platform. We pioneered cloud computing and never stopped innovating - that's why customers from the most successful startups to Global 500 companies trust our robust suite of products and services to power their businesses. Inclusive Team Culture Here at AWS, it's in our nature to learn and be curious. Our employee-led affinity groups foster a culture of inclusion that empower us to be proud of our differences. Ongoing events and learning experiences, including our Conversations on Race and Ethnicity (CORE) and AmazeCon conferences, inspire us to never stop embracing our uniqueness. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why we strive for flexibility as part of our working culture. When we feel supported in the workplace and at home, there's nothing we can't achieve in the cloud. Mentorship & Career Growth We're continuously raising our performance bar as we strive to become Earth's Best Employer. That's why you'll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. BASIC QUALIFICATIONS - 5+ years of non-internship professional software development experience - 5+ years of programming with at least one software programming language experience - 5+ years of leading design or architecture (design patterns, reliability and scaling) of new and existing systems experience - 5+ years of full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations experience - Experience as a mentor, tech lead or leading an engineering team PREFERRED QUALIFICATIONS - Bachelor's degree in computer science or equivalent Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company's reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner. Our compensation reflects the cost of labor across several US geographic markets. The base pay for this position ranges from $151,300/year in our lowest geographic market up to $261,500/year in our highest geographic market. Pay is based on a number of factors including market location and may vary depending on job-related knowledge, skills, and experience. Amazon is a total compensation company. Dependent on the position offered, equity, sign-on payments, and other forms of compensation may be provided as part of a total compensation package, in addition to a full range of medical, financial, and/or other benefits. For more information, please visit . This position will remain posted until filled. Applicants should apply via our internal or external career site.
10/01/2025
Full time
We are seeking an experienced engineer to work on distributed AI/ML systems. This role involves working on collective operations - the fundamental operations that enable AI to scale across multiple accelerators & servers. Most of our stack is C/C++ and relatively low level, so solid knowledge of Linux, kernels, and performant code is important. Experience with embedded systems is valued, and experience with high-speed networking or HPC interconnects is valued highly. If you like solving hard problems, want to work with HPC and ML customers, iterate fast and deliver meaningful solutions at scale, then come join us! This truly is a role on the forefront of AI/ML, you'll be working on features for the largest clusters, with the largest customers, for the largest AI models. The org you would be joining is Annapurna Labs, an integral part of AWS and develops hardware and software components that are critical building blocks for EC2 infrastructure. Every instance in EC2 is running some type of hardware designed in Annapurna Labs. We specialize in designing software, systems and chips that optimize the AWS customer experience. A day in the life Annapurna Labs, a crucial part of AWS, is responsible for developing hardware and software components for EC2 infrastructure. Our team focuses on building networking solutions that for Machine Learning (ML) and High-Performance Computing (HPC) workloads on AWS. We have mixed discipline orgs, you'd be working side by side with infrastructure experts, hardware engineers, RTL engineers, scientists & architects. Our workforce spans the globe and is truly international, you'll find yourself working side by side with individuals from numerous countries. We take mentorship seriously, you can both expect senior mentorship and will be expected to mentor new and junior engineers. The pace is fast as we work on the latest advancements of AI/ML, but we take the time to bond as a team and enjoy the successes. We offer flexibility in working hours, and respect WLB as a core org tenet. The team enjoys working with numerous principal-level engineers and closely with directors, career growth opportunities are certainly available. This is a role where you will always be encouraged to keep learning, the AI/ML field is fast moving and constantly evolving. About the team Our team is dedicated to supporting new members. We have a broad mix of experience levels and tenures, and we're building an environment that celebrates knowledge-sharing and mentorship. Our senior members enjoy one-on-one mentoring and thorough, but kind, code reviews. We care about your career growth and strive to assign projects that help our team members develop your engineering expertise so you feel empowered to take on more complex tasks in the future. Diverse Experiences AWS values diverse experiences. Even if you do not meet all of the qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn't followed a traditional path, or includes alternative experiences, don't let it stop you from applying. About AWS Amazon Web Services (AWS) is the world's most comprehensive and broadly adopted cloud platform. We pioneered cloud computing and never stopped innovating - that's why customers from the most successful startups to Global 500 companies trust our robust suite of products and services to power their businesses. Inclusive Team Culture Here at AWS, it's in our nature to learn and be curious. Our employee-led affinity groups foster a culture of inclusion that empower us to be proud of our differences. Ongoing events and learning experiences, including our Conversations on Race and Ethnicity (CORE) and AmazeCon conferences, inspire us to never stop embracing our uniqueness. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why we strive for flexibility as part of our working culture. When we feel supported in the workplace and at home, there's nothing we can't achieve in the cloud. Mentorship & Career Growth We're continuously raising our performance bar as we strive to become Earth's Best Employer. That's why you'll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. BASIC QUALIFICATIONS - 5+ years of non-internship professional software development experience - 5+ years of programming with at least one software programming language experience - 5+ years of leading design or architecture (design patterns, reliability and scaling) of new and existing systems experience - 5+ years of full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations experience - Experience as a mentor, tech lead or leading an engineering team PREFERRED QUALIFICATIONS - Bachelor's degree in computer science or equivalent Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company's reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner. Our compensation reflects the cost of labor across several US geographic markets. The base pay for this position ranges from $151,300/year in our lowest geographic market up to $261,500/year in our highest geographic market. Pay is based on a number of factors including market location and may vary depending on job-related knowledge, skills, and experience. Amazon is a total compensation company. Dependent on the position offered, equity, sign-on payments, and other forms of compensation may be provided as part of a total compensation package, in addition to a full range of medical, financial, and/or other benefits. For more information, please visit . This position will remain posted until filled. Applicants should apply via our internal or external career site.
JOB PURPOSE Sana is seeking an exceptional Senior Leader to join our dynamic and growing team supporting CMC development of novel gene and cell therapy drug substances and products. The Senior Director of Process & Platform Operations is a key leadership position within Sana Technical Operations as we prepare to advance a pipeline of next-generation gene and cell therapy products to the clinic. The role will lead and build a team of production associates, engineers and scientists to provide technical leadership to establish operations for production and supply of material from research through Phase 1 GMP for novel gene therapy (viral vector) products. The team, led by this role, will establish efficient production operations to supply early research material supply, critical materials (GLP tox), and enable GMP supply by leading tech transfer to GMP manufacturing. The role has technical accountability and oversight for supply of materials from internal or external (CMO) GMP facilities, partnering with process development, analytical, and GMP manufacturing teams. The role will engage in Sana's enterprise-level manufacturing and supply chain planning, including the build out of internal GMP capabilities and external supply chain networks. In this capacity, the Leader will contribute to line-of-sight for life cycle management, with focus on process/technology improvements to the platform and assessment of product comparability. With a strong focus on both technical and operational excellence, this senior hands-on managerial position will play a leading role in shaping core production technology platforms at Sana and the advancement of therapeutic gene therapy candidates from Research into the clinic. This role represents an exciting and unique opportunity to shape the early CMC development paradigm for advanced therapies. DUTIES AND RESPONSIBILITIES The leader will oversee activities in support of early supply of quality research materials to guide pre-clinical candidate selection. With a mindset toward accelerating development, the leader will embrace both science and manufacturability to define and operationalize efficient production platforms for material supply across the early development horizon from candidate selection through to Phase 1 IND. The leader in this role will manage an operations team to supply early research, pilot scale supply and GLP study material supply, tech transfer and process establishment in GMP. The leader will participate with process and analytical development in early process characterization with an eye toward de-risking and troubleshooting production operations, use of scaledown models, and new manufacturing technology exploration. The role will be a member of the Manufacturing network leadership team and will contribute to and influence gene therapy manufacturing and network strategies, and standards for both drug substance and drug product production. The role will work closely with Process & Analytical Development, Quality, External Manufacturing, Supply Chain and CMC/product lifecycle teams to advance our pipeline and establish a robust development network for new products. The role will be viewed as a technical thought leader internally and externally in manufacturing viral vectors and complex biologics. The successful candidate will have industrial experience managing a process development team for biologics/vaccines (and/or preferably gene/cell therapy) and manufacturing operations, have a passion for delivering results and making an impact, an interest in technology and commitment to learning, and be an extraordinary collaborator in a dynamic setting. The ideal leader will shape strategy, build the capability, drive for operational excellence and continuous improvement, and manage a high-performing and growing team. Responsibilities: Establish scientifically-sound and operationally-efficient production workflows for supply of quality research-grade viral vectors for early research studies. Oversee a research production capability to support production of novel viral vector compositions for research customers, perform early optimization & manufacturability assessments, manage a lean industrial workflow to supply small-volume and high-quality vectors in line with business/customer expectations of turnaround time and capacity. Establish the requirements for the clinical manufacturing process for viral vector and ensure application of these requirements throughout the product life cycle. Leveraging a platform mindset to achieve speed and efficiency, establish processes at scale and define an approach for rapid introduction of new candidates. Be accountable for technical success of process operations in the supply of GLP and GMP material. Identify opportunities to shape both the technology platform and manufacturing operations to build a platform within Sana to increase speed, gain efficiency, increase probability of success of supply, reduce cost, and ensure quality in meeting program deliverables across the Sana portfolio of programs. As with other advanced therapies, critical attention to raw materials is a key consideration. Transfer processes developed to internal/external manufacturing sites. This includes ensuring clear definition of the clinical manufacturing control strategy and associated enabling documents/validation or supporting technical studies. Advise on developmental studies needed to ensure successful transfer and de-risking of clinical operations. Engage with Process & Analytical Development to ensure sound process qualification, control and comparability strategies are in place to support the programs. Review/author technical sections of major regulatory documents and contribute to the overall CMC strategy for vector technologies. Participate in the CMO selection process by evaluating CMO capabilities against technical requirements. Provide technical support of the CMOs for deviation management, lot disposition, batch record reviews to ensure that technical issues stay off the critical path for reliable supply. Participate in appropriate internal and joint CMO governance meetings (ex, joint steering committees). Ensure mitigation plans for significant technical risks at the CMOs or key raw material suppliers Hire and manage a team of scientists to define, operationalize, and maintain production workflows. Contribute to build-out of early product and process insights. With a focus on technical excellence, the individual will oversee production activities and their: implementation, performance, troubleshooting, and trending. With a focus on operational excellence, the individual will oversee the design, delivery, and continuous improvement of sample and analytical data workflows to address the needs of the business from the standpoint of: turnaround time, testing capacity, quality, and cost. Participate in establishment of drug substance and drug product specifications and provide technical leadership in review of content for regulatory interactions. QUALIFICATIONS Basic Qualifications Bachelors plus 12+ yrs or equivalent combination of education and work experience; expert knowledge of bioprocess principals and practice; a technical and people leader with experience managing department(s) with mid-level and senior employees. Experience with the following cell culture, purification, chromatography, clarification technologies, tangential flow and normal filtration, aseptic processing and drug product, process automation, high-throughput process development, automated liquid handling, electronic notebooks. Prior experience leading a team in Process Development, pilot scale production, tech transfer, and/or GMP manufacturing is important for success in the position. Must have exceptional organizational skills, preferably with advanced practical experience (+/-certification) in operational excellence or the management of complex workflows using Lean or Six Sigma. Solid understanding of relevant regulatory agency guidance such as FDA, ICH and EMA and hand-on experience. Ability to work in a fast-paced growth environment, and to prioritize work from multiple projects. Demonstrates a respect for others and is open to new/different ideas. Excellent written and verbal communication skills. Preferred Qualifications Bachelors plus 15 yrs or equivalent combination of education and work experience; expert knowledge of principals and concepts and is a thought leader; has experience managing department(s) with senior employees. Organizational leader with experience managing a team of direct (and indirect) reports in technical development of CMC (analytical, process, or formulation) packages for IND/CTA submission. Demonstrated track record, broad experience, and demonstrated success in process development and operations for complex biological products.
01/27/2021
Full time
JOB PURPOSE Sana is seeking an exceptional Senior Leader to join our dynamic and growing team supporting CMC development of novel gene and cell therapy drug substances and products. The Senior Director of Process & Platform Operations is a key leadership position within Sana Technical Operations as we prepare to advance a pipeline of next-generation gene and cell therapy products to the clinic. The role will lead and build a team of production associates, engineers and scientists to provide technical leadership to establish operations for production and supply of material from research through Phase 1 GMP for novel gene therapy (viral vector) products. The team, led by this role, will establish efficient production operations to supply early research material supply, critical materials (GLP tox), and enable GMP supply by leading tech transfer to GMP manufacturing. The role has technical accountability and oversight for supply of materials from internal or external (CMO) GMP facilities, partnering with process development, analytical, and GMP manufacturing teams. The role will engage in Sana's enterprise-level manufacturing and supply chain planning, including the build out of internal GMP capabilities and external supply chain networks. In this capacity, the Leader will contribute to line-of-sight for life cycle management, with focus on process/technology improvements to the platform and assessment of product comparability. With a strong focus on both technical and operational excellence, this senior hands-on managerial position will play a leading role in shaping core production technology platforms at Sana and the advancement of therapeutic gene therapy candidates from Research into the clinic. This role represents an exciting and unique opportunity to shape the early CMC development paradigm for advanced therapies. DUTIES AND RESPONSIBILITIES The leader will oversee activities in support of early supply of quality research materials to guide pre-clinical candidate selection. With a mindset toward accelerating development, the leader will embrace both science and manufacturability to define and operationalize efficient production platforms for material supply across the early development horizon from candidate selection through to Phase 1 IND. The leader in this role will manage an operations team to supply early research, pilot scale supply and GLP study material supply, tech transfer and process establishment in GMP. The leader will participate with process and analytical development in early process characterization with an eye toward de-risking and troubleshooting production operations, use of scaledown models, and new manufacturing technology exploration. The role will be a member of the Manufacturing network leadership team and will contribute to and influence gene therapy manufacturing and network strategies, and standards for both drug substance and drug product production. The role will work closely with Process & Analytical Development, Quality, External Manufacturing, Supply Chain and CMC/product lifecycle teams to advance our pipeline and establish a robust development network for new products. The role will be viewed as a technical thought leader internally and externally in manufacturing viral vectors and complex biologics. The successful candidate will have industrial experience managing a process development team for biologics/vaccines (and/or preferably gene/cell therapy) and manufacturing operations, have a passion for delivering results and making an impact, an interest in technology and commitment to learning, and be an extraordinary collaborator in a dynamic setting. The ideal leader will shape strategy, build the capability, drive for operational excellence and continuous improvement, and manage a high-performing and growing team. Responsibilities: Establish scientifically-sound and operationally-efficient production workflows for supply of quality research-grade viral vectors for early research studies. Oversee a research production capability to support production of novel viral vector compositions for research customers, perform early optimization & manufacturability assessments, manage a lean industrial workflow to supply small-volume and high-quality vectors in line with business/customer expectations of turnaround time and capacity. Establish the requirements for the clinical manufacturing process for viral vector and ensure application of these requirements throughout the product life cycle. Leveraging a platform mindset to achieve speed and efficiency, establish processes at scale and define an approach for rapid introduction of new candidates. Be accountable for technical success of process operations in the supply of GLP and GMP material. Identify opportunities to shape both the technology platform and manufacturing operations to build a platform within Sana to increase speed, gain efficiency, increase probability of success of supply, reduce cost, and ensure quality in meeting program deliverables across the Sana portfolio of programs. As with other advanced therapies, critical attention to raw materials is a key consideration. Transfer processes developed to internal/external manufacturing sites. This includes ensuring clear definition of the clinical manufacturing control strategy and associated enabling documents/validation or supporting technical studies. Advise on developmental studies needed to ensure successful transfer and de-risking of clinical operations. Engage with Process & Analytical Development to ensure sound process qualification, control and comparability strategies are in place to support the programs. Review/author technical sections of major regulatory documents and contribute to the overall CMC strategy for vector technologies. Participate in the CMO selection process by evaluating CMO capabilities against technical requirements. Provide technical support of the CMOs for deviation management, lot disposition, batch record reviews to ensure that technical issues stay off the critical path for reliable supply. Participate in appropriate internal and joint CMO governance meetings (ex, joint steering committees). Ensure mitigation plans for significant technical risks at the CMOs or key raw material suppliers Hire and manage a team of scientists to define, operationalize, and maintain production workflows. Contribute to build-out of early product and process insights. With a focus on technical excellence, the individual will oversee production activities and their: implementation, performance, troubleshooting, and trending. With a focus on operational excellence, the individual will oversee the design, delivery, and continuous improvement of sample and analytical data workflows to address the needs of the business from the standpoint of: turnaround time, testing capacity, quality, and cost. Participate in establishment of drug substance and drug product specifications and provide technical leadership in review of content for regulatory interactions. QUALIFICATIONS Basic Qualifications Bachelors plus 12+ yrs or equivalent combination of education and work experience; expert knowledge of bioprocess principals and practice; a technical and people leader with experience managing department(s) with mid-level and senior employees. Experience with the following cell culture, purification, chromatography, clarification technologies, tangential flow and normal filtration, aseptic processing and drug product, process automation, high-throughput process development, automated liquid handling, electronic notebooks. Prior experience leading a team in Process Development, pilot scale production, tech transfer, and/or GMP manufacturing is important for success in the position. Must have exceptional organizational skills, preferably with advanced practical experience (+/-certification) in operational excellence or the management of complex workflows using Lean or Six Sigma. Solid understanding of relevant regulatory agency guidance such as FDA, ICH and EMA and hand-on experience. Ability to work in a fast-paced growth environment, and to prioritize work from multiple projects. Demonstrates a respect for others and is open to new/different ideas. Excellent written and verbal communication skills. Preferred Qualifications Bachelors plus 15 yrs or equivalent combination of education and work experience; expert knowledge of principals and concepts and is a thought leader; has experience managing department(s) with senior employees. Organizational leader with experience managing a team of direct (and indirect) reports in technical development of CMC (analytical, process, or formulation) packages for IND/CTA submission. Demonstrated track record, broad experience, and demonstrated success in process development and operations for complex biological products.
Engineering Qualifications: Northrop Grumman Aeronautics Systems (NGAS) is looking for you to join our growing team as a Principal RF Microwave Design Engineer at our advanced facility in Beavercreek, OH. We are a unique blend of scientists, engineers, and technicians that specialize in antennas, radomes, electromagnetics structures, and RF testing primarily for aerospace applications. We design and manufacture solutions for our war fighters to keep our country safe and maintain peace on a global scale. Our electrical group is afforded the opportunity to work on state-of-the-art designs, primarily for classified applications, in both team and individual settings. Our employees are equipped with the latest hardware and software tools and advance recurring training to stay on the cutting edge. Beavercreek is one of a few facilities that allows exposure to the full life cycle of highly technical products. You'll be working side-by-side with some of the best engineering talent in the country. Our multi-faceted team consists of engineers and scientist with backgrounds in electrical / EM, CEM, RF test, mechanical, structural, thermal, CFD, material science, process, and quality - all located at our Beavercreek location. Position Summary / Responsibilities: Perform design and analysis of electromagnetic devices, primarily but not limited to antennas and radomes Develops technical solutions to a wide range of complex challenging problems; solutions are imaginative, thorough, practicable, and consistent with organization objectives Execute with general direction; can independently determine and develop solutions Contribute to the completion of specific programs and projects Engage with multidisciplinary engineering teams to collaboratively realize designs and optimize for manufacture Support technical design reviews and provide guidance to program office Support engineering build and process planning as needed to ensure product success Author test procedures and support test reports as needed Support qualification and recurring test events to ensure compliance to requirements; major responsibility to RF test, but can also include qualification and ESS test events The ideal candidate enjoys both theoretical design and hands on engineering tasks. You are inquisitive problem solver, self-sufficient, and determined with a positive attitude. Travel can vary by program and tasks but is typically very minimal. - provided by Dice
10/01/2020
Full time
Engineering Qualifications: Northrop Grumman Aeronautics Systems (NGAS) is looking for you to join our growing team as a Principal RF Microwave Design Engineer at our advanced facility in Beavercreek, OH. We are a unique blend of scientists, engineers, and technicians that specialize in antennas, radomes, electromagnetics structures, and RF testing primarily for aerospace applications. We design and manufacture solutions for our war fighters to keep our country safe and maintain peace on a global scale. Our electrical group is afforded the opportunity to work on state-of-the-art designs, primarily for classified applications, in both team and individual settings. Our employees are equipped with the latest hardware and software tools and advance recurring training to stay on the cutting edge. Beavercreek is one of a few facilities that allows exposure to the full life cycle of highly technical products. You'll be working side-by-side with some of the best engineering talent in the country. Our multi-faceted team consists of engineers and scientist with backgrounds in electrical / EM, CEM, RF test, mechanical, structural, thermal, CFD, material science, process, and quality - all located at our Beavercreek location. Position Summary / Responsibilities: Perform design and analysis of electromagnetic devices, primarily but not limited to antennas and radomes Develops technical solutions to a wide range of complex challenging problems; solutions are imaginative, thorough, practicable, and consistent with organization objectives Execute with general direction; can independently determine and develop solutions Contribute to the completion of specific programs and projects Engage with multidisciplinary engineering teams to collaboratively realize designs and optimize for manufacture Support technical design reviews and provide guidance to program office Support engineering build and process planning as needed to ensure product success Author test procedures and support test reports as needed Support qualification and recurring test events to ensure compliance to requirements; major responsibility to RF test, but can also include qualification and ESS test events The ideal candidate enjoys both theoretical design and hands on engineering tasks. You are inquisitive problem solver, self-sufficient, and determined with a positive attitude. Travel can vary by program and tasks but is typically very minimal. - provided by Dice
Engineering Qualifications: Northrop Grumman Aeronautics Systems (NGAS) is looking for you to join our growing team as a Senior Principal RF Microwave Design Engineer at our advanced facility in Beavercreek, OH. We are a unique blend of scientists, engineers, and technicians that specialize in antennas, radomes, electromagnetics structures, and RF testing primarily for aerospace applications. We design and manufacture solutions for our war fighters to keep our country safe and maintain peace on a global scale. Our electrical group is afforded the opportunity to work on state-of-the-art designs, primarily for classified applications, in both team and individual settings. Our employees are equipped with the latest hardware and software tools and advance recurring training to stay on the cutting edge. Beavercreek is one of a few facilities that allows exposure to the full life cycle of highly technical products. You'll be working side-by-side with some of the best engineering talent in the country. Our multi-faceted team consists of engineers and scientist with backgrounds in electrical / EM, CEM, RF test, mechanical, structural, thermal, CFD, material science, process, and quality - all located at our Beavercreek location. Position Summary / Responsibilities: Perform design and analysis of electromagnetic devices, primarily but not limited to antennas and radomes Represents the organization as the prime technical contact on contracts and projects; interacts with senior external personnel on significant technical matters often requiring coordination between organizations Develops technical solutions to complex problems which require the regular use of ingenuity and creativity Performs without appreciable direction; exercises considerable latitude in determining technical objectives of assignment Guides the successful completion of major programs and may function in a project leadership role; erroneous decisions or recommendations would typically result in failure to achieve major organizational objectives Engage with multidisciplinary engineering teams to collaboratively realize designs and optimize for manufacture Support technical design reviews and provide guidance to program office Support engineering build and process planning as needed to ensure product success Author test procedures and support test reports as needed Support qualification and recurring test events to ensure compliance to requirements; major responsibility to RF test, but can also include qualification and ESS test events The ideal candidate enjoys both theoretical design and hands on engineering tasks. You are an inquisitive problem solver, self-sufficient, and determined with a positive attitude. Travel can vary by program and tasks but is typically very minimal. - provided by Dice
10/01/2020
Full time
Engineering Qualifications: Northrop Grumman Aeronautics Systems (NGAS) is looking for you to join our growing team as a Senior Principal RF Microwave Design Engineer at our advanced facility in Beavercreek, OH. We are a unique blend of scientists, engineers, and technicians that specialize in antennas, radomes, electromagnetics structures, and RF testing primarily for aerospace applications. We design and manufacture solutions for our war fighters to keep our country safe and maintain peace on a global scale. Our electrical group is afforded the opportunity to work on state-of-the-art designs, primarily for classified applications, in both team and individual settings. Our employees are equipped with the latest hardware and software tools and advance recurring training to stay on the cutting edge. Beavercreek is one of a few facilities that allows exposure to the full life cycle of highly technical products. You'll be working side-by-side with some of the best engineering talent in the country. Our multi-faceted team consists of engineers and scientist with backgrounds in electrical / EM, CEM, RF test, mechanical, structural, thermal, CFD, material science, process, and quality - all located at our Beavercreek location. Position Summary / Responsibilities: Perform design and analysis of electromagnetic devices, primarily but not limited to antennas and radomes Represents the organization as the prime technical contact on contracts and projects; interacts with senior external personnel on significant technical matters often requiring coordination between organizations Develops technical solutions to complex problems which require the regular use of ingenuity and creativity Performs without appreciable direction; exercises considerable latitude in determining technical objectives of assignment Guides the successful completion of major programs and may function in a project leadership role; erroneous decisions or recommendations would typically result in failure to achieve major organizational objectives Engage with multidisciplinary engineering teams to collaboratively realize designs and optimize for manufacture Support technical design reviews and provide guidance to program office Support engineering build and process planning as needed to ensure product success Author test procedures and support test reports as needed Support qualification and recurring test events to ensure compliance to requirements; major responsibility to RF test, but can also include qualification and ESS test events The ideal candidate enjoys both theoretical design and hands on engineering tasks. You are an inquisitive problem solver, self-sufficient, and determined with a positive attitude. Travel can vary by program and tasks but is typically very minimal. - provided by Dice
